Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Alexander K. Andrianov"'
Publikováno v:
Communications Materials, Vol 5, Iss 1, Pp 1-9 (2024)
Abstract Polyorganophosphazenes are water-soluble macromolecules with immunoadjuvant activity that self-assemble with proteins to enable biological functionality. Direct imaging by cryogenic electron microscopy uncovers the coil structure of those hi
Externí odkaz:
https://doaj.org/article/ae6f14e5ec0242a5a0e0dcb827edfc78
Autor:
Michael Lueckheide, Alexander Marin, Harichandra D. Tagad, Nicholas D. Posey, Vivek M. Prabhu, Alexander K. Andrianov
Publikováno v:
ACS Polymers Au, Vol 3, Iss 5, Pp 354-364 (2023)
Externí odkaz:
https://doaj.org/article/fcf830e7e8d74e9db4c6f48aa6e91a38
Autor:
Jordan Brito, Junho Moon, Raman Hlushko, Aliaksei Aliakseyeu, Alexander K. Andrianov, Svetlana A. Sukhishvili
Publikováno v:
Journal of Functional Biomaterials, Vol 15, Iss 2, p 26 (2024)
Degradable layer-by-layer (LbL) polymeric coatings have distinct advantages over traditional biomedical coatings due to their precision of assembly, versatile inclusion of bioactive molecules, and conformality to the complex architectures of implanta
Externí odkaz:
https://doaj.org/article/8fcc6bd506da4c7e80869d1c729d45e5
Autor:
Sarah M. Valencia, Athina Zacharia, Alexander Marin, Rebecca L. Matthews, Chia-Kuei Wu, Breana Myers, Chelsea Sanders, Simone Difilippantonio, Reinhard Kirnbauer, Richard B. Roden, Ligia A. Pinto, Robert H. Shoemaker, Alexander K. Andrianov, Jason D. Marshall
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 17, Iss 8, Pp 2748-2761 (2021)
Current human papillomavirus (HPV) vaccines provide substantial protection against the most common HPV types responsible for oral and anogenital cancers, but many circulating cancer-causing types remain for which vaccine coverage is lacking. In addit
Externí odkaz:
https://doaj.org/article/da65fc9e002b4c96bf1c802105da3c14
Autor:
Harichandra D. Tagad, Alexander Marin, Ruixue Wang, Abdul S. Yunus, Thomas R. Fuerst, Alexander K. Andrianov
Publikováno v:
Molecules, Vol 28, Iss 10, p 4218 (2023)
The inclusion of fluorine motifs in drugs and drug delivery systems is an established tool for modulating their biological potency. Fluorination can improve drug specificity or boost the vehicle’s ability to cross cellular membranes. However, the a
Externí odkaz:
https://doaj.org/article/c1bba17057a84218a9ce32a36ced909b
Autor:
Andrey Romanyuk, Ruixue Wang, Alexander Marin, Benjamin M. Janus, Eric I. Felner, Dengning Xia, Yenny Goez-Gazi, Kendra J. Alfson, Abdul S. Yunus, Eric A. Toth, Gilad Ofek, Ricardo Carrion, Mark R. Prausnitz, Thomas R. Fuerst, Alexander K. Andrianov
Publikováno v:
Journal of Functional Biomaterials, Vol 14, Iss 1, p 16 (2022)
Ebolavirus (EBOV) infection in humans is a severe and often fatal disease, which demands effective interventional strategies for its prevention and treatment. The available vaccines, which are authorized under exceptional circumstances, use viral vec
Externí odkaz:
https://doaj.org/article/a885540978ff4542aea23a7fac2aa739
Publikováno v:
Molecules, Vol 27, Iss 21, p 7424 (2022)
The in vivo potency of polyphosphazene immunoadjuvants is inherently linked to the ability of these ionic macromolecules to assemble with antigenic proteins in aqueous solutions and form physiologically stable supramolecular complexes. Therefore, in-
Externí odkaz:
https://doaj.org/article/eccfe9bf944844bdaaaa8b261d2fb627
Autor:
James J. Steinhardt, Javier Guenaga, Hannah L. Turner, Krisha McKee, Mark K. Louder, Sijy O’Dell, Chi-I Chiang, Lin Lei, Andrey Galkin, Alexander K. Andrianov, Nicole A. Doria-Rose, Robert T. Bailer, Andrew B. Ward, John R. Mascola, Yuxing Li
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Broadly neutralizing antibodies targeting HIV Env could potentially be utilized as therapeutics. Here, Steinhardt et al. engineer a trispecific antibody with specificity for the receptor-binding site, a conserved Env glycan patch and the Env membrane
Externí odkaz:
https://doaj.org/article/03eaed1d2e664ef483d4e8852e3946e7
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1834 (2021)
Self-assembly of ionically charged small molecule drugs with water-soluble biodegradable polyelectrolytes into nano-scale complexes can potentially offer a novel and attractive approach to improving drug solubility and prolonging its half-life. Nanoa
Externí odkaz:
https://doaj.org/article/974a39141b1f4bfabaf287a1638f48df
Publikováno v:
Viruses, Vol 13, Iss 6, p 981 (2021)
Development of preventive vaccines against hepatitis C virus (HCV) remains one of the main strategies in achieving global elimination of the disease. The effort is focused on the quest for vaccines capable of inducing protective cross-neutralizing hu
Externí odkaz:
https://doaj.org/article/81d153e0c0a34f2d80a371f56504d7a6