Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Alexander J. Whittam"'
Autor:
Robert C. Rennert, Michael Januszyk, Michael Sorkin, Melanie Rodrigues, Zeshaan N. Maan, Dominik Duscher, Alexander J. Whittam, Revanth Kosaraju, Michael T. Chung, Kevin Paik, Alexander Y. Li, Michael Findlay, Jason P. Glotzbach, Atul J. Butte, Geoffrey C. Gurtner
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Unrecognized progenitor cell perturbations underlying a disease state may limit the efficacy of cell therapies. Here, the authors use high-throughput, single-cell transcriptional analysis to identify disease-specific cellular alterations and prospect
Externí odkaz:
https://doaj.org/article/e3e19ba12cdd407ca10537b23a1ba94c
Autor:
Kevin J Paik, Zeshaan N Maan, Elizabeth R Zielins, Dominik Duscher, Alexander J Whittam, Shane D Morrison, Elizabeth A Brett, Ryan C Ransom, Michael S Hu, Joseph C Wu, Geoffrey C Gurtner, Michael T Longaker, Derrick C Wan
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150927 (2016)
The transcription factor hypoxia-inducible factor 1-alpha (HIF-1α) is responsible for the downstream expression of over 60 genes that regulate cell survival and metabolism in hypoxic conditions as well as those that enhance angiogenesis to alleviate
Externí odkaz:
https://doaj.org/article/0de5ca85e50645049a47832d6b972d15
Autor:
Clark A. Bonham, Alexander J. Whittam, Dominik Duscher, Jayakumar Rajadas, Geoffrey C. Gurtner, Karl Engel, Zachary A. Stern-Buchbinder, Artem A. Trotsyuk, Mohammed Inayathullah, Janos A. Barrera, Michael S. Hu, Zeshaan N. Maan, Melanie Rodrigues, Sun Hyung Kwon
Publikováno v:
Journal of Controlled Release. 308:232-239
Chronic wounds remain a significant burden to both the healthcare system and individual patients, indicating an urgent need for new interventions. Deferoxamine (DFO), an iron-chelating agent clinically used to treat iron toxicity, has been shown to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701f5f87932c974972752a3c2b9c9518
https://doi.org/10.1016/j.jconrel.2019.07.009
https://doi.org/10.1016/j.jconrel.2019.07.009
Autor:
Zeshaan N. Maan, Dominik Duscher, Janos A. Barrera, Victor W. Wong, Sacha M.L. Khong, Ferdinando Giacco, Michael T. Longaker, Michael Brownlee, Michael Januszyk, Michael S. Hu, Sun Hyung Kwon, Graham G. Walmsley, Lauren H. Fischer, Geoffrey C. Gurtner, Alexander J. Whittam
Publikováno v:
Transl Res
In diabetes, stromal cell-derived factor-1 (SDF-1) expression and progenitor cell recruitment are reduced. Dipeptidyl peptidase-4 (DPP-4) inhibits SDF-1 expression and progenitor cell recruitment. Here we examined the impact of the DPP-4 inhibitor, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73033cabc0dfb72425ae3f686f9939d5
https://doi.org/10.1016/j.trsl.2018.10.006
https://doi.org/10.1016/j.trsl.2018.10.006
Autor:
Geoffrey C. Gurtner, Lauren H. Fischer, Robert C. Rennert, Dharshan Sivaraj, Michael T. Longaker, Michael Januszyk, Zeshaan N. Maan, Alexander J. Whittam, Jagannath Padmanabhan, Dominic Henn, Kellen Chen, Wing Lam Natalie Ho, Johannes Riegler, Ivan N. Vial, Joseph C. Wu, Janos A. Barrera, Michael S. Hu, Dominik Duscher
Publikováno v:
SSRN Electronic Journal.
CXC chemokine ligand 12 (CXCL12; stromal cell-derived factor 1 [SDF-1]), primarily known for its role in embryogenesis and hematopoiesis, has also been implicated in tumor biology and neovascularization. However, its specific role and mechanism of ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f4c8a641290bd272da7436cdcb23a4d
https://doi.org/10.2139/ssrn.3809993
https://doi.org/10.2139/ssrn.3809993
Autor:
Robert C. Rennert, Zeshaan N. Maan, Michael S. Hu, Michael T. Longaker, Johannes Riegler, Jagannath Padmanabhan, Natalie Ho, Dominik Duscher, Geoffrey C. Gurtner, Michael Januszyk, Alexander J. Whittam, Joseph C. Wu, Janos A. Barrera, Lauren H. Fischer, Ivan N. Vial
CXC chemokine ligand 12 (CXCL12; stromal cell-derived factor 1 [SDF-1]), primarily known for its role in embryogenesis and hematopoiesis, has also been implicated in tumor biology and neovascularization. However, its specific role and mechanism of ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffafae41cb858a413e84159e5adc4f84
https://doi.org/10.1101/2020.05.24.113845
https://doi.org/10.1101/2020.05.24.113845
Autor:
Sacha M.L. Khong, Michael T. Longaker, Yixiao Dong, Graham G. Walmsley, Geoffrey C. Gurtner, Alexander J. Whittam, Michael S. Hu, Dominik Duscher, Zeshaan N. Maan, Michael Januszyk
Publikováno v:
Plastic and Reconstructive Surgery. 139:695e-706e
Background:A hallmark of diabetes mellitus is the breakdown of almost every reparative process in the human body, leading to critical impairments of wound healing. Stabilization and activity of the transcription factor hypoxia-inducible factor (HIF)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70b2e0d703e5bcd36f26b305b29821b0
https://doi.org/10.1097/prs.0000000000003072
https://doi.org/10.1097/prs.0000000000003072
Autor:
Toshihiro Fujiwara, Kristine C. Rustad, Geoffrey C. Gurtner, Michael Januszyk, Revanth Kosaraju, Melanie Rodrigues, Alexander J. Whittam, Zeshaan N. Maan, Dominik Duscher
Publikováno v:
Experimental Dermatology. 25:206-211
Advanced age is characterized by impairments in wound healing, and evidence is accumulating that this may be due in part to a concomitant increase in oxidative stress. Extended exposure to reactive oxygen species (ROS) is thought to lead to cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141872773d599494a6f4da175d4fccae
https://doi.org/10.1111/exd.12909
https://doi.org/10.1111/exd.12909
Autor:
Geoffrey C. Gurtner, Michael Januszyk, Alexander J. Whittam, Dominik Duscher, Zeshaan N. Maan, Janos A. Barrera, Victor W. Wong
Publikováno v:
Advances in Wound Care. 5:79-88
Significance: Chronic wounds remain a significant public health problem. Alterations in normal physiological processes caused by aging or diabetes lead to impaired tissue repair and the development of chronic and nonhealing wounds. Understanding the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9cf2ece55083760bd38467e83a5e0d
https://doi.org/10.1089/wound.2014.0600
https://doi.org/10.1089/wound.2014.0600
Autor:
Anna Luan, Derrick C. Wan, Gordon K. Lee, Elizabeth R. Zielins, Dominik Duscher, Geoffrey C. Gurtner, Alexander J. Whittam, Kevin J. Paik, Elizabeth A. Brett, Michael T. Longaker, Michael S. Hu, David Atashroo
Publikováno v:
Stem Cells. 34:668-673
Radiation therapy is not only a mainstay in the treatment of many malignancies but also results in collateral obliteration of microvasculature and dermal/subcutaneous fibrosis. Soft tissue reconstruction of hypovascular, irradiated recipient sites th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9071a2e00b4a64c1b6f7e767f17da5e4
https://doi.org/10.1002/stem.2256
https://doi.org/10.1002/stem.2256