Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alexander Klimka"'
Autor:
Alexander Klimka, Sonja Mertins, Anne Kristin Nicolai, Liza Marie Rummler, Paul G. Higgins, Saskia Diana Günther, Bettina Tosetti, Oleg Krut, Martin Krönke
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-12 (2021)
Abstract Staphylococcus aureus represents a serious infectious threat to global public health and a vaccine against S. aureus represents an unmet medical need. We here characterise two S. aureus vaccine candidates, coproporphyrinogen III oxidase (Cgo
Externí odkaz:
https://doaj.org/article/e431207387584fa2afd867fea5da2aca
Autor:
Sonja Mertins, Paul G. Higgins, Caroline Thunissen, Henri Magein, Quentin Gilleman, Pascal Mertens, María González Rodríguez, Liza Marie Maus, Harald Seifert, Martin Krönke, Alexander Klimka
Publikováno v:
Journal of Medical Microbiology. 72
Introduction. Acinetobacter baumannii infections can be extremely challenging to treat owing to the worldwide prevalence of multidrug-resistant isolates, especially against carbapenems. Colonization with carbapenem-resistant A. baumannii (CRAb) requi
Autor:
Alexander Klimka, Paul G. Higgins, María González Rodríguez, Pascal Mertens, Céline Borlon, Harald Seifert, Quentin Gilleman, Sonja Mertins, Martin Krönke
Publikováno v:
Journal of Medical Microbiology. 68:1021-1032
Introduction. The spread of carbapenem-resistant Acinetobacter baumannii has led to a worldwide healthcare problem. Carbapenem resistance in A. baumannii is mainly mediated by the acquisition of the carbapenem-hydrolyzing oxacillinase OXA-23. The phe
Autor:
Mohsen Navari, Majid Asadi-Ghalehni, Alexander Klimka, Masoud Javanmardi, Mohamad Ghaemmaghami, Mohammad Javad Rasaee
Publikováno v:
Immunopharmacology and Immunotoxicology. 37:274-279
To date, several small molecule inhibitors and monoclonal-antibodies (like ICR-62) have been used to treat tumors over-expressing epidermal growth factor receptor (EGFR). However, the limitations associated with these conventional applications accent
Autor:
Hinrich P. Hansen, Roland Schnell, Peter Borchmann, Michael Huhn, Baerbel Matthey, Alexander Klimka, Stefan Barth, Hans Lange, Samir Tawadros, Andreas Engert, Mehmet Kemal Tur
Publikováno v:
International Journal of Cancer. 111:568-574
There is increasing evidence that the shedding of extracellular antigen domains impedes selective immunotherapy. One example is CD30, which is overexpressed on the surface of malignant lymphoma cells and has been identified as a promising target for
Publikováno v:
Cytokine. 22:134-141
Interleukin-2 (IL-2) is a 15 kDa cytokine secreted by T-cells. Consequence to its natural function as locally secreted short-term messenger, its half-life in circulation is short and provided mainly by fast renal clearance due to its low molecular we
Publikováno v:
Gene. 229:145-153
Recombinant immunotoxins (rITs) are highly specific anti-tumor agents composed of monoclonal antibody fragments or other specific carriers coupled to plant or bacterial toxins. A major problem in the purification of rITs is the low periplasmic yield
Publikováno v:
BMC Molecular Biology, Vol 9, Iss 1, p 37 (2008)
BMC Molecular Biology
BMC Molecular Biology
Background The display of binding ligands, such as recombinant antibody fragments, on the surface of filamentous phage makes it possible to specifically attach these phage particles to target cells. After uptake of the phage, their internal single-st
Autor:
Andreas Engert, Michael Stöcker, Rainerr Fischer, Mehmet Kemal Tur, Stefan Barth, Ute Goerres, Alexander Klimka, Michael Huhn, Achim Rothe, Ricarda Finner
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
Isolation of cell-surface specific antibodies prerequisites the functional expressing of antigens on intact cells, which are maintained routinely by cell culturing. However, long-term culturing of tumor cells could alter their antigen expression patt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1459e65de683c6e35275f52e829f4d9b
https://publica.fraunhofer.de/handle/publica/204297
https://publica.fraunhofer.de/handle/publica/204297