Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alexander J, Cammack"'
Autor:
Robi D. Mitra, Katherine B. McCullough, Susan E. Maloney, June He, Allen Yen, Mark Shabsovich, Joseph D. Dougherty, Michael J. Vasek, Arnav Moudgil, Jiayang Chen, Tomas Lagunas, Timothy M. Miller, Alexander J. Cammack, Michael N. Wilkinson, Misha Hooda, Xuhua Chen
Publikováno v:
Proc Natl Acad Sci U S A
Transcription factors (TFs) enact precise regulation of gene expression through site-specific, genome-wide binding. Common methods for TF-occupancy profiling, such as chromatin immunoprecipitation, are limited by requirement of TF-specific antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d42bde89ba22c5e1c3db12776c8faa8
https://doi.org/10.1073/pnas.1918241117
https://doi.org/10.1073/pnas.1918241117
Autor:
Mimi C Sammarco, Jennifer Simkin, Alexander J Cammack, Danielle Fassler, Alexej Gossmann, Luis Marrero, Michelle Lacey, Keith Van Meter, Ken Muneoka
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140156 (2015)
Oxygen is critical for optimal bone regeneration. While axolotls and salamanders have retained the ability to regenerate whole limbs, mammalian regeneration is restricted to the distal tip of the digit (P3) in mice, primates, and humans. Our previous
Externí odkaz:
https://doaj.org/article/ee60b869acaa45529983dd55a8a83cac
Autor:
Sonia Boodram, Amber Salter, Robert H. Baloh, Diane McKenna-Yasek, Matthew B. Harms, Thomas J. Esparza, Theodore Hyman, Robert H. Brown, Caroline Drain, Nicholas Wightman, Carlos Cruchaga, Alzheimer’s Disease Neuroimaging Initiative, Leonard H. van den Berg, Toby A. Ferguson, Jan H. Veldink, Alexander Sherman, Michael A. van Es, Hong Yu, Catherine Douthwright, Jennifer Jockel-Balsarotti, Merit Cudkowicz, Alexander McCampbell, Margaret A. Owegi, Timothy M. Miller, Nazem Atassi, Amber Malcolm, Alexander J. Cammack, Bálint S de Vries, Jeffrey D. Rothstein
Publikováno v:
Neurology. 93:e1605-e1617
ObjectiveTo define the natural history of the C9orf72 amyotrophic lateral sclerosis (C9ALS) patient population, develop disease biomarkers, and characterize patient pathologies.MethodsWe prospectively collected clinical and demographic data from 116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddc96232b3c87150081db892edd8e7c7
https://doi.org/10.1212/wnl.0000000000008359
https://doi.org/10.1212/wnl.0000000000008359
Autor:
Chun Guo, Collin J. Nadarajah, Brian V. Lananna, Jinsong Zhang, Jorge L. Del-Aguila, Jack A. Elias, Erik S. Musiek, Celia A. McKee, Carlos Cruchaga, David D. Xiong, Melvin W. King, Alexander J. Cammack, Julie Dimitry, Fabiana H.G. Farias
Publikováno v:
Sci Transl Med
Regulation of glial activation and neuroinflammation are critical factors in the pathogenesis of Alzheimer's disease (AD). YKL-40, a primarily astrocytic protein encoded by the gene Chi3l1, is a widely studied cerebrospinal fluid biomarker that incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27a0dd693d16dd5f07fe6eb0a705dbb
https://doi.org/10.1126/scitranslmed.aax3519
https://doi.org/10.1126/scitranslmed.aax3519
Autor:
June He, Zongtai Qi, Samantha A. Morris, Robi D. Mitra, Michael N. Wilkinson, Michael J. Vasek, Alexander J. Cammack, Joseph D. Dougherty, Xuhua Chen, Arnav Moudgil, Tomas Lagunas
In situ measurements of transcription factor (TF) binding are confounded by cellular heterogeneity and represent averaged profiles in complex tissues. Single cell RNA-seq (scRNA-seq) is capable of resolving different cell types based on gene expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad4d5f1b4537287beb2f94cdb9f1420
Autor:
Mark Shabsovich, Xuhua Chen, Michael N. Wilkinson, Arnav Moudgil, Joseph D. Dougherty, Jiayang Chen, Michael J. Vasek, Misha Hooda, Katherine B. McCullough, Robi D. Mitra, Alexander J. Cammack, June He, Tomas Lagunas, Timothy M. Miller
Transcription factors (TFs) play a central role in the regulation of gene expression, controlling everything from cell fate decisions to activity dependent gene expression. However, widely-used methods for TF profiling in vivo (e.g. ChIP-seq) yield o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff0f4786e58fd6d2f4222c06a0e6cb5
Autor:
Timothy M. Miller, Takuya Yagi, Jana Mahadevan, Alexander J. Cammack, Fumihiko Urano, Matthew B. Harms, Kohsuke Kanekura, Masahiko Kuroda
Publikováno v:
Human Molecular Genetics. 25:1803-1813
The expansion of the GGGGCC hexanucleotide repeat in the non-coding region of the Chromosome 9 open-reading frame 72 (C9orf72) gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). This geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a588dc5c6c28fe616b122d0b759d41
https://doi.org/10.1093/hmg/ddw052
https://doi.org/10.1093/hmg/ddw052
Autor:
Xuhua Chen, June He, Arnav Moudgil, Tomas Lagunas, Alexander J. Cammack, Michael N. Wilkinson, Michael J. Vasek, Samantha A. Morris, Zongtai Qi, Chuner Guo, Joseph D. Dougherty, Matthew A. Lalli, Robi D. Mitra
Publikováno v:
Cell
Cellular heterogeneity confounds in situ assays of transcription factor (TF) binding. Single-cell RNA sequencing (scRNA-seq) deconvolves cell types from gene expression, but no technology links cell identity to TF binding sites (TFBS) in those cell t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddcc8651d4a15a4cf41033c5e19fa21
https://doi.org/10.1016/j.cell.2020.06.037
https://doi.org/10.1016/j.cell.2020.06.037
Autor:
Alexander J, Cammack, Nazem, Atassi, Theodore, Hyman, Leonard H, van den Berg, Matthew, Harms, Robert H, Baloh, Robert H, Brown, Michael A, van Es, Jan H, Veldink, Balint S, de Vries, Jeffrey D, Rothstein, Caroline, Drain, Jennifer, Jockel-Balsarotti, Amber, Malcolm, Sonia, Boodram, Amber, Salter, Nicholas, Wightman, Hong, Yu, Alexander V, Sherman, Thomas J, Esparza, Diane, McKenna-Yasek, Margaret A, Owegi, Catherine, Douthwright, Alexander, McCampbell, Toby, Ferguson, Carlos, Cruchaga, Merit, Cudkowicz, Timothy M, Miller
Publikováno v:
Neurology
OBJECTIVE: To define the natural history of the C9orf72 amyotrophic lateral sclerosis (C9ALS) patient population, develop disease biomarkers, and characterize patient pathologies. METHODS: We prospectively collected clinical and demographic data from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b46b32177bb46a54b63a1cc415d8531
https://pubmed.ncbi.nlm.nih.gov/31578300
https://pubmed.ncbi.nlm.nih.gov/31578300
Autor:
Catherine Tucker, Ken Muneoka, Alexander J. Cammack, Luis Marrero, Lindsay A. Dawson, Mingquan Yan, Jennifer Simkin, Mimi C. Sammarco
Publikováno v:
Development (Cambridge, England). 144(21)
In mammals, macrophages are known to play a major role in tissue regeneration. These cells contribute to inflammation, histolysis, re-epithelialization, re-vascularization and cell proliferation. While macrophages have been shown to be essential for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26eb0b6b0603b3a190151e62c5574fe
https://pubmed.ncbi.nlm.nih.gov/28935712
https://pubmed.ncbi.nlm.nih.gov/28935712