Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Alexander K. Lyashchenko"'
Autor:
S. Ali Husain, MD, Jacob S. Stevens, MD, Kristen L. King, MPH, Shelief Y. Robbins-Juarez, MD, Matthew Cohen, MD, Alexander K. Lyashchenko, MD, Serge Cremers, PhD, PharmD, Sumit Mohan, MD
Publikováno v:
Kidney Medicine, Vol 5, Iss 1, Pp 100572- (2023)
Externí odkaz:
https://doaj.org/article/dfe85625590d4702925ee660e66e8d30
ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function
Autor:
Aarti Sharma, Alexander K. Lyashchenko, Lei Lu, Sara Ebrahimi Nasrabady, Margot Elmaleh, Monica Mendelsohn, Adriana Nemes, Juan Carlos Tapia, George Z. Mentis, Neil A. Shneider
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The mechanism by which FUS mutations cause familial ALS remains unclear. Here, the authors use mouse transgenic models to show that a toxic gain-of-function underlies motor neuron degeneration, and that the toxicity of mutant FUS does not depend on a
Externí odkaz:
https://doaj.org/article/320664c72a834d799df983f0633c7d56
Autor:
Vladislav A. Korobeynikov, Alexander K. Lyashchenko, Beatriz Blanco-Redondo, Paymaan Jafar-Nejad, Neil A. Shneider
Publikováno v:
Nature Medicine
Fused in sarcoma (FUS) is an RNA-binding protein that is genetically and pathologically associated with rare and aggressive forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). To explore the mechanisms by which mutant FUS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced4169d34309a6f78c2883b2e447078
http://europepmc.org/articles/PMC8799464
http://europepmc.org/articles/PMC8799464