Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alexander K. Winkel"'
Autor:
Céline Labouesse, Bao Xiu Tan, Chibeza C. Agley, Moritz Hofer, Alexander K. Winkel, Giuliano G. Stirparo, Hannah T. Stuart, Christophe M. Verstreken, Carla Mulas, William Mansfield, Paul Bertone, Kristian Franze, José C. R. Silva, Kevin J. Chalut
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The independent control of substrate stiffness and tethering of extracellular matrix to substrates for mechanical signalling investigations remains challenging. Here the authors present StemBond hydrogels, with stable ECM tethering that can be varied
Externí odkaz:
https://doaj.org/article/2711320dd2f24be2b2c8cdd0355b3ae1
Autor:
Edward Jenkins, Simon J. Davis, David Klenerman, Jane Humphrey, Ana Filipa L.O.M. Santos, Ivan B Dimov, James McColl, Alexander K. Winkel, Anna Lippert, Kevin Y. Chen, Kristian Franze
Publikováno v:
Biophysical Journal
Much of what we know about the early stages of T cell activation has been obtained from studies of T cells interacting with glass-supported lipid bilayers that favor imaging but are orders of magnitude stiffer than typical cells. We developed a metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2148fffd6edf079b8d86778c2acc657f
https://doi.org/10.1016/j.bpj.2020.11.021
https://doi.org/10.1016/j.bpj.2020.11.021
Autor:
Bao Xiu Tan, Céline Labouesse, Carla Mulas, Alexander K. Winkel, Moritz Hofer, Christophe M. Verstreken, Chibeza C. Agley, Kevin J. Chalut, José C. R. Silva, Giuliano Giuseppe Stirparo, Paul Bertone, Kristian Franze, William Mansfield, Hannah T. Stuart
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Funder: Medical Research Council (UK) Career Development Award (G1100312/1)
Funder: Medical Research Council (UK) MR/M011089/1 Wellcome Trust-Medical Research Council core funding to the Wellcome-MRC Cambridge Stem Cell Institute
Studies of
Funder: Medical Research Council (UK) MR/M011089/1 Wellcome Trust-Medical Research Council core funding to the Wellcome-MRC Cambridge Stem Cell Institute
Studies of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79db56a2eb87774cd06d0a784eb5336e
https://www.repository.cam.ac.uk/handle/1810/329719
https://www.repository.cam.ac.uk/handle/1810/329719
Autor:
Edward Jenkins, Ivan B Dimov, Kevin Y. Chen, Simon J. Davis, David Klenerman, Alexander K. Winkel, Anna Lippert, Jane Humphrey, Ana Filipa L.O.M. Santos, James McColl, Kristian Franze
The T-cell receptor (TCR) is thought to be triggered either by mechano-transduction or local tyrosine phosphatase exclusion at cell-cell contacts. However, the effects of the mechanical properties of activating surfaces have only been tested for late
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0d00e8a03e37e6cfa4223c44f47a614
https://doi.org/10.1101/2020.06.05.134684
https://doi.org/10.1101/2020.06.05.134684
Autor:
Alexander K. Winkel, Simon J. Davis, David Klenerman, Steven F. Lee, Edward Jenkins, Aleks Ponjavic, Anna Lippert, Klara Kulenkampff, Jane Humphrey, Ana Filipa L.O.M. Santos, Kristian Franze, James McColl
Publikováno v:
BASE-Bielefeld Academic Search Engine
Biophysical Journal
Biophysical Journal
Cell-cell contacts often underpin signaling between cells. For immunology, the binding of a T cell receptor to an antigen-presenting pMHC initiates downstream signaling and an immune response. Although this contact is mediated by proteins on both cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3cd88fe46690c89a7df2d877643cdc
Autor:
Thomas Henze, Jörg Barner, Florian Kumpfe, Tanja Neumann, Alexander K Winkel, Heiko Haschke, André Körnig
Publikováno v:
Microscopy Today. 24:12-17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9f75664c91c30c5e0d4fffab085fd42
https://doi.org/10.1017/s1551929516000900
https://doi.org/10.1017/s1551929516000900