Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Alexander James Bridges"'
Autor:
Patricia J. Harvey, Gonzales Andrea, Shannon Leigh Black, Jeff B. Smaill, Ken Hook, Florence O. McCarthy, Stephen Fakhoury, Adrian Blaser, Haile Tecle, Freddy Rivault, Tong Zhu, Brian D. Palmer, Kevin Matthew Schlosser, Jessica Elizabeth Reed, Karen Elaine Sexton, William A. Denny, Irene W. Althaus, R. Thomas Winters, Teresa Ellis, Helen Tsenwhei Lee, Andrew M. Thompson, Erin Trachet, Alexander James Bridges, Julie Ann Spicer, Paul A. Ellis
Publikováno v:
Journal of Medicinal Chemistry. 59:8103-8124
Structure-activity relationships for inhibition of erbB1, erbB2, and erbB4 were determined for a series of quinazoline- and pyrido[3,4-d]pyrimidine-based analogues of the irreversible pan-erbB inhibitor, canertinib. Cyclic amine bearing crotonamides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e41b02b5002130f3f1a0856c03fbdf
https://doi.org/10.1021/acs.jmedchem.6b00883
https://doi.org/10.1021/acs.jmedchem.6b00883
Autor:
W. Allen Howard, Joseph S. Warmus, Haile Tecle, Smith Yvonne Dorothy, Wilbur R. Leopold, Stephen Douglas Barrett, James H. Fergus, Amy M. Delaney, Dan Marston, Alan R. Saltiel, Alexander James Bridges, Sophie LePage, Annette M. Doherty, Cathlin Marie Flamme, Sally Przybranowski, Judith Sebolt-Leopold, Robert M. Kennedy, Keri Van Becelaere, David T. Dudley, Michael Kaufman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:6501-6504
A novel series of benzhydroxamate esters derived from their precursor anthranilic acids have been prepared and have been identified as potent MEK inhibitors. 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide, CI-1040, was th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ed26d3590855244ac5118ad67f79ca
https://doi.org/10.1016/j.bmcl.2008.10.054
https://doi.org/10.1016/j.bmcl.2008.10.054
Autor:
Ellen M. Dobrusin, Elizabeth A. Lunney, William A. Denny, Edward N. Baker, Andrew M. Thompson, R. John Booth, Brian D. Palmer, John Quin, Alan J. Kraker, Christopher J. Squire, Ivan Ivanovic, Daniel F. Ortwine, Ho H. Lee, Jeff B. Smaill, James M. J. Dickson, Alexander James Bridges
Publikováno v:
European Journal of Medicinal Chemistry. 43:1276-1296
A series of N-6 substituted 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones were prepared from N-substituted (5-methoxyphenyl)ethenylindoles. The target compounds were tested for their ability to inhibit the G2/M cell cycle checkpoint kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98017342f5dd35f584a09baa12e3d433
https://doi.org/10.1016/j.ejmech.2007.07.016
https://doi.org/10.1016/j.ejmech.2007.07.016
Autor:
James M. Nelson, Danielle M. Amato, William A. Denny, Patricia J. Harvey, Veronica Sherwood, R. Thomas Winters, David W. Fry, Sylvester R. Klutchko, Jeff B. Smaill, Zhou Hairong, Paul A. Ellis, Hyo Kyung Han, Mary Ann Meade, Gerry Pace, H. D. Hollis Showalter, Tuan P. Tran, William L. Elliott, Billy J. Roberts, Irene W. Althaus, Alexander James Bridges, Andrea J. Gonzales
Publikováno v:
Journal of Medicinal Chemistry. 49:1475-1485
Structure-activity relationships for inhibition of erbB1, erbB2, and erbB4 were determined for a series of alkynamide analogues of quinazoline- and pyrido[3,4-d]pyrimidine-based compounds. The compounds were prepared by coupling the appropriate 6-ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21abfede32f22f167677e3f652089d6a
https://doi.org/10.1021/jm050936o
https://doi.org/10.1021/jm050936o
Autor:
Alexander James Bridges, Rasmy Talaat, William F. Pool, Kan He, Michael D. Reily, Thomas F. Woolf, Jessica Elizabeth Reed
Publikováno v:
Drug Metabolism and Disposition. 32:639-646
Troglitazone (TGZ), the first glitazone used for the treatment of type II diabetes mellitus and removed from the market for liver toxicity, was shown to bind covalently to microsomal protein and glutathione (GSH) following activation by cytochrome P4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f4a079abf9fbd92b15e833a93ad2bd
https://doi.org/10.1124/dmd.32.6.639
https://doi.org/10.1124/dmd.32.6.639
Autor:
Alexander James Bridges
Publikováno v:
Chemical Reviews. 101:2541-2572
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345e9bc41ed890439c06ac6eaac86790
https://doi.org/10.1021/cr000250y
https://doi.org/10.1021/cr000250y
Autor:
David W. Fry, William L. Elliott, Patrick W. Vincent, Dennis J. McNamara, Jeff B. Smaill, William A. Denny, Zhou Hairong, James M. Nelson, H. D. Hollis Showalter, Veronika Sherwood, Bill J. Roberts, Alexander James Bridges
Publikováno v:
Journal of Medicinal Chemistry. 44:429-440
4-Anilinoquinazoline- and 4-anilinopyrido[3,4-d]pyrimidine-6-acrylamides are potent pan-erbB tyrosine kinase inactivators, and one example (CI-1033) is in clinical trial. A series of analogues with a variety of Michael acceptor units at the 6-positio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d10c67de11114be6a17fc2c444dea44
https://doi.org/10.1021/jm000372i
https://doi.org/10.1021/jm000372i
Autor:
Ellen Myra Dobrusin, James M. Nelson, Kenneth E. Hook, Alexander James Bridges, Dennis Joseph Mcnamara, David W. Fry, Susanne Trumpp-Kallmeyer, Joseph A. Loo, Veronika Sherwood, Wilbur R. Leopold, James L. Hicks, Paul R. Keller, Kenneth D. Greis, William A. Denny, Annette Marian Doherty, Jeff B. Smaill
Publikováno v:
Proceedings of the National Academy of Sciences. 95:12022-12027
A class of high-affinity inhibitors is disclosed that selectively target and irreversibly inactivate the epidermal growth factor receptor tyrosine kinase through specific, covalent modification of a cysteine residue present in the ATP binding pocket.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea16a2a86b4700b22a20c567f23b248
https://doi.org/10.1073/pnas.95.20.12022
https://doi.org/10.1073/pnas.95.20.12022
Autor:
James M. Nelson, Gordon W. Rewcastle, David W. Fry, Hairong Zhou, William A. Denny, Veronika Slintak, Paul R. Keller, Alexander James Bridges
Publikováno v:
Biochemical Pharmacology. 54:877-887
The tyrosine kinase inhibitors PD 69896, 153717, and 158780, which belong to the chemical class 4-[ar(alk)ylamino]pyridopyrimidines, have been characterized with respect to enzymology, target specificity, and antiproliferative effects in tumor cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e167522c81e41850a387d11a9aaa63
https://doi.org/10.1016/s0006-2952(97)00242-6
https://doi.org/10.1016/s0006-2952(97)00242-6
Autor:
Alexander James Bridges, Hairong Zhou
Publikováno v:
Journal of Heterocyclic Chemistry. 34:1163-1172
Various 2-fluorobenzonitriles were converted to the corresponding 3-amino[1]benzothiophenecarboxylic acid esters, which in turn were annulated with formamidine or various equivalents to produce the desired tricyclic benzothienopyrimidines. Various me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9b5aa4d286431b0d4e7927646dbcdff
https://doi.org/10.1002/jhet.5570340412
https://doi.org/10.1002/jhet.5570340412