Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alexander J. Lakhter"'
Autor:
Mani Shankar Babu, Sailendra Mahanta, Alexander J Lakhter, Takashi Hato, Subhankar Paul, Samisubbu R Naidu
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191419 (2018)
Reliance on aerobic glycolysis is one of the hallmarks of cancer. Although pyruvate kinase M2 (PKM2) is a key mediator of glycolysis in cancer cells, lack of selective agents that target PKM2 remains a challenge in exploiting metabolic pathways for c
Externí odkaz:
https://doaj.org/article/d1196c6715c04e1e9b875ed9e709c272
Autor:
Bernhard Maier, Rachel E. Pratt, Emily K. Sims, Linda A. DiMeglio, Rachel E. Moore, Kaitlin K. Doucette, Alexander J. Lakhter
Publikováno v:
Diabetologia. 61:1124-1134
AIMS/HYPOTHESIS: Improved biomarkers are acutely needed for the detection of developing type 1 diabetes, prior to critical loss of beta cell mass. We previously demonstrated that elevated beta cell microRNA 21 (miR-21-5p) in rodent and human models o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c397f5e1cf4992ac9c9a29eef23e8de6
https://doi.org/10.1007/s00125-018-4559-5
https://doi.org/10.1007/s00125-018-4559-5
Autor:
Alexander J. Lakhter, Emily Anderson-Baucum, Tatsuyoshi Kono, Emily K. Sims, Xin Tong, Carmella Evans-Molina
Publikováno v:
Diabetologia. 60:1057-1065
The role of beta cell microRNA (miR)-21 in the pathophysiology of type 1 diabetes has been controversial. Here, we sought to define the context of beta cell miR-21 upregulation in type 1 diabetes and the phenotype of beta cell miR-21 overexpression t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d620b16fbb316f59e44056cd5eb0b8
https://doi.org/10.1007/s00125-017-4237-z
https://doi.org/10.1007/s00125-017-4237-z
Autor:
James Hamilton, Nickolay Brustovetsky, Samisubbu R. Naidu, Hal E. Broxmeyer, Raymond L. Konger, Alexander J. Lakhter
Publikováno v:
Journal of Biological Chemistry. 291:21869-21879
Tumors rely on multiple nutrients to meet cellular bioenergetics and macromolecular synthesis demands of rapidly dividing cells. Although the role of glucose and glutamine in cancer metabolism is well understood, the relative contribution of acetate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a4d07bb8dabbe02250411c8b4208bf
https://doi.org/10.1074/jbc.m115.712166
https://doi.org/10.1074/jbc.m115.712166
Autor:
Subhankar Paul, Sailendra Mahanta, Alexander J. Lakhter, Mani Shankar Babu, Samisubbu R. Naidu, Takashi Hato
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 2, p e0191419 (2018)
PLoS ONE, Vol 13, Iss 2, p e0191419 (2018)
Reliance on aerobic glycolysis is one of the hallmarks of cancer. Although pyruvate kinase M2 (PKM2) is a key mediator of glycolysis in cancer cells, lack of selective agents that target PKM2 remains a challenge in exploiting metabolic pathways for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348faba0b5fa0cefc9d042ea7df54c67
http://europepmc.org/articles/PMC5796696
http://europepmc.org/articles/PMC5796696
Autor:
Emily K. Sims, Alexander J. Lakhter
Publikováno v:
Molecular Endocrinology. 29:1535-1548
Extracellular vesicles (EVs), membrane-contained vesicles released by most cell types, have attracted a large amount of research interest over the past decade. Because of their ability to transfer cargo via regulated processes, causing functional imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a81c48c9893a803d89fc331ab96972
https://doi.org/10.1210/me.2015-1206
https://doi.org/10.1210/me.2015-1206
Publikováno v:
Journal of Cellular Biochemistry. 117:853-859
Hypoxia-inducible factor-1alpha (HIF1a) is a key transcriptional regulator that enables cellular metabolic adaptation to low levels of oxygen. Multiple mechanisms, including lysosomal degradation, control the levels of HIF1a protein. Here we show tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98903f76b3ad422e0b9469d06accf5d9
https://doi.org/10.1002/jcb.25381
https://doi.org/10.1002/jcb.25381
Autor:
Alexander J. Lakhter, Emily Anderson-Baucum, Raghavendra G. Mirmira, Emily K. Sims, Yukio Tanizawa, Bernhard Maier, Carmella Evans-Molina, Masayuki Hatanaka, Sarah A. Tersey, Tatsuyoshi Kono
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Under conditions of high fat diet (HFD) consumption, glucose dyshomeostasis develops when β-cells are unable to adapt to peripheral insulin demands. Few studies have interrogated the molecular mechanisms of β-cell dysfunction at the level of mRNA t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bedd6bb1eb45c0685d3cf9311900bcc
http://europepmc.org/articles/PMC5476640
http://europepmc.org/articles/PMC5476640
Publikováno v:
Melanoma research. 27(5)
The universal second messenger cAMP regulates numerous cellular processes. Although the cAMP-signaling pathway leads to induction of gene transcription, it remains unknown whether this pathway contributes toward suppression of transcription. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a63e444d377bd131e5eee317afef7fb
https://pubmed.ncbi.nlm.nih.gov/28489680
https://pubmed.ncbi.nlm.nih.gov/28489680
Autor:
James Hamilton, Robert A. Harris, Samisubbu R. Naidu, Takashi Hato, Lindsey D. Mayo, Mircea Ivan, Anantha Shekhar, X. Charlie Dong, Alexander J. Lakhter, Suresh Mukkamala, Pierre C. Dagher, Nickolay Brustovetsky
Publikováno v:
Oncotarget
Reliance on glycolysis is a characteristic of malignancy, yet the development of resistance to BRAF inhibitors in melanoma is associated with gain of mitochondrial function. Concurrent attenuation of oxidative phosphorylation and HIF-1α/PKM2-depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35498d1eb2b6819a92ca73abb78cc73c
https://doi.org/10.18632/oncotarget.3031
https://doi.org/10.18632/oncotarget.3031