Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexander J Glassford"'
Autor:
Ingo Kutschka, Ziad A. Ali, Philip S. Tsao, Stephen L. Hendry, Mary M. Chen, Patrick Yue, Diego Ardigò, Ramendera K. Kundu, Marc P. Pelletier, Hyung J. Chun, Robert C. Robbins, Andrew J. Connolly, Ahmad Y. Sheikh, Alexander J. Glassford, Thomas Quertermous, Roger A. Wagner, Diem T. Huynh
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 294:H88-H98
Signaling by the peptide ligand apelin and its cognate G protein-coupled receptor APJ has a potent inotropic effect on cardiac contractility and modulates systemic vascular resistance through nitric oxide-dependent signaling. In addition, there is ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9671a8fbeeadd8d965517a7e4546a4
https://doi.org/10.1152/ajpheart.00935.2007
https://doi.org/10.1152/ajpheart.00935.2007
Autor:
Thomas Quertermous, Gerald M. Reaven, Denise A. Chan, Alexander J. Glassford, Ahmad Y. Sheikh, Philip S. Tsao, Shirin Zarafshar, Patrick Yue, Hyung J. Chun
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 293:E1590-E1596
Apelin, a novel peptide with significant cardioactive properties, is upregulated by insulin in adipocytes. However, the mechanism by which insulin promotes apelin production is unknown. Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c128f2e739521b7938553a9ebe8daa28
https://doi.org/10.1152/ajpendo.00490.2007
https://doi.org/10.1152/ajpendo.00490.2007
Autor:
Philip S. Tsao, Hidetsugu Matsushita, Choy-Pik Chiu, Edwin Chang, Alexander J. Glassford, John P. Cooke
Publikováno v:
Circulation Research. 89:793-798
Advanced age is associated with endothelial dysfunction and increased risk for atherosclerosis. However, the mechanisms for these observed effects are not clear. To clarify the association between aging and loss of endothelial function, young human a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28df28ec7b35028312b88d9777fd0ae
https://doi.org/10.1161/hh2101.098443
https://doi.org/10.1161/hh2101.098443
Autor:
Shiro Uemura, David G. Harrison, Keun-Ho Lee, Hidetsugu Matsushita, Alexander J. Glassford, Tomoko Asagami, Philip S. Tsao, Wei Li
Publikováno v:
Circulation Research. 88:1291-1298
—Diabetes mellitus (DM) is a primary risk factor for cardiovascular disease. Although recent studies have demonstrated an important role for extracellular matrix metalloproteinases (MMPs) in atherosclerosis, little is known about the effects of hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4361f107a3cb2381afeef489da6507cb
https://doi.org/10.1161/hh1201.092042
https://doi.org/10.1161/hh1201.092042
Autor:
Timothy C. Doyle, J. Hoffmann, Robert C. Robbins, Alexander J. Glassford, Sonja Schrepfer, Marc P. Pelletier
Publikováno v:
The Thoracic and cardiovascular surgeon. 58(3)
Bone marrow-derived mesenchymal stem cells (MSCs) are multipotent and secrete angiogenic factors, which could help patients with occlusive arterial diseases. We hypothesize that MSCs, in comparison to fibroblasts, survive better under hypoxic conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad6bb985b736c710f0be6f307844370
https://pubmed.ncbi.nlm.nih.gov/20379963
https://pubmed.ncbi.nlm.nih.gov/20379963
Autor:
Patrick Yue, Tomoko Asagami, Ramendra K Kundu, Yin-Gail Yee, Alexander J Glassford, Junya Azuma, Thomas Quertermous, Philip S Tsao
Publikováno v:
Circulation. 116
Background : Apelin, a peptide hormone with unique cardioactive properties, is also an adipokine, secreted by adipocytes in response to insulin. However, the overall effect of apelin on insulin sensitivity remains largely uncharacterized. Methods : F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::768797b24e3cf892c3ddb19bb7a71848
https://doi.org/10.1161/circ.116.suppl_16.ii_247
https://doi.org/10.1161/circ.116.suppl_16.ii_247
Autor:
Santosh S. Oommen, Akhilesh K. Sista, Alexander J. Glassford, Philip S. Tsao, Charles A. Taylor, Gerald M. Reaven, Mary K. O'Connell, Brett E. Fenster, Tomoya T. Hinohara, Eric A. Schwartz
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 289(2)
Accumulating clinical evidence indicates increased aortic stiffness, an independent risk factor for cardiovascular and all-cause mortality, in type 2 diabetic and glucose-intolerant individuals. The present study sought to determine whether increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2940e7f289f323a8ef1ef54781a9e7
https://pubmed.ncbi.nlm.nih.gov/15833807
https://pubmed.ncbi.nlm.nih.gov/15833807
Publikováno v:
Neurological research. 24(8)
Excitotoxicity has been demonstrated to play a major role in ischemic neuronal injury. While the necrotic component of excitotoxicity has been well demonstrated, apoptosis has also been shown to play a role. We sought to quantitate and modulate the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50d4238fd908fcf6521fae3a683f110
https://pubmed.ncbi.nlm.nih.gov/12500703
https://pubmed.ncbi.nlm.nih.gov/12500703
Publikováno v:
Neuroreport. 9(5)
ACIDOSIS is a well established concomitant of tissue ischemia. Acidosis in the pH range 6.0-7.0 is seen in cerebral ischemia and within solid tumors. Extracellular acidosis of pH 6.0 and 6.4 provided essentially complete protection from 48 h serum de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d70637789c4031c41f11467b2ba43e
https://pubmed.ncbi.nlm.nih.gov/9579683
https://pubmed.ncbi.nlm.nih.gov/9579683