Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Alexander Ksendzovsky"'
Autor:
Jenna Langbein, Ujwal Boddeti, Matthew Kreinbrink, Ziam Khan, Ihika Rampalli, Muzna Bachani, Alexander Ksendzovsky
Publikováno v:
Frontiers in Network Physiology, Vol 4 (2024)
Epilepsy is one of the most common neurological disorders, affecting over 65 million people worldwide. Despite medical management with anti-seizure medications (ASMs), many patients fail to achieve seizure freedom, with over one-third of patients hav
Externí odkaz:
https://doaj.org/article/b738bf810d9444cd919286dfb255e81f
Autor:
Anirudha S. Chandrabhatla, I. Jonathan Pomeraniec, Taylor M. Horgan, Elizabeth K. Wat, Alexander Ksendzovsky
Publikováno v:
npj Digital Medicine, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Brain stimulation (BStim) encompasses multiple modalities (e.g., deep brain stimulation, responsive neurostimulation) that utilize electrodes implanted in deep brain structures to treat neurological disorders. Currently, BStim is primarily u
Externí odkaz:
https://doaj.org/article/bd472e27e728477e886b078f3a70eade
Autor:
Darrian McAfee, Mitchell Moyer, Jaden Queen, Armin Mortazavi, Ujwal Boddeti, Muzna Bachani, Kareem Zaghloul, Alexander Ksendzovsky
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Glioma-related epilepsy (GRE) is a hallmark clinical presentation of gliomas with significant impacts on patient quality of life. The current standard of care for seizure management is comprised of anti-seizure medications (ASMs) and surgical resecti
Externí odkaz:
https://doaj.org/article/651cff079cfd4dba88a71a3fd4f2e5a1
Autor:
Hari McGrath, Hitten P. Zaveri, Evan Collins, Tamara Jafar, Omar Chishti, Sami Obaid, Alexander Ksendzovsky, Kun Wu, Xenophon Papademetris, Dennis D. Spencer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Precise cortical brain localization presents an important challenge in the literature. Brain atlases provide data-guided parcellation based on functional and structural brain metrics, and each atlas has its own unique benefits for localizati
Externí odkaz:
https://doaj.org/article/ac3dd8becadc4d6d828271300d43d153
Publikováno v:
npj Digital Medicine, Vol 5, Iss 1, Pp 1-18 (2022)
Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor impairments such as tremor, bradykinesia, dyskinesia, and gait abnormalities. Current protocols assess PD symptoms during clinic visits and can be subjective.
Externí odkaz:
https://doaj.org/article/5180ff3e75934073a37fb34aa3aa186c
Autor:
Abdul-Kareem Ahmed, Sijia Guo, Nathaniel Kelm, Ryan Clanton, Elias R. Melhem, Rao P. Gullapalli, Alexander Ksendzovsky, Howard M. Eisenberg, Timothy R. Miller, Dheeraj Gandhi
Publikováno v:
Frontiers in Neurology, Vol 12 (2022)
ObjectiveMR-guided focused ultrasound (MRgFUS) is increasingly being used to treat patients with essential tremor (ET) and Parkinson's disease (PD) with thalamotomy and pallidotomy, respectively. Pallidotomy is performed off-center within the cranium
Externí odkaz:
https://doaj.org/article/70843d9fadcd4f4c995aa6bdeeab275b
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2677 (2022)
Electrocorticography (ECoG) data are commonly obtained during drug-resistant epilepsy (DRE) workup, in which subdural grids and stereotaxic depth electrodes are placed on the cortex for weeks at a time, with the goal of elucidating seizure originatio
Externí odkaz:
https://doaj.org/article/4c49f990120c46d4a37c78c0cb9d2e72
Publikováno v:
Cell Reports, Vol 3, Iss 1, Pp 52-59 (2013)
Although missense mutations of the von Hippel-Lindau disease (VHL) gene are the most common germline mutation underlying this heritable cancer syndrome, the mechanism of tumorigenesis is unknown. We found a quantitative reduction of missense mutant V
Externí odkaz:
https://doaj.org/article/3f84117a938840dd9bc25f15da79783c
Autor:
Timothy Chryssikos, Jesse A. Stokum, Abdul-Kareem Ahmed, Chixiang Chen, Aaron Wessell, Gregory Cannarsa, Nicholas Caffes, Jeffrey Oliver, Joshua Olexa, Phelan Shea, Mohamed Labib, Graeme Woodworth, Alexander Ksendzovsky, Uttam Bodanapally, Kenneth Crandall, Charles Sansur, Gary Schwartzbauer, Bizhan Aarabi
Publikováno v:
Neurosurgery. 92:353-362
Autor:
Armin Mortazavi, Islam Fayed, Muzna Bachani, Tyrone Dowdy, Jahandar Jahanipour, Anas Khan, Jemima Owotade, Stuart Walbridge, Sara K Inati, Joseph Steiner, Jing Wu, Mark Gilbert, Chun Zhang Yang, Mioara Larion, Dragan Maric, Alexander Ksendzovsky, Kareem A Zaghloul
Publikováno v:
Neuro Oncol
Background Uncontrolled seizures in patients with gliomas have a significant impact on quality of life and morbidity, yet the mechanisms through which these tumors cause seizures remain unknown. Here, we hypothesize that the active metabolite d-2-hyd