Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Alexander Karpeisky"'
Publikováno v:
Bone Reports, Vol 9, Iss , Pp 47-60 (2018)
Bones provide essential functions and are sites of unique biochemistry and specialized cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has presented difficulties in the past, and improved delivery of drugs to bo
Externí odkaz:
https://doaj.org/article/22c276b4b5674c1284daf05148ff0c7b
Publikováno v:
Bioconjug Chem
Patients with cancer-induced bone disease, including primary bone cancers such as osteosarcoma (OS) and metastases from other tissues of origin, present a high unmet medical need. We present a potential therapeutic approach built upon a proven bone-t
Publikováno v:
Bone Reports
Bone Reports, Vol 9, Iss, Pp 47-60 (2018)
Bone Reports, Vol 9, Iss, Pp 47-60 (2018)
Bones provide essential functions and are sites of unique biochemistry and specialized cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has presented difficulties in the past, and improved delivery of drugs to bo
Publikováno v:
The Oncologist
Lessons Learned Results are consistent with MBC-11 targeting and treating cancer-induced bone lesions by concentrating cytarabine and etidronate at the site of disease. MBC-11 was well tolerated, with an maximum tolerated dose of 5 mg/kg per day and
Autor:
Harri Lönnberg, Luis Sanchez-Perez, Vivian Negron, David P Sebesta, Shawn Zinnen, Monica M. Reinholz, Diane F. Jelinek, Anthony J. Croatt, Amylou C. Dueck, Leslie M. Jonart, Henry B F Hal Dixon, James N. Ingle, Wilma L. Lingle, Thomas C. Spelsberg, Toshiyuki Yoneda, Gregory G. Reinholz, David Dingli, Kathleen A Kitzmann, Karl A. Nath, Abdalla K Abdalla, Bonnie K. Arendt, Stephen J. Russell, Alexander Karpeisky, Amy K Bruzek
Publikováno v:
Bone. 47:12-22
Despite palliative treatments, tumor-induced bone disease (TIBD) remains highly debilitating for many cancer patients and progression typically results in death within two years. Therefore, more effective therapies with enhanced anti-resorptive and c
Autor:
Shawn Zinnen, Larisa Plekhova, Alexander Karpeisky, Marina Roudas, Alexander Alexandrov, Eric K. Rowinsky
Publikováno v:
Journal of Clinical Oncology. 35:2589-2589
2589 Background: MBC-11 is a first-in-class therapeutic conjugate of the bone targeting bisphosphonate etidronate covalently linked to the antimetabolite cytosine arabinoside (Ara-C). In preclinical studies, MBC-11 localizes at the site of cancer-ind
Functionalized nucleoside 5′-triphosphates for in vitro selection of new catalytic ribonucleic acids
Autor:
Andrew T. Daniher, David Sweedler, Alexander Karpeisky, Peter Haeberli, Jasenka Matulic-Adamic, Leonid Beigelman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1299-1302
A series of novel 2'-modified nucleoside 5'-triphosphates was synthesized. The amino, imidazole, and carboxylate functionalities were attached to the 5-position of pyrimidine base of these molecules through alkynyl and alkyl spacers, respectively. Tw
Publikováno v:
Tetrahedron. 56:1047-1056
We developed several improved approaches toward 2′- O -methyl adenosine and guanosine and their N -acyl derivatives. (a) Transglycosylation of N 4 -acetyl-5′, 3′-di- O -acetyl-2′- O -methyl cytidine with N 6 -Bz-adenine provided N 6 -benzoyl-
Highly efficient synthesis of 2′-O-amino nucleosides and their incorporation in hammerhead ribozymes
Publikováno v:
Tetrahedron Letters. 39:1131-1134
2′- O -Amino nucleosides were prepared from arabino nucleosides by triflate displacement with N-hydroxy phthalimide. The corresponding phosphoramidites suitable for automated oligonucleotide synthesis, were also prepared. Incorporation of 2′- O -
Autor:
Leonid Beigelman, Alexander Karpeisky, Nassim Usman, William G. Scott, Daniel P Terwey, James B. Murray, Lara Maloney
Publikováno v:
Murray, JB; Terwey, DP; Maloney, L; Karpeisky, A; Usman, N; Beigelman, L; et al.(2015). The structural basis of hammerhead ribozyme self-cleavage.. Cell, 92, 665-73. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/4mw283sf
We have captured an 8.7 A conformational change that takes place in the cleavage site of the hammerhead ribozyme during self-cleavage, using X-ray crystallography combined with physical and chemical trapping techniques. This rearrangement brings the