Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Alexander Kister"'
Autor:
Nathalie Paul, Venetia Karamitsou, Clemens Giegerich, Afshin Sadeghi, Moritz Lücke, Britta Wagenhuber, Alexander Kister, Markus Rehberg
Publikováno v:
Frontiers in Systems Biology, Vol 4 (2024)
In the context of in silico clinical trials, mechanistic computer models for pathophysiology and pharmacology (here Quantitative Systems Pharmacology models, QSP) can greatly support the decision making for drug candidates and elucidate the (potentia
Externí odkaz:
https://doaj.org/article/60fdcd65671c491d81e430f1da7b0bf0
Autor:
Alexander Kister, Ilya Kister
Publikováno v:
Frontiers in Chemistry, Vol 10 (2023)
Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains the main characteristics of biological membranes, such as lipid bilayer, but differs from them in several important respects. In this review, we focus on as
Externí odkaz:
https://doaj.org/article/479a434113514d57831f375e5acf3f81
Autor:
Alexander Kister
Publikováno v:
Biomolecules, Vol 5, Iss 1, Pp 41-59 (2015)
We present an alternative approach to protein 3D folding prediction based on determination of rules that specify distribution of “favorable” residues, that are mainly responsible for a given fold formation, and “unfavorable” residues, that ar
Externí odkaz:
https://doaj.org/article/a85666c7e9834aa59f1670bf08fa17c6
Autor:
Dorina Weichert, Alexander Kister, Sebastian Houben, Peter Volbach, Marcus Trost, Johannes Hartung, Alexander Bergner, Stefan Wrobel
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efb24b6f5b18863181e45617f6cc7d4d
https://doi.org/10.2139/ssrn.4180760
https://doi.org/10.2139/ssrn.4180760
Publikováno v:
ICDM
The goal of active class selection (ACS) is to optimize the class proportions in newly acquired data; a classifier trained from that data should exhibit maximum performance during its deployment. This paper provides an information-theoretic examinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78838f9c510e50216afb2a83a5bf8934
https://doi.org/10.1109/icdm50108.2020.00106
https://doi.org/10.1109/icdm50108.2020.00106
Autor:
Alexander Kister
This study addresses the following fundamental question: Do sequences of protein domains with sandwich architecture have common sequence characteristics even though they belong to different superfamilies and folds? The analysis was carried out in two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51ce1ff0db7f3200c7673aa86c246b15
https://doi.org/10.1101/2020.05.27.108969
https://doi.org/10.1101/2020.05.27.108969
Autor:
Alexander Kister
Publikováno v:
Methods in Molecular Biology ISBN: 9781493991600
The goal is to define sequence characteristics of beta-sandwich proteins that are unique for the beta-sandwich supersecondary structure (SSS). Finding of the conserved residues that are critical for protein structure can often be accomplished with ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::829ab583fb1d7d61bb97efbd48eb4961
https://doi.org/10.1007/978-1-4939-9161-7_16
https://doi.org/10.1007/978-1-4939-9161-7_16
Autor:
Israel M. Gelfand, Alexander Kister
Publikováno v:
Proceedings of the National Academy of Sciences. 106:18996-19000
This work evaluates the hypothesis that proteins with an identical supersecondary structure (SSS) share a unique set of residues—SSS-determining residues—even though they may belong to different protein families and have very low sequence similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d2ddf57079066c2c4c5dddb81030e6
https://doi.org/10.1073/pnas.0909714106
https://doi.org/10.1073/pnas.0909714106
Publikováno v:
Journal of Molecular Biology. 342:665-679
Structural analysis of a non-redundant data set of 47 immunoglobulin (Ig) proteins was carried out using a combination of criteria: atom--atom contact compatibility, position occupancy rate, conservation of residue type and positional conservation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331eb68fe0c5eef02752aec1f43aa52d
https://doi.org/10.1016/j.jmb.2004.06.072
https://doi.org/10.1016/j.jmb.2004.06.072
Publikováno v:
Proceedings of the National Academy of Sciences. 99:14137-14141
The goal of this work is to define the structural and sequence features common to sandwich-like proteins (SPs), a group of very different proteins now comprising 69 superfamilies in 38 protein folds. Analysis of the arrangements of strands within mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65c3c0b826e78cb62a3798bb78bdcd1
https://doi.org/10.1073/pnas.212511499
https://doi.org/10.1073/pnas.212511499