Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alexander J. Trostle"'
Autor:
Alexander J. Trostle, Lucian Li, Seon-Young Kim, Jiasheng Wang, Rami Al-Ouran, Hari Krishna Yalamanchili, Zhandong Liu, Ying-Wooi Wan
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5122 (2023)
Mutations in MeCP2 result in a crippling neurological disease, but we lack a lucid picture of MeCP2′s molecular role. Individual transcriptomic studies yield inconsistent differentially expressed genes. To overcome these issues, we demonstrate a me
Externí odkaz:
https://doaj.org/article/de8b6088d472438d99305530e7b1f0c1
Autor:
Laura A Lavery, Kerstin Ure, Ying-Wooi Wan, Chongyuan Luo, Alexander J Trostle, Wei Wang, Haijing Jin, Joanna Lopez, Jacinta Lucero, Mark A Durham, Rosa Castanon, Joseph R Nery, Zhandong Liu, Margaret Goodell, Joseph R Ecker, M Margarita Behrens, Huda Y Zoghbi
Publikováno v:
eLife, Vol 9 (2020)
Methylated cytosine is an effector of epigenetic gene regulation. In the brain, Dnmt3a is the sole ‘writer’ of atypical non-CpG methylation (mCH), and MeCP2 is the only known ‘reader’ for mCH. We asked if MeCP2 is the sole reader for Dnmt3a d
Externí odkaz:
https://doaj.org/article/b078fc09c47f4ff18e2e3557478a806d
Autor:
Sameer S. Bajikar, Ashley G. Anderson, Jian Zhou, Mark A. Durham, Alexander J. Trostle, Ying-Wooi Wan, Zhandong Liu, Huda Y. Zoghbi
Publikováno v:
eLife. 12
Loss- and gain-of-function of MeCP2 causes Rett syndrome (RTT) and MECP2 duplication syndrome (MDS), respectively. MeCP2 binds methyl-cytosines to finely tune gene expression in the brain, though identifying genes robustly regulated by MeCP2 has been
Researchers handicap their high-throughput sequencing experiments when they do not perform enough biological replicates. Given that biological tissues can be highly variable, too few replicates will lead to false negatives, false positives, irreprodu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a12c23502a5f62c233366917a98cd5a3
https://doi.org/10.1101/2022.08.03.502688
https://doi.org/10.1101/2022.08.03.502688
Autor:
Stephanie L. Coffin, Mark A. Durham, Larissa Nitschke, Eder Xhako, Amanda M. Brown, Jean-Pierre Revelli, Esmeralda Villavicencio Gonzalez, Tao Lin, Hillary P. Handler, Yanwan Dai, Alexander J. Trostle, Ying-Wooi Wan, Zhandong Liu, Roy V. Sillitoe, Harry T. Orr, Huda Y. Zoghbi
Publikováno v:
Neuron. 111:481-492.e8
Spinocerebellar ataxia type 1 (SCA1) is a paradigmatic neurodegenerative disease in that it is caused by a mutation in a broadly expressed protein, ATXN1; however, only select populations of cells degenerate. The interaction of polyglutamine-expanded
Autor:
Lucian Li, Hari Krishna Yalamanchili, Ying-Wooi Wan, Jiasheng Wan, Zhandong Liu, Seon-Youn Kim, Rami Al-Ouran, Alexander J. Trostle
SummaryMutations in MeCP2 result in a crippling neurological disease, but we lack a lucid picture of MeCP2s molecular role. Focusing on individual transcriptomic studies yields inconsistent differentially expressed genes. We have aggregated and homog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a59745610dfb0c05197359d1901ada32
https://doi.org/10.1101/2021.11.27.470197
https://doi.org/10.1101/2021.11.27.470197
Autor:
Sameer S. Bajikar, Frank Rigo, Jianrong Tang, Qi Wang, Huda Y. Zoghbi, Yingyao Shao, Paymaan Jafar-Nejad, Ying-Wooi Wan, Alexander J. Trostle, Zhandong Liu, Yehezkel Sztainberg
Publikováno v:
Science Translational Medicine. 13
Many intellectual disability disorders are due to copy number variations, and, to date, there have been no treatment options tested for this class of diseases. MECP2 duplication syndrome (MDS) is one of the most common genomic rearrangements in males
Autor:
Jacinta Lucero, Joseph R. Ecker, M. Margarita Behrens, Chongyuan Luo, Margaret A. Goodell, Alexander J. Trostle, Kerstin Ure, Joseph R. Nery, Huda Y. Zoghbi, Rosa Castanon, Zhandong Liu, Haijing Jin, Joanna Lopez, Ying-Wooi Wan, Wei Wang, Mark A Durham, Laura A. Lavery
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Methylated cytosine is an effector of epigenetic gene regulation. In the brain, Dnmt3a is the sole ‘writer’ of atypical non-CpG methylation (mCH), and MeCP2 is the only known ‘reader’ for mCH. We asked if MeCP2 is the sole reader for Dnmt3a d
Autor:
Alexander J. Trostle, Joseph R. Ecker, Laura A. Lavery, Wei Wang, Joseph R. Nery, Jacinta Lucero, Rosa Castanon, Zhandong Liu, Haijing Jin, Huda Y. Zoghbi, Chongyuan Luo, Ying-Wooi Wan, Margaret A. Goodell, Joanna Lopez, M. Margarita Behrens, Kerstin Ure, Mark A Durham
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a2411cb8fba6e96a9d4fdbabb5277dd
https://doi.org/10.7554/elife.52981.sa2
https://doi.org/10.7554/elife.52981.sa2