Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Alexander Kuryatov"'
Autor:
Kevin M. Braunscheidel, George Voren, Christie D. Fowler, Qun Lu, Alexander Kuryatov, Michael D. Cameron, Ines Ibañez-Tallon, Jon M. Lindstrom, Theodore M. Kamenecka, Paul J. Kenny
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
BackgroundMost smokers attempting to quit will quickly relapse to tobacco use even when treated with the most efficacious smoking cessation agents currently available. This highlights the need to develop effective new smoking cessation medications. E
Externí odkaz:
https://doaj.org/article/13755185d072421ba960bb627e47c5e1
Publikováno v:
AMB Express, Vol 10, Iss 1, Pp 1-8 (2020)
Abstract Docosahexaenoic acid (DHA) enriched in brain can yield many important degradation products after the attack of hydroxyl radicals, which is known to serve as a nutraceutical and neuroprotective effects. Oxidative stress is a commonly observed
Externí odkaz:
https://doaj.org/article/ca540d46a40740dca7b97571cccd2b8e
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229556 (2020)
The heterotrophic microalgae Crypthecodinium cohnii was usually cultivated in complex medium containing glucose, yeast extract and sea salt. For the preparation of DHA with highest purity, a new defined medium without the yeast extract was developed.
Externí odkaz:
https://doaj.org/article/b205d3f9a6cf41bc9aae167e80c41c02
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103244 (2014)
Human (α6β2)(α4β2)β3 nicotinic acetylcholine receptors (AChRs) are essential for addiction to nicotine and a target for drug development for smoking cessation. Expressing this complex AChR is difficult, but has been achieved using subunit concat
Externí odkaz:
https://doaj.org/article/68f1ffbce8c44310840bcfdb0dd3e6d6
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62246 (2013)
Functional α7 nicotinic acetylcholine receptors (AChRs) do not assemble efficiently in cells transfected with α7 subunits unless the cells are also transfected with the chaperone protein RIC-3. Despite the presence of RIC-3, large amounts of these
Externí odkaz:
https://doaj.org/article/65419f7a61f94822a910deab181d6c88
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79653 (2013)
The behavioral effects of nicotine and other nicotinic agonists are mediated by AChRs in the brain. The relative contribution of acute activation versus chronic desensitization of AChRs is unknown. Sustained "smoldering activation" occurs over a rang
Externí odkaz:
https://doaj.org/article/2122d567545c4a8ea874514cf8b4bbe1
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0229556 (2020)
PLoS ONE, Vol 15, Iss 3, p e0229556 (2020)
The heterotrophic microalgae Crypthecodinium cohnii was usually cultivated in complex medium containing glucose, yeast extract and sea salt. For the preparation of DHA with highest purity, a new defined medium without the yeast extract was developed.
Publikováno v:
Journal of Biological Chemistry. 291:23452-23463
All nicotinic acetylcholine receptors (nAChRs) evolved from homomeric nAChRs in which all five subunits are involved in forming acetylcholine (ACh) binding sites at their interfaces. Heteromeric α4β2* nAChRs typically have two ACh binding sites at
Autor:
Theodore M. Kamenecka, Angelo Blasio, Simone M. Giovanetti, Michael D. Cameron, Robert O. Messing, Matthew B. Pomrenze, Jingyi Wang, Christelle Doebelin, Jon Lindstrom, Holly L. Chapman, Victor Liaw, Alexander Kuryatov, Li Lin
Publikováno v:
Neuropsychopharmacology
There is increasing interest in developing drugs that act at α4β2 nicotinic acetylcholine receptors (nAChRs) to treat alcohol use disorder. The smoking cessation agent varenicline, a partial agonist of α4β2 nAChRs, reduces alcohol intake, but its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea2407be6ea72e8212bc31f113908ff
https://europepmc.org/articles/PMC6901472/
https://europepmc.org/articles/PMC6901472/
Autor:
Abba E. Leffler, Jingyi Wang, Theodore M. Kamenecka, Alexander Kuryatov, Jon Lindstrom, Christelle Doebelin, Jack Norleans
Publikováno v:
J Biol Chem
Nicotinic acetylcholine receptor (nAChR) ligands that lack agonist activity but enhance activation in the presence of an agonist are called positive allosteric modulators (PAMs). nAChR PAMs have therapeutic potential for the treatment of nicotine add