Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Alexander Kröber"'
Autor:
Stephan Stilgenbauer, Sandrine Sander, Lars Bullinger, Axel Benner, Elke Leupolt, Dirk Winkler, Alexander Kröber, Dirk Kienle, Peter Lichter, Hartmut Döhner
Publikováno v:
Haematologica, Vol 92, Iss 9 (2007)
In chronic lymphocytic leukemia (CLL), the acquisition of new genomic aberrations during the disease course (clonal evolution) is thought to be an infrequent phenomenon but comprehensive analyses are limited. Genomic aberrations were analyzed by fluo
Externí odkaz:
https://doaj.org/article/928d36c29b1a4ad782bcdfeaf0cf9b40
Autor:
Michael Schmitt, Jochen Greiner, T F E Barth, Krzysztof Giannopoulos, Alexander Kröber, Stephan Stilgenbauer, Daniel Mertens, Hartmut Döhner, Anna Dmoszynska, Andreas Bühler, Sylwia Chocholska, Irina Idler, Jacek Roliński, Peter Möller
Publikováno v:
Leukemia. 23:519-527
Differential expression of molecules in chronic lymphocytic leukemia (CLL) may define prognostic markers and suitable targets for immunotherapy. Expression of the tumor-associated antigen (TAA) RHAMM (receptor for hyaluronic acid-mediated motility) a
Autor:
Stephan Stilgenbauer, Hartmut Döhner, Katrin Scherer, Alexander Kröber, Sonja Häbe, Dirk Winkler, Axel Benner, Andreas Bühler, Thorsten Zenz, Tina Denzel, Jennifer Edelmann, Carsten Schwänen
Publikováno v:
Blood. 112:3322-3329
The exact prognostic role of TP53 mutations (without 17p deletion) and any impact of the deletion without TP53 mutation in CLL are unclear. We studied 126 well-characterized CLL patients by direct sequencing and DHPLC to detect TP53 mutations (exons
Autor:
Peter Lichter, Stephan Stilgenbauer, Axel Benner, Hartmut Döhner, Dirk Kienle, Alexander Kröber, Elke Leupolt, Dirk Winkler, Sandrine Sander, Lars Bullinger
Publikováno v:
Haematologica. 92:1242-1245
In chronic lymphocytic leukemia (CLL), the acquisition of new genomic aberrations during the disease course (clonal evolution) is thought to be an infrequent phenomenon but comprehensive analyses are limited. Genomic aberrations were analyzed by fluo
Autor:
Oswald Wagner, Martin Bilban, T Scharl, Birgit Kainz, Alexander Kröber, Christoph C. Zielinski, A. Gaiger, Stephan Stilgenbauer, Medhat Shehata, E. Porpaczy, Michael Auer, T Woelfel, Daniel Heintel, Ulrich Jäger, Vincent J. Carey, Winfried F. Pickl
Publikováno v:
Leukemia. 20:1080-1088
Lipoprotein lipase (LPL) is a prognostic marker in B-cell chronic lymphocytic leukemia (B-CLL) related to immunoglobulin V(H) gene (IgV(H))mutational status. We determined gene expression profiles using Affymetrix U133A GeneChips in two groups of B-C
Autor:
Johannes Bloehdorn, Markus Bangerter, Stephan Stilgenbauer, Andreas Bühler, Dirk Winkler, Richard F. Schlenk, Sebastian Hafner, Dirk Kienle, Till Seiler, Hartmut Döhner, Peter Lichter, Axel Benner, Alexander Kröber
Publikováno v:
Journal of Clinical Oncology. 24:969-975
Purpose Immunoglobulin heavy chain variable-region (VH) gene mutation status and zeta-associated protein 70 (ZAP-70) expression are correlated in chronic lymphocytic leukemia (CLL), but their concordance is variable. The goal of this study was to elu
Autor:
Gerard Tobin, Mats Merup, Juhani Vilpo, Karin Karlsson, Göran Roos, Hartmut Döhner, Dirk Kienle, Christer Sundström, Helena Jernberg-Wiklund, Ulf Thunberg, Anna Åleskog, Richard Rosenquist, Anna Laurell, Alexander Kröber, Karin Nilsson, Stephan Stilgenbauer, A Skogsberg
Publikováno v:
Leukemia. 20:77-81
The G(-248)A polymorphism in the promoter region of the Bax gene was recently associated with low Bax expression, more advanced stage, treatment resistance and short overall survival in B-cell chronic lymphocytic leukemia (CLL), the latter particular
Autor:
Andreas Chott, Dieter Mitteregger, Christine Mannhalter, Alexander Gaiger, Elisabeth Kroemer, Stephan Stilgenbauer, Hartmut Döhner, Dirk Kienle, Josef D. Schwarzmeier, A Gleiß, Alexander Kröber, Medhat Shehata, Ulrich Jäger, Ilse Schwarzinger, Trang Le, Daniel Heintel, Christa Fonatsch
Publikováno v:
Leukemia. 19:1216-1223
We investigated the pattern of lipoprotein lipase (LPL) expression in B-cell chronic lymphocytic leukemia (B-CLL) and assessed its prognostic relevance. Expression of LPL mRNA as well as protein was highly restricted to leukemic B cells. The intensit
Autor:
Peter Liebisch, Alexander Kröber, Hartmut Döhner, Sonja Kolmus, Alexander Wellmann, Christiane Wendl, Sibylle Janczik, Seiichi Alvise Erné, Hartmut Goldschmidt, Christian Straka, Axel Benner, Daniel Scheck, Stephan Stilgenbauer, Hermann Einsele
Publikováno v:
Genes, Chromosomes and Cancer. 42:78-81
14q32 translocations [t(14q)] represent critical but not universal events in multiple myeloma (MM). Gains of chromosome arms 1q, 9q, and 11q (+1q, +9q, and +11q) have recently been identified as frequent aberrations in this disease, but their pathoge
Autor:
Norbert Schmitz, Matthias Ritgen, Hartmut Döhner, Axel Benner, Stephan Stilgenbauer, Michael Kneba, Alexander Kröber, Peter Dreger
Publikováno v:
Blood. 103:2850-2858
To assess the therapeutic value of sequential high-dose therapy (SHDT) including autologous stem cell transplantation in chronic lymphocytic leukemia (CLL) we performed a risk-matched comparison between 66 patients who had undergone a uniform SHDT re