Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Alexander J Ruthenburg"'
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 10, p e1011576 (2023)
Long-read RNA sequencing has arisen as a counterpart to short-read sequencing, with the potential to capture full-length isoforms, albeit at the cost of lower depth. Yet this potential is not fully realized due to inherent limitations of current long
Externí odkaz:
https://doaj.org/article/62c05122c5d4487ca6aeddd7a070957a
Publikováno v:
eLife, Vol 10 (2021)
MLL-rearranged leukemia depends on H3K79 methylation. Depletion of this transcriptionally activating mark by DOT1L deletion or high concentrations of the inhibitor pinometostat downregulates HOXA9 and MEIS1, and consequently reduces leukemia survival
Externí odkaz:
https://doaj.org/article/e5b40cfc226c4f88af0da6f8ae7c2097
Autor:
Rohan N Shah, Alexander J Ruthenburg
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 4, p e1008926 (2021)
Next-generation sequencing (NGS) has transformed molecular biology and contributed to many seminal insights into genomic regulation and function. Apart from whole-genome sequencing, an NGS workflow involves alignment of the sequencing reads to the ge
Externí odkaz:
https://doaj.org/article/18b352bcedc94f33b62bcc9cc323f2b2
Autor:
Xiangying Sun, Zhezhen Wang, Johnathon M Hall, Carlos Perez-Cervantes, Alexander J Ruthenburg, Ivan P Moskowitz, Michael Gribskov, Xinan H Yang
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1007119 (2020)
Long noncoding RNAs (lncRNAs) localize in the cell nucleus and influence gene expression through a variety of molecular mechanisms. Chromatin-enriched RNAs (cheRNAs) are a unique class of lncRNAs that are tightly bound to chromatin and putatively fun
Externí odkaz:
https://doaj.org/article/051a23354b0e48ffb502da9b4f7d411d
Autor:
Xinan H Yang, Rangarajan D Nadadur, Catharina RE Hilvering, Valerio Bianchi, Michael Werner, Stefan R Mazurek, Margaret Gadek, Kaitlyn M Shen, Joseph Aaron Goldman, Leonid Tyan, Jenna Bekeny, Johnathon M Hall, Nutishia Lee, Carlos Perez-Cervantes, Ozanna Burnicka-Turek, Kenneth D Poss, Christopher R Weber, Wouter de Laat, Alexander J Ruthenburg, Ivan P Moskowitz
Publikováno v:
eLife, Vol 6 (2017)
The noncoding genome is pervasively transcribed. Noncoding RNAs (ncRNAs) generated from enhancers have been proposed as a general facet of enhancer function and some have been shown to be required for enhancer activity. Here we examine the transcript
Externí odkaz:
https://doaj.org/article/483cf25f032e4eb3bd37b9b1b0cee643
Autor:
Mami Oikawa, Angela Simeone, Eva Hormanseder, Marta Teperek, Vincent Gaggioli, Alan O’Doherty, Emma Falk, Matthieu Sporniak, Clive D’Santos, Valar Nila Roamio Franklin, Kamal Kishore, Charles R. Bradshaw, Declan Keane, Thomas Freour, Laurent David, Adrian T. Grzybowski, Alexander J. Ruthenburg, John Gurdon, Jerome Jullien
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
In addition to paternal genetic material, sperm contributes epigenetic information to the embryo to efficiently support development. Here, the authors demonstrate a homogeneous paternal contribution to epigenetic information via sperm-derived modifie
Externí odkaz:
https://doaj.org/article/a043134247e74f1c9eff413a64d36d41
Autor:
William L. Stanford, Caryn Y. Ito, Mitchell Sabloff, Theodore J. Perkins, F. Jeffrey Dilworth, Alexander J. Ruthenburg, Elham Sabri, Adrian T. Grzybowski, Yuefeng Li, Joel P. Howard, Safwat T. Khan, Hannah L. Battaion, Julien Yockell-Lelièvre, Christopher J. Porter, Janet L. Manias Rothberg, Christopher Cafariello, Hani Jrade, Harinad B. Maganti
Supplementary figures and legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768a48405a5ec3f531527029e18918fb
https://doi.org/10.1158/2159-8290.22531762.v1
https://doi.org/10.1158/2159-8290.22531762.v1
Autor:
Jonathan D. Licht, Jan Liphardt, Alexander J. Ruthenburg, Neil L. Kelleher, George C. Schatz, Tanmay P. Lele, Alberto Riva, Qiao Zhang, Tao Yu, Adrian T. Grzybowski, Rajarshi P. Ghosh, Xiaoxiao Huang, Jon A. Oyer, Behnam Nabet, Christine M. Will, Eliza C. Small, Aditya Bele, Richard L. Bennett
List of all H4 missense mutations in cBioPortal nad dbSNP analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1ec1be9e4c0e0f409ee2926f26c2b4
https://doi.org/10.1158/2159-8290.22535885
https://doi.org/10.1158/2159-8290.22535885
Supplementary Table 2: H2B from A Mutation in Histone H2B Represents a New Class of Oncogenic Driver
Autor:
Jonathan D. Licht, Jan Liphardt, Alexander J. Ruthenburg, Neil L. Kelleher, George C. Schatz, Tanmay P. Lele, Alberto Riva, Qiao Zhang, Tao Yu, Adrian T. Grzybowski, Rajarshi P. Ghosh, Xiaoxiao Huang, Jon A. Oyer, Behnam Nabet, Christine M. Will, Eliza C. Small, Aditya Bele, Richard L. Bennett
List of all H2B missense mutations in cBioPortal and dbSNP analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42d432e63772deae6d95ad089c7c0b0
https://doi.org/10.1158/2159-8290.22535891
https://doi.org/10.1158/2159-8290.22535891
Autor:
Jonathan D. Licht, Jan Liphardt, Alexander J. Ruthenburg, Neil L. Kelleher, George C. Schatz, Tanmay P. Lele, Alberto Riva, Qiao Zhang, Tao Yu, Adrian T. Grzybowski, Rajarshi P. Ghosh, Xiaoxiao Huang, Jon A. Oyer, Behnam Nabet, Christine M. Will, Eliza C. Small, Aditya Bele, Richard L. Bennett
List of all H3 missense mutations in cBioPortal and dbSNP analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e967773c98ae5ef8365cd2bff0f4d38
https://doi.org/10.1158/2159-8290.22535888.v1
https://doi.org/10.1158/2159-8290.22535888.v1