Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Alexander Heinick"'
Autor:
Julius R. Herting, Jule H. König, Katarina Hadova, Alexander Heinick, Frank U. Müller, Paul Pauls, Matthias D. Seidl, Carolina Soppa, Uwe Kirchhefer
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundThe activity, localization, and substrate specificity of the protein phosphatase 2A (PP2A) heterotrimer are controlled by various regulatory B subunits. PR72 belongs to the B'' gene family and has been shown to be upregulated in human heart
Externí odkaz:
https://doaj.org/article/0391b36d90b2486bb1c37216f3917b3b
Autor:
Julius R. Herting, Anna M. Berg, Katarina Hadova, Alexander Heinick, Simone König, Michael Kuhlmann, Frank U. Müller, Uwe Kirchhefer
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 3, Iss , Pp 100030- (2023)
Protein phosphatase 2A (PP2A) plays a central role in myocardial ischemia-reperfusion (I/R) injury. Several studies showed a detrimental function of PP2A by using either overexpression models of the catalytic subunit (PP2Ac) or exogenous inhibitors o
Externí odkaz:
https://doaj.org/article/5d5599b4e278488591046593677070c4
Autor:
Florentina Pluteanu, Peter Boknik, Alexander Heinick, Christiane König, Frank U. Müller, Adam Weidlich, Uwe Kirchhefer
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 322:H427-H441
The importance of the serine-41 phosphorylation site on B56α in reducing PP2A activity was demonstrated for the first time using a transgenic mutation model. The direct activation of PKC inhibits PP2A, leading to increased phosphorylation of MyBP-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1672412db3bd19a361c4622fdb4bfe43
https://doi.org/10.1152/ajpheart.00539.2021
https://doi.org/10.1152/ajpheart.00539.2021
Autor:
Dennis, Glaser, Alexander, Heinick, Julius R, Herting, Fabian, Massing, Frank U, Müller, Paul, Pauls, Timofey S, Rozhdestvensky, Jan S, Schulte, Matthias D, Seidl, Boris V, Skryabin, Frank, Stümpel, Uwe, Kirchhefer
Publikováno v:
The Journal of biological chemistry. 298(9)
The activity of protein phosphatase 2A (PP2A) is determined by the expression and localization of the regulatory B-subunits. PP2A-B56α is the dominant isoform of the B'-family in the heart. Its role in regulating the cardiac response to β-adrenergi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::436e762de8cbe31141e113f5e6703535
https://pubmed.ncbi.nlm.nih.gov/35963431
https://pubmed.ncbi.nlm.nih.gov/35963431
Autor:
Wilhelm Schmitz, Christina Hermes, Andre Klemme, Alexander Heinick, Manuel Domnik, Frank U. Müller, Xenia Husser, Florentina Pluteanu, Volker Gerke
Publikováno v:
The FASEB Journal. 34:10489-10504
Adenylyl cyclases (AC) are essential for the normal and pathophysiological response of many cells. In cardiomyocytes, the predominant AC isoforms are AC5 and AC6. Specific AC5 inhibition was suggested as an option for the treatment of heart failure p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8086d34fcac8f29250d6a6c3659e774f
https://doi.org/10.1096/fj.201902094rr
https://doi.org/10.1096/fj.201902094rr
Autor:
Dennis Glaser, Alexander Heinick, Julius R. Herting, Fabian Massing, Frank U. Müller, Paul Pauls, Timofey S. Rozhdestvensky, Jan S. Schulte, Matthias D. Seidl, Boris V. Skryabin, Frank Stümpel, Uwe Kirchhefer
Publikováno v:
Journal of Biological Chemistry. 298:102362
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2d0055d5b239db753347905a88d6f0a
https://doi.org/10.1016/j.jbc.2022.102362
https://doi.org/10.1016/j.jbc.2022.102362
Autor:
Gunnar Isensee, Alexander Heinick, Joachim Neumann, Jan S. Schulte, Peter Boknik, Frank U. Müller, Kirsten Schulte, Matthias D. Seidl, Elke Hammer, Thomas Herpertz, Uwe Kirchhefer
Publikováno v:
Journal of Molecular and Cellular Cardiology. 125:195-204
Rationale A higher expression/activity of type 1 serine/threonine protein phosphatase 1 (PP1) may contribute to dephosphorylation of cardiac regulatory proteins triggering the development of heart failure. Objective Here, we tested the putatively pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307989027d05f55dbd839608abdb7f95
https://doi.org/10.1016/j.yjmcc.2018.10.022
https://doi.org/10.1016/j.yjmcc.2018.10.022
Autor:
Uwe Kirchhefer, Gunnar Isensee, Peter Boknik, Kirsten Schulte, Matthias D. Seidl, Jan S. Schulte, Elke Hammer, Thomas Herpertz, Frank U. Müller, Joachim Neumann, Alexander Heinick
Publikováno v:
Journal of Molecular and Cellular Cardiology. 143:160
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dedfdf0046d7777506dc78a660cb963
https://doi.org/10.1016/j.yjmcc.2019.10.007
https://doi.org/10.1016/j.yjmcc.2019.10.007
Autor:
Jan S. Schulte, Hans R. Schöler, Alexander Heinick, Ilaria Piccini, Kee-Pyo Kim, Miao Zhang, Daniela Malan, Philipp Sasse, Boris Greber, Dagmar Zeuschner, Paulus Kirchhof, Larissa Fabritz, Guiscard Seebohm, Marcos J. Araúzo-Bravo, Jyoti Rao, Frank U. Müller, Albrecht Röpke, Roberto Quaranta
Publikováno v:
Stem Cells. 33:1456-1469
Directed cardiac differentiation of human pluripotent stem cells (hPSCs) enables disease modeling, investigation of human cardiogenesis, as well as large-scale production of cardiomyocytes (CMs) for translational purposes. Multiple CM differentiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b418d5509d73c49b6fdb53dd9b18d87
https://doi.org/10.1002/stem.1964
https://doi.org/10.1002/stem.1964
Autor:
Markus Böhm, Bernd L. Fiebich, Sergei A. Grando, Jan S. Schulte, Thomas A. Luger, Agatha Stegemann, Adriana del Rey, Anca Sindrilaru, Beate Eckes, Frank U. Müller, Karin Scharffetter-Kochanek, Alexander Heinick
Publikováno v:
Arthritis & Rheumatism. 65:792-804
Objective There is increasing evidence that serotonin (5-hydroxytryptamine [5-HT]) and distinct 5-HT receptors are involved in the pathogenesis of systemic sclerosis. The aim of this study was to test the hypothesis that tropisetron, a routinely used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15dbca2927a96a421b5dc148a9497b19
https://doi.org/10.1002/art.37809
https://doi.org/10.1002/art.37809