Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alexander K. Mullen"'
Autor:
Jean-Marc Henry, David Milne, Dave Perkins, William Hicks, David R. J. Hose, Andrew D. Campbell, Alexander K. Mullen, Phillip A. Inglesby, Steven A. Raw, Martin F. Jones
Publikováno v:
Organic Process Research & Development. 27:488-495
Publikováno v:
Organic Process Research & Development. 26:1029-1037
Autor:
Dobson Benjamin Charles, Chris Wimsey, Lai C. Chan, Steven A. Raw, Anna Jawor-Baczynska, David R. J. Hose, Martin F. Jones, David Perkins, Alex L. Lamacraft, Angus E. McMillan, Matthew Burns, Alan Steven, Alexander K. Mullen, Phillip A. Inglesby, Ahmed Elmekawy, Michael John Pilling
Publikováno v:
Organic Process Research & Development. 25:858-870
Route design and process development of the small nitrogen heterocycle 2·HCl, a constituent of AZD5718 (1), is described. The novel synthetic sequence to 2.HCl involves a desymmetrizing alkylation ...
Autor:
Angus E. McMillan, Holly L. Carter, James F. McCabe, Alan Steven, Allyson C. McIntyre, Natalie R. Monks, Amand W. Connor, Richard Hart, Alexander K. Mullen, Thomas O. Ronson, Simone Tomasi, Simon D. Yates
Publikováno v:
Reaction Chemistry & Engineering. 4:1658-1673
A wide variety of technology platforms were used to rapidly select a commercial manufacturing route to the inhaled glucocorticoid receptor modulator AZD7594. This collaborative approach to the route design employed idea generation, high-throughput sa
Autor:
Lai Chun Chan, Ian W. Ashworth, Michael John Pilling, Alexander K. Mullen, Angus McMillan, Maria Rita Galan Espinosa, Steven A. Raw, Alan Steven, Martin F. Jones
Publikováno v:
The Journal of Organic Chemistry. 84:4629-4638
A selective aziridinium ring-opening was used to etherify an α-aryl-β-amino alcohol with stereochemical retention. This transformation was achieved in a biphasic system to address phenoxide solubility and the formation of a sulfonate ester impurity
From libraries to candidate: The discovery of new ultra long-acting dibasic β2-adrenoceptor agonists
Autor:
Stephen Connolly, Stephen Jordan, Stuart W. Paine, Phillip Thorne, Nicholas Kindon, Andrew Bailey, Alexander K. Mullen, I.A. Dainty, Mandy Lawson, David J. Nicholls, Garry Pairaudeau, Robert Jewell, Lilian Alcaraz, Michael J. Stocks, Alan Young, Elaine Cadogan, Andrew Lister
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:689-695
Libraries of dibasic compounds designed around the molecular scaffold of the DA2/β2 dual agonist sibenadet (Viozan™) have yielded a number of promising starting points that have been further optimised into novel potent and selective target molecul