Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Alexander J. Szubert"'
Autor:
Katrina M. Pollock, Hannah M. Cheeseman, Alexander J. Szubert, Vincenzo Libri, Marta Boffito, David Owen, Henry Bern, Jessica O'Hara, Leon R. McFarlane, Nana-Marie Lemm, Paul F. McKay, Tommy Rampling, Yee Ting N. Yim, Ana Milinkovic, Cherry Kingsley, Tom Cole, Susanne Fagerbrink, Marites Aban, Maniola Tanaka, Savviz Mehdipour, Alexander Robbins, William Budd, Saul N. Faust, Hana Hassanin, Catherine A. Cosgrove, Alan Winston, Sarah Fidler, David T. Dunn, Sheena McCormack, Robin J. Shattock
Publikováno v:
EClinicalMedicine, Vol 44, Iss , Pp 101262- (2022)
Summary: Background: Lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is a novel technology formulated as a low dose vaccine against COVID-19. Methods: A phase I first-in-human dose-ranging trial of a saRNA COVID-19 vaccine candidate
Externí odkaz:
https://doaj.org/article/59824dcfc367459c9e970a7c3996b40c
Autor:
Ruth M. de Tute, Andy C. Rawstron, Walter M. Gregory, J. Anthony Child, Faith E. Davies, Sue E. Bell, Gordon Cook, Alexander J. Szubert, Mark T. Drayson, Graham H. Jackson, Gareth J. Morgan, Roger G. Owen
Publikováno v:
Haematologica, Vol 101, Iss 2 (2016)
Externí odkaz:
https://doaj.org/article/60d5de834006459097fe542a146e6694
Autor:
Gareth J. Morgan, Faith E. Davies, Walter M. Gregory, Sue E. Bell, Alexander J. Szubert, Nuria Navarro Coy, Gordon Cook, Sylvia Feyler, Peter R.E. Johnson, Claudius Rudin, Mark T. Drayson, Roger G. Owen, Fiona M. Ross, Nigel H. Russell, Graham H. Jackson, J. Anthony Child
Publikováno v:
Haematologica, Vol 97, Iss 3 (2012)
Background Thalidomide is active in multiple myeloma and is associated with minimal myelosuppression, making it a good candidate for induction therapy prior to high-dose therapy with autologous stem-cell transplantation.Design and Methods Oral cyclop
Externí odkaz:
https://doaj.org/article/041499dacc9f47dd98b2ea06bd51cabf
Autor:
Nigel Klein, A. Kekitiinwa, Andrew J. Prendergast, Annie Shonhai, Mutsa Bwakura-Dangarembizi, Chipo Berejena, A S Walker, Patricia Nahirya-Ntege, Moira J. Spyer, Alexander J. Szubert, Godfrey Pimundu, Adrian Cook, DM Gibb, Victor Musiime
Publikováno v:
AIDS. 33:1485-1490
Objectives: A proportion of HIV-infected children with advanced disease develop severe malnutrition soon after antiretroviral therapy (ART) initiation. We tested the hypothesis that systemic inflammation underlies the pathogenesis of severe malnutrit
Autor:
Pietro Pala, Macklyn Kihembo, Patricia Hunter, Moira J. Spyer, Paula Munderi, Godfrey Pimundu, Andrew J. Prendergast, Chipo Berejena, Alexander J. Szubert, Diana M. Gibb, Hannah Poulsom, Annie Shonhai, Nigel Klein, A. Sarah Walker, Victor Musiime, Mutsa Bwakura-Dangarembizi, Francesca Arrigoni, Philippa Musoke
Publikováno v:
AIDS
Objective To determine the impact of virological control on inflammation and cluster of differentiation 4 depletion among HIV-infected children initiating antiretroviral therapy (ART) in sub-Saharan Africa. Design Longitudinal cohort study. Methods I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21728052c3d3253d82a98802e0d8a063
https://ora.ox.ac.uk/objects/uuid:13de3092-3c74-46a3-979d-0a5ecfdce8da
https://ora.ox.ac.uk/objects/uuid:13de3092-3c74-46a3-979d-0a5ecfdce8da
Autor:
Chipo Berejena, Diana M. Gibb, Naheed Choudhry, Ethan K. Gough, Nigel Klein, Amee R. Manges, Joseph Lutaakome, Godfrey Pimundu, Louise Terry, Andrew J. Prendergast, A. Sarah Walker, Thaddeus J. Edens, Yusuf Karmali, Kuda Mutasa, Hyun Min Geum, Claire D. Bourke, Moira J. Spyer, Alexander J. Szubert, Claire Pardieu, Magdalena Glass, Adeodata Kekitiinwa, Victor Musiime, Jane R. Deayton, Annie Shonhai, Mutsa Bwakura-Dangarembizi, Lucas Baumard
Publikováno v:
Science Translational Medicine. 11(486)
Long-term cotrimoxazole prophylaxis reduces mortality and morbidity in HIV infection but the mechanisms underlying these sustained clinical benefits are unclear. Here we investigate the impact of cotrimoxazole on systemic inflammation, an independent
Autor:
Cissy Kityo, Alexander J Szubert, Abraham Siika, Robert Heyderman, Mutsa Bwakura-Dangarembizi, Abbas Lugemwa, Shalton Mwaringa, Anna Griffiths, Immaculate Nkanya, Sheila Kabahenda, Simon Wachira, Godfrey Musoro, Chatu Rajapakse, Timothy Etyang, James Abach, Moira J Spyer, Priscilla Wavamunno, Linda Nyondo-Mipando, Ennie Chidziva, Kusum Nathoo, Nigel Klein, James Hakim, Diana M Gibb, A Sarah Walker, Sarah L Pett, REALITY trial team
Publikováno v:
PLoS Medicine, Vol 15, Iss 12, p e1002706 (2018)
BackgroundIn sub-Saharan Africa, individuals infected with HIV who are severely immunocompromised have high mortality (about 10%) shortly after starting antiretroviral therapy (ART). This group also has the greatest risk of morbidity and mortality as
Autor:
Dakshika Jeyaratnam, Achyut Guleri, Denise Ward, Gonzalez-Ruiz Armando, Martin Wiselka, Julia Greig, Clive Graham, R. Cunningham, Bernadette C. Young, David Harvey, Jonathan D. Edgeworth, Paul R. Chadwick, Matthew Scarborough, Janet Cairns, Guy E. Thwaites, Robert Tilley, Julian Sutton, M. Estée Török, Paul McWhinney, John Williams, Peter R. Wilson, A. Sarah Walker, Deepa Nayar, Pankaj Lal, Gavin Barlow, Emmanuel Nsutebu, Marta Soares, Neil Jenkins, Alexander J. Szubert, Pedro Saramago Goncalves, Sarah A Wyllie, Jennifer Bostock, Cressida Auckland, David Price, Jane Minton, N. Claire Gordon, Susan Hopkins, Sarah Meisner, T. Planche, Fleur Hudson, Martin J. Llewelyn
Publikováno v:
Health Technology Assessment, Vol 22, Iss 59 (2018)
BackgroundStaphylococcus aureusbacteraemia is a common and frequently fatal infection. Adjunctive rifampicin may enhance earlyS. aureuskilling, sterilise infected foci and blood faster, and thereby reduce the risk of dissemination, metastatic infecti
Publikováno v:
Lancet. 392(10147)
Autor:
A. Sarah Walker, Godfrey Musoro, Felicity Fitzgerald, Helen Wilkes, Sarah Pett, Andrew J. Prendergast, Victor Musiime, Frank A. Post, Diana M. Gibb, Peter Mugyenyi, Clara A. Agutu, Hermione Lyall, Priscilla Chepkorir, Alexander J. Szubert, Chathurika Rajapakse, James Hakim, Jane Mallewa, Victoria Johnston, children starting antiretroviral therapy (Reality) Trial Team
Publikováno v:
S139
S132
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
S132
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Background: In sub-Saharan Africa, 20%-25% of people starting ART have severe immunosuppression; ~10% die within three months. In the recently-reported REALITY randomized trial, a broad enhanced anti-infection prophylaxis bundle reduced all-cause mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a009f4643f4f62bfa41c7cd306a1d433
https://researchonline.lshtm.ac.uk/id/eprint/4646934/1/Causes-and-Timing-of-Mortality-and-Morbidity-Among-Late-Presenters-Starting-Antiretroviral-Therapy-in-the-REALITY-Trial.pdf
https://researchonline.lshtm.ac.uk/id/eprint/4646934/1/Causes-and-Timing-of-Mortality-and-Morbidity-Among-Late-Presenters-Starting-Antiretroviral-Therapy-in-the-REALITY-Trial.pdf