Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alexander KNA"'
Autor:
Khush Patel, Ziqian Xie, Hao Yuan, Sheikh Muhammad Saiful Islam, Yaochen Xie, Wei He, Wanheng Zhang, Assaf Gottlieb, Han Chen, Luca Giancardo, Alexander Knaack, Evan Fletcher, Myriam Fornage, Shuiwang Ji, Degui Zhi
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Understanding the genetic architecture of brain structure is challenging, partly due to difficulties in designing robust, non-biased descriptors of brain morphology. Until recently, brain measures for genome-wide association studies (GWAS) c
Externí odkaz:
https://doaj.org/article/b0f58036a25e4ec1841c900ee0bc6460
Autor:
Steffen Lippold, Karishma Mistry, Sunidhi Lenka, Kevin Whang, Peilu Liu, Sebastian Pitschi, Felix Kuhne, Dietmar Reusch, Lance Cadang, Alexander Knaupp, Saeed Izadi, Alexis Dunkle, Feng Yang, Tilman Schlothauer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Human Fc gamma receptor IIa (FcγRIIa) or CD32a has two major allotypes with a single amino acid difference at position 131 (histidine or arginine). Differences in FcγRIIa allotypes are known to impact immunological responses such as the clinical ou
Externí odkaz:
https://doaj.org/article/69a3b2655a744a0981d1ba12450c4881
Autor:
Bastiaan Laurens Duivelshof, Thomas Bouvarel, Sebastian Pirner, Vincent Larraillet, Alexander Knaupp, Hans Koll, Valentina D’Atri, Davy Guillarme
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16623 (2023)
Charge heterogeneity among therapeutic monoclonal antibodies (mAbs) is considered an important critical quality attribute and requires careful characterization to ensure safe and efficacious drug products. The charge heterogeneity among mAbs is the r
Externí odkaz:
https://doaj.org/article/058ad9f8adda431883f800c97660832e
Autor:
Christoph Gstöttner, Alexander Knaupp, Gestur Vidarsson, Dietmar Reusch, Tilman Schlothauer, Manfred Wuhrer, Elena Domínguez-Vega
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The impact of antibody glycoforms on FcγRIIa activation and immune responses is poorly understood. Yet, glycoform binding assessment remains one of the major analytical challenges requiring long enrichment or glycoengineering steps. Here, we develop
Externí odkaz:
https://doaj.org/article/9fdd4b98cb2049af8d3785c42cceb466
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Deep learning implementations using convolutional neural nets have recently demonstrated promise in many areas of medical imaging. In this article we lay out the methods by which we have achieved consistently high quality, high throughput computation
Externí odkaz:
https://doaj.org/article/e04ecadb414949a3ab7eaafa492bc166
Autor:
Steffen Lippold, Alexander Knaupp, Arnoud H. de Ru, Rayman T. N. Tjokrodirijo, Peter A. van Veelen, Erwin van Puijenbroek, Steven W. de Taeye, Dietmar Reusch, Gestur Vidarsson, Manfred Wuhrer, Tilman Schlothauer, David Falck
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
The crystallizable fragment (Fc) of immunoglobulin G (IgG) activates key immunological responses by interacting with Fc gamma receptors (FcɣR). FcɣRIIIb contributes to neutrophil activation and is involved in antibody-dependent cellular cytotoxicit
Externí odkaz:
https://doaj.org/article/304e5e39a8ea4ca9a3464086e8534f7a
Autor:
Thomas E. Kraft, Wolfgang F. Richter, Thomas Emrich, Alexander Knaupp, Michaela Schuster, Andreas Wolfert, Hubert Kettenberger
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The pharmacokinetic (PK) properties of therapeutic antibodies directly affect efficacy, dose and dose intervals, application route and tissue penetration. In indications where health-care providers and patients can choose between several efficacious
Externí odkaz:
https://doaj.org/article/fa4ed80fa74740e48dfa85c307a36245
Autor:
Alexander Knapp, Lakiesha N. Williams
Publikováno v:
Bioengineering, Vol 9, Iss 2, p 54 (2022)
The anterior cruciate ligament (ACL) plays a pivotal role in support of the knee under loading. When damaged, it is known that substantial changes in the mechanics of the neighboring ligaments can be observed. However, a localized damage approach to
Externí odkaz:
https://doaj.org/article/b9a96953a40946379e7b07d398d8b07e
Autor:
Tetyana Dashivets, Marco Thomann, Petra Rueger, Alexander Knaupp, Johannes Buchner, Tilman Schlothauer
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143520 (2015)
Therapeutic performance of recombinant antibodies relies on two independent mechanisms: antigen recognition and Fc-mediated antibody effector functions. Interaction of Fc-fragment with different FcR triggers antibody-dependent cellular cytotoxicity a
Externí odkaz:
https://doaj.org/article/3fed091754384dec8a0d04e6fc49c565
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