Alpha-synuclein supports type 1 interferon signalling in neurons and brain tissue

Autor: Brendan Monogue, Yixi Chen, Hadrian Sparks, Ranya Behbehani, Andrew Chai, Alexander J Rajic, Aaron Massey, B K Kleinschmidt-Demasters, Matthieu Vermeren, Tilo Kunath, J David Beckham

Publikováno v: Brain
Monogue, B, Chen, Y, Sparks, H, Behbehani, R, Chai, A, Rajic, A J, Massey, A, Kleinschmidt-Demasters, B K, Vermeren, M, Kunath, T & Beckham, J D 2022, ' Alpha-synuclein supports type 1 interferon signalling in neurons and brain tissue ', Brain, vol. 145, no. 10, awac192, pp. 3622-3636 . https://doi.org/10.1093/brain/awac192

The protein alpha-synuclein is predominantly expressed in neurons and is associated with neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. However, the normal function of alpha-synuclein in neurons is not clearly de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6b8d3b8d3afecbefc907174fed8bd7
https://pubmed.ncbi.nlm.nih.gov/35858675

Use of coffee grounds to test olfaction for predicting cognitive dysfunction and decline

Autor: Heidi J. Chial, Alexander J. Rajic, Jonathan H. Woodcock, Christopher M. Filley, Peter Pressman

Publikováno v: J Neurol Sci

Introduction Our objective was to determine whether non-standardized testing of olfaction may provide useful information for predicting cognitive dysfunction and decline in patients with neurobehavioral disorders. Methods We conducted cross-sectional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c11a71d21e7eec42706a3d4147f5560
https://doi.org/10.1016/j.jns.2021.117516

P1‐491: COMPARATIVE ANALYSIS OF CLINICOPATHOLOGICAL THRESHOLD MODELING USING QUANTITATIVE NFT LOADS, VASCULAR DISEASE, AND AGE‐RELATED GLIOSIS AGAINST BRAAK TANGLE STAGE IN PURE ALZHEIMER DISEASE AUTOPSY CASES

Autor: Alexander J. Rajic, Wayne W. Poon, Peter Pressman

Publikováno v: Alzheimer's & Dementia. 14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ff6b9594e51b4a638142a630f501e41
https://doi.org/10.1016/j.jalz.2018.06.501

ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology

Autor: Randall L. Woltjer, Li-San Wang, Jonathan L. Haines, Ishita Parikh, Julie A. Schneider, Paul K. Crane, Erin L. Abner, Craig Horbinski, Manasi Malik, Maria M. Corrada, Amanda Partch, KatieRose Richmire, Peter T. Nelson, Sarah E. Monsell, Gregory A. Jicha, Richard Mayeux, David H. Cribbs, Claudia H. Kawas, Bernard R. Wilfred, Kannabiran Nandakumar, David W. Fardo, Margaret A. Pericak-Vance, Leonard W. Poon, Steven Estus, Eric B. Larson, Richard J. Kryscio, Lindsay A. Farrer, Alexander J. Rajic, Thomas J. Montine, Otto Valladares, Wayne W. Poon, Wang-Xia Wang, Frederick A. Schmitt, Robert C. Green, Walter A. Kukull, Gerard D. Schellenberg, Marla Gearing, Linda J. Van Eldik, Mark L. Farman, Joshua A. Sonnen, Eseosa T. Ighodaro, Charles D. Smith, Stephen W. Scheff, Patricia L. Kramer, Janna H. Neltner, David A. Bennett

Publikováno v: Nelson, PT; Estus, S; Abner, EL; Parikh, I; Malik, M; Neltner, JH; et al.(2014). ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta Neuropathologica, 127(6), 825-843. doi: 10.1007/s00401-014-1282-2. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4fr967hw

Hippocampal sclerosis of aging (HS-Aging) is a high-morbidity brain disease in the elderly but risk factors are largely unknown. We report the first genome-wide association study (GWAS) with HS-Aging pathology as an endophenotype. In collaboration wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0678fe7e51f00665e8797315c3167c1b
https://doi.org/10.1007/s00401-014-1282-2

Control of cytochrome c redox reactivity through off-pathway modifications in the protein hydrogen-bonding network

Autor: Soyeun Yang, Alexander J. Rajic, Jie Gu, Ekaterina V. Pletneva, Tatiana R. Prytkova, Igor V. Kurnikov

Publikováno v: Chemical communications (Cambridge, England). 50(40)

Measurements of photoinduced Fe(2+)-to-Ru(3+) electron transfer (ET), supported by theoretical analysis, demonstrate that mutations off the dominant ET pathways can strongly influence the redox reactivity of cytochrome c. The effects arise from the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bfec12ba75471afe00f7b25bdd19c3
https://pubmed.ncbi.nlm.nih.gov/24413285