Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alexander I. Wallick"'
Autor:
Swagat Sharma, Qi Peng, Anish K. Vadukoot, Christopher D. Aretz, Aaron A. Jensen, Alexander I. Wallick, Xinzhong Dong, Corey R. Hopkins
Publikováno v:
ACS Med Chem Lett
[Image: see text] The present study describes our continued efforts in the discovery and characterization of a series of 2-sulfonamidebenzamides as allosteric modulators of MrgX1. MrgX1 has been shown to be an attractive target as a nonopioid recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41db227b3095c3d83563ef62827730c
https://pubmed.ncbi.nlm.nih.gov/35586421
https://pubmed.ncbi.nlm.nih.gov/35586421
Autor:
Paul H. Davis, Yan Liu, Matthew C Martens, Rongshi Li, Rosalie C Warner, Alexander I Wallick, Austin G. Sanford
Publikováno v:
Antimicrob Agents Chemother
The apicomplexan parasite Toxoplasma gondii is the causative agent of toxoplasmosis, a globally distributed infection with severe clinical consequences for immunocompromised individuals and developing fetuses. There are few available treatments, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07750d8f201bfe9b304e5f6758ba3a4d
https://europepmc.org/articles/PMC8765230/
https://europepmc.org/articles/PMC8765230/
Autor:
Francis C. K. Chiu, David M. Shackleford, Jianbo Wu, Karen L. White, Paul H. Davis, Alexander I. Wallick, Yuxiang Dong, Eileen Ryan, Jonathan L. Vennerstrom, Sriraghavan Kamaraj, Cécile Häberli, Susan A. Charman, Jennifer Keiser, Vivek J. Bulbule, Xiaofang Wang
Publikováno v:
J Med Chem
Semisynthetic artemisinins and other bioactive peroxides are best known for their powerful antimalarial activities, and they also show substantial activity against schistosomes-another hemoglobin-degrading pathogen. Building on this discovery, we now
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e45a723a4bfa09fada381455c6650b9
https://europepmc.org/articles/PMC7182039/
https://europepmc.org/articles/PMC7182039/
Autor:
Rosalie C. Warner, Katie Higgins, Monica Cal, Bret Belter, Samuel Anderson, Tasloach Wol, Derek A. Leas, Victoria Mashinson, Grant Darner, Carlos Vera-Esquivel, Alexander I. Wallick, James P. Hagen, Paul H. Davis, Marcel Kaiser, Ananya Mitra
Publikováno v:
Bioorganic Chemistry. 97:103590
Insect-borne parasite Trypanosoma brucei plagues humans and other animals, eliciting the disease Human African trypanosomiasis, also known as African sleeping sickness. This disease poses the biggest threat to the people in Sub-Saharan Africa. Given
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af506b32aa38823678dd735d67e852e
https://doi.org/10.1016/j.bioorg.2020.103590
https://doi.org/10.1016/j.bioorg.2020.103590
Autor:
Frederick S. Buckner, Austin G. Sanford, Paul H. Davis, Monica Cal, Galina I. Lepesheva, Alexander I. Wallick, Xiaofang Wang, Jonathan L. Vennerstrom, Marcel Kaiser
Publikováno v:
Bioorg Med Chem Lett
Pyridyl benzamide 2 is a potent inhibitor of Trypanosoma cruzi, but not other protozoan parasites, and had a selectivity-index of ≥10. The initial structure-activity relationship (SAR) indicates that benzamide and sulfonamide functional groups, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd344dc95014fbac496165043fce24b
https://doi.org/10.1016/j.bmcl.2019.126778
https://doi.org/10.1016/j.bmcl.2019.126778