Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alexander Hruscha"'
Autor:
Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K. Schmidt, Brigitte Nuscher, Martin Giera, Sarantos Kostidis, Özge Burhan, Frauke van Bebber, Dieter Edbauer, Thomas Arzberger, Christian Haass, Bettina Schmid
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-23 (2024)
Abstract Background The key pathological signature of ALS/ FTLD is the mis-localization of endogenous TDP-43 from the nucleus to the cytoplasm. However, TDP-43 gain of function in the cytoplasm is still poorly understood since TDP-43 animal models re
Externí odkaz:
https://doaj.org/article/3a903ab063944d74afd22278e76a4d88
Autor:
Anna Nieborak, Saulius Lukauskas, Jordi Capellades, Patricia Heyn, Gabriela Silva Santos, Karsten Motzler, Anja Zeigerer, Romina Bester, Ulrike Protzer, Florian Schelter, Mirko Wagner, Thomas Carell, Alexander Hruscha, Bettina Schmid, Oscar Yanes, Robert Schneider
Publikováno v:
Molecular Metabolism, Vol 74, Iss , Pp 101748- (2023)
Objective: Cancer cells convert more glucose into lactate than healthy cells, what contributes to their growth advantage. Pyruvate kinase (PK) is a key rate limiting enzyme in this process, what makes it a promising potential therapeutic target. Howe
Externí odkaz:
https://doaj.org/article/1cdb8cc6c3104464995700a9b14eb2eb
Autor:
Katrin Hipke, Bettina Pitter, Alexander Hruscha, Frauke van Bebber, Miha Modic, Vikas Bansal, Sebastian A. Lewandowski, Denise Orozco, Dieter Edbauer, Stefan Bonn, Christian Haass, Ulrich Pohl, Eloi Montanez, Bettina Schmid
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Aggregation of the Tar DNA-binding protein of 43 kDa (TDP-43) is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia and likely contributes to disease by loss of nuclear function. Analysis of TDP-43 function in knocko
Externí odkaz:
https://doaj.org/article/41783c87576d4c5381ad20b7824e8c6c
Publikováno v:
Neurobiology of Disease, Vol 39, Iss 3, Pp 265-271 (2010)
Methylene blue is an FDA approved compound with a variety of pharmacologic activities. It inhibits aggregation of several amyloidogenic proteins known to be deposited in neurodegenerative diseases. Recently, it has been proposed that methylene blue s
Externí odkaz:
https://doaj.org/article/58c22d3fa5134bc0ac235044784489c3
Autor:
Kazuhide Asakawa, Dieter Edbauer, Christian Haass, Andrea Wenninger-Weinzierl, Yu Ohki, Bettina Schmid, Alexander Hruscha, Koichi Kawakami
Publikováno v:
Molecular Neurodegeneration
Molecular neurodegeneration 12(1), 6 (2017). doi:10.1186/s13024-016-0146-8
Molecular neurodegeneration 12(1), 6 (2017). doi:10.1186/s13024-016-0146-8
Background The most frequent genetic cause of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) is the expansion of a GGGGCC hexanucleotide repeat in a non-coding region of the chromosome 9 open reading frame 72 (C9orf7
Autor:
Bettina Schmid, Alexander Hruscha, Thomas Misgeld, Christian Haass, Gabriela Plucińska, Dominik Paquet, Leanne Godinho
Publikováno v:
Journal of Neuroscience; Vol 32
The journal of neuroscience 32(46), 16203-16212 (2012). doi:10.1523/JNEUROSCI.1327-12.2012
The journal of neuroscience 32(46), 16203-16212 (2012). doi:10.1523/JNEUROSCI.1327-12.2012
Mitochondria provide ATP, maintain calcium homeostasis, and regulate apoptosis. Neurons, due to their size and complex geometry, are particularly dependent on the proper functioning and distribution of mitochondria. Thus disruptions of these organell
Publikováno v:
Neurobiology of Disease; Vol 39
Neurobiology of disease 39(3), 265-271 (2010). doi:10.1016/j.nbd.2010.03.023
Neurobiology of Disease, Vol 39, Iss 3, Pp 265-271 (2010)
Neurobiology of disease 39(3), 265-271 (2010). doi:10.1016/j.nbd.2010.03.023
Neurobiology of Disease, Vol 39, Iss 3, Pp 265-271 (2010)
Methylene blue is an FDA approved compound with a variety of pharmacologic activities. It inhibits aggregation of several amyloidogenic proteins known to be deposited in neurodegenerative diseases. Recently, it has been proposed that methylene blue s
Autor:
Alexander, Hruscha, Bettina, Schmid
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1254
The CRISPR /Cas system identified in archaea has been adopted and optimized for genome editing purposes in zebrafish. In vitro transcribed guide RNA and Cas9 mRNA are microinjected into fertilized zebrafish embryos to edit the zebrafish genome. Here,
Autor:
Bettina Schmid, Alexander Hruscha
Publikováno v:
Methods in Molecular Biology ISBN: 9781493921515
The CRISPR /Cas system identified in archaea has been adopted and optimized for genome editing purposes in zebrafish. In vitro transcribed guide RNA and Cas9 mRNA are microinjected into fertilized zebrafish embryos to edit the zebrafish genome. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd1fa213bad8bfb045946eceb72c98da
https://doi.org/10.1007/978-1-4939-2152-2_24
https://doi.org/10.1007/978-1-4939-2152-2_24
Autor:
Alexandra Rechenberg, Peter Krawitz, Jochen Hecht, Alexander Hruscha, Verena Heinrich, Christian Haass, Bettina Schmid
Publikováno v:
Development 140(24), 4982-4987 (2013). doi:10.1242/dev.099085
Gene modifications in animal models have been greatly facilitated through the application of targeted genome editing tools. The prokaryotic CRISPR/Cas9 type II genome editing system has recently been applied in cell lines and vertebrates. However, we