Transition‐Metal Free Electrophilic Aminations of Polyfunctional O‐2,4,6‐Trimethylbenzoyl Hydroxylamines with Zinc and Magnesium Organometallics

Autor: Alisa S. Sunagatullina, Andreas Hess, Alexander Kremsmair, Yifan Li, Yi-Hung Chen, Paul Knochel

Publikováno v: Angewandte Chemie.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6c2001dfdfc73ac741b68f85831887
https://doi.org/10.1002/ange.202304445

In Situ Quench Reactions of Enantioenriched Secondary Alkyllithium Reagents in Batch and Continuous Flow Using an I/Li-Exchange

Autor: Alexander Kremsmair, Henrik R. Wilke, Johannes H. Harenberg, Benjamin R. G. Bissinger, Matthias M. Simon, Nurtalya Alandini, Paul Knochel

Publikováno v: Angewandte Chemie (International ed. in English).

We report a practical in situ quench (ISQ) procedure involving the generation of chiral secondary alkyllithiums from secondary alkyl iodides (including functionalized iodides bearing an ester or a nitrile) in the presence of various electrophiles suc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8073e683dbb82ca03e1a068f83da4b55
https://pubmed.ncbi.nlm.nih.gov/36269064

Lithium Dichloro(2,2,6,6‐tetramethylpiperidinato)‐Magnesiate

Autor: Alexander Kremsmair, Paul Knochel, Andreas Hess

Publikováno v: Encyclopedia of Reagents for Organic Synthesis. :1-5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2810433138a78ad1d2d89db9f0cf733a
https://doi.org/10.1002/047084289x.rn02373

Exploiting Coordination Effects for the Regioselective Zincation of Diazines Using TMPZnX⋅LiX (X=Cl, Br)

Autor: Alexander Kremsmair, Alisa S. Sunagatullina, Leonie J. Bole, Pasquale Mastropierro, Simon Graßl, Henrik R. Wilke, Edouard Godineau, Eva Hevia, Paul Knochel

Publikováno v: Kremsmair, Alexander; Sunagatullina, Alisa S.; Bole, Leonie J; Mastropierro, Pasquale; Graßl, Simon; Wilke, Henrik R.; Godineau, Edouard; Hevia, Eva; Knochel, Paul (2022). Exploiting Coordination Effects for the Regioselective Zincation of Diazines Using TMPZnX⋅LiX (X=Cl, Br). Angewandte Chemie International Edition, 61(40), e202210491. GDCh 10.1002/anie.202210491

A new method for regioselective zincations of challenging N-heterocyclic substrates such as pyrimidines and pyridazine was reported using bimetallic bases TMPZnX⋅LiX (TMP=2,2,6,6-tetramethylpiperidyl; X=Cl, Br). Reactions occurred under mild condit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07aa595137d1137781e7dbea5860be74
https://pubmed.ncbi.nlm.nih.gov/35943036

Regio- and diastereoselective reactions of chiral secondary alkylcopper reagents with propargylic phosphates: preparation of chiral allenes†

Autor: Juri Skotnitzki, Franziska Schüppel, Alexander Kremsmair, Paul Knochel, Daniel Keefer, Regina de Vivie-Riedle, Brieuc Le Cacher de Bonneville

Publikováno v: Chemical Science

The diastereoselective SN2′-substitution of secondary alkylcopper reagents with propargylic phosphates enables the preparation of stereodefined alkylallenes. By using enantiomerically enriched alkylcopper reagents and enantioenriched propargylic ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1b6433311c488765ff2b624e71705f
http://europepmc.org/articles/PMC8159386