Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alexander Krok"'
Publikováno v:
Particuology. 58:153-168
Ball milling is widely used in industry to mill particulate material. The primary purpose of this process is to attain an appropriate product size with the least possible energy consumption. The process is also extensively utilised in pharmaceuticals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c28dd8a1be7eddbfd5fdc67e1e516eaf
https://doi.org/10.1016/j.partic.2021.03.008
https://doi.org/10.1016/j.partic.2021.03.008
Autor:
Charley Wu, Alexander Krok
Publikováno v:
International journal of pharmaceutics. 572
Roll compaction is a critical unit operation in the pharmaceutical manufacture. During roll compaction, a change in the internal energy of powder due to applying of external work from the rolls can generate heat and cause an increase in the temperatu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a989d18758af746d088dada5f5875648
https://pubmed.ncbi.nlm.nih.gov/31678375
https://pubmed.ncbi.nlm.nih.gov/31678375
This chapter reviews the fundamentals and applications of the most common methodologies used for modelling powder flow. Continuum and discrete approaches, such as the finite element method and the discrete element method (DEM), are described briefly.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::814a2f652f5a02562323fe971cdaf5e4
https://doi.org/10.1039/9781788016100-00147
https://doi.org/10.1039/9781788016100-00147
Publikováno v:
Chemical Engineering Research and Design. 110:141-151
In the current paper, a systematic finite element (FE) analysis of the thermo-mechanical behaviour of pharmaceutical powders during die compaction is performed using the FE solver ABAQUS. The transformation of irreversible compression work to heat du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da72c33ff30f4e5469dfd19c547210b4
https://doi.org/10.1016/j.cherd.2016.03.019
https://doi.org/10.1016/j.cherd.2016.03.019
Publikováno v:
Scientific Proceedings. Faculty of Mechanical Engineering, Vol 23, Iss 1, Pp 6-11 (2015)
The paper is focused on an analysis of the most frequently used compaction equations for powdered materials such as Heckel equation, Kawakita equation and Cooper-Eaton equation. Compacting powdered materials is accompanied by various mechanisms of de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7b1631d38532c5e077ab8c7b3f5e46
https://doaj.org/article/f662843d882842d48620b3df71d527bb
https://doaj.org/article/f662843d882842d48620b3df71d527bb
Thermal properties of powders are critical material attributes that control temperature rise during tableting and roll compaction. In this study, various analytical methods were used to measure the thermal properties of widely used pharmaceutical exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24416530b53e10439ea54d080d138da
https://surrey.eprints-hosting.org/842518/
https://surrey.eprints-hosting.org/842518/
Autor:
Charley Wu, Alexander Krok
Publikováno v:
Engineering Crystallography: From Molecule to Crystal to Functional Form ISBN: 9789402411157
Powder compaction is widely used to manufacture a wide range of particulate products. Understanding powder compaction behaviour is of practical importance to improve the efficiency of product development and the manufacturing performance. This paper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e24037ac8ade89d88933e765f7970863
https://doi.org/10.1007/978-94-024-1117-1_28
https://doi.org/10.1007/978-94-024-1117-1_28
Publikováno v:
Particuology. 16:116-131
During the production of pharmaceutical tablets using powder compaction, certain common problems can occur, such as sticking, tearing, cutting, and lamination. In the past, the compressibility of the powder was calculated only along the axis of the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9bdb8348695d622f552a0f760d85bc7
https://doi.org/10.1016/j.partic.2013.12.003
https://doi.org/10.1016/j.partic.2013.12.003
Publikováno v:
Powder Technology. 262:131-141
The aim of this article is to investigate the influence of feed stress on the velocity profile of a powder material along the vertical axis in the space between the rollers of a roll compactor. At a certain combination of frequency of rotation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1032a4a021a4a6eb9da4361c106ec5da
https://doi.org/10.1016/j.powtec.2014.04.067
https://doi.org/10.1016/j.powtec.2014.04.067
Autor:
Chuan-Yu Wu, Andreja Mirtič, Ronald John Roberts, Alexander Krok, Gavin K. Reynolds, Serena Schiano
Publikováno v:
International journal of pharmaceutics. 513(1-2)
During pharmaceutical powder compaction, temperature rise in the compressed powder can affect physiochemical properties of the powder, such as thermal degradation and change in crystallinity. Thus, it is of practical importance to understand the effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796628c2e802c47c5e38aa0f5f19c7cb
https://pubmed.ncbi.nlm.nih.gov/27601333
https://pubmed.ncbi.nlm.nih.gov/27601333