Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Alexander J. Debets"'
Publikováno v:
Biochemical Pharmacology. 35:3693-3699
The effects of 3-monoalkyl- and 3,5-dialkyl-substitution on the cytotoxicity of paracetamol (PAR) in rat hepatocytes was studied. PAR is known to be bioactivated by the hepatic microsomal cytochrome P-450 containing a mixed-function oxidase system pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29f4d4d5f69e16a5a74510312034eecf
https://doi.org/10.1016/0006-2952(86)90653-2
https://doi.org/10.1016/0006-2952(86)90653-2
Publikováno v:
Biochemical Pharmacology. 36:2065-2070
Recently, we have reported that 3,5-dialkyl substitution of paracetamol, in contrast to 3-monoalkyl substitution, prevented the paracetamol-induced toxicity in freshly isolated rat hepatocytes without having any effect on its cytochrome P-450 mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ee6869b5462107e0dce863331e15964
https://doi.org/10.1016/0006-2952(87)90132-8
https://doi.org/10.1016/0006-2952(87)90132-8
Publikováno v:
Debets, A J, Van de Straat, R, Voogt, T W, Vos, H, Vermeulen, N P & Frei, R W 1988, ' Simultaneous determination of glutathione, glutathione disulphide, paracetamol and its sulphur containing metabolites using HPLC and electrochemical detection with
generated bromine ', Journal of Pharmaceutical and Biomedical Analysis, vol. 6, no. 3, pp. 329-36 . https://doi.org/10.1016/0731-7085(88)80061-X
Journal of Pharmaceutical and Biomedical Analysis, 6(3), 329-36. Elsevier
generated bromine ', Journal of Pharmaceutical and Biomedical Analysis, vol. 6, no. 3, pp. 329-36 . https://doi.org/10.1016/0731-7085(88)80061-X
Journal of Pharmaceutical and Biomedical Analysis, 6(3), 329-36. Elsevier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f59233eaa2f210181dd5b5101f155e3
https://hdl.handle.net/1871.1/a771c4b3-2b3b-426d-864f-0ae1ab2fda3e
https://hdl.handle.net/1871.1/a771c4b3-2b3b-426d-864f-0ae1ab2fda3e