Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Alexander Hawlitschka"'
Autor:
Teresa Alberts, Veronica Antipova, Carsten Holzmann, Alexander Hawlitschka, Oliver Schmitt, Jens Kurth, Jan Stenzel, Tobias Lindner, Bernd J. Krause, Andreas Wree, Martin Witt
Publikováno v:
Toxins, Vol 14, Iss 2, p 94 (2022)
Olfactory deficits occur as early non-motor symptoms of idiopathic Parkinson’s disease (PD) in humans. The first central relay of the olfactory pathway, the olfactory bulb (OB), depends, among other things, on an intact, functional crosstalk betwee
Externí odkaz:
https://doaj.org/article/6f9667f8c4da4e5ebae7c0796549d0f8
Publikováno v:
Toxins, Vol 13, Iss 7, p 505 (2021)
Parkinson’s patients often suffer from depression and anxiety, for which there are no optimal treatments. Hemiparkinsonian (hemi-PD) rats were used to test whether intrastriatal Botulinum neurotoxin-A (BoNT-A) application could also have antidepres
Externí odkaz:
https://doaj.org/article/ecb08e5c21b5441dbc5fb871193cf231
Autor:
Teresa Mann, Karl Zilles, Felix Klawitter, Markus Cremer, Alexander Hawlitschka, Nicola Palomero-Gallagher, Oliver Schmitt, Andreas Wree
Publikováno v:
Frontiers in Neuroanatomy, Vol 12 (2018)
Cholinergic neurotransmission has a pivotal function in the caudate-putamen, and is highly associated with the pathophysiology of Parkinson's disease. Here, we investigated long-term changes in the densities of the muscarinic receptor subtypes M1, M2
Externí odkaz:
https://doaj.org/article/fd0b51a3c8134456a8391560cbcec44d
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 11 (2017)
Parkinson’s disease (PD) is one of the most frequent neurodegenerative disorders. The loss of dopaminergic neurons in the substantia nigra leads to a disinhibition of cholinergic interneurons in the striatum. Pharmacotherapeutical strategies of PD-
Externí odkaz:
https://doaj.org/article/7c0c988a303247a4895a043b917c29d4
Autor:
Andreas Wree, Eilhard Mix, Alexander Hawlitschka, Veronica Antipova, Martin Witt, Oliver Schmitt, Reiner Benecke
Publikováno v:
Neurobiology of Disease, Vol 41, Iss 2, Pp 291-298 (2011)
Central pathophysiological pathways of basal ganglia dysfunction imply a disturbed interaction of dopaminergic and cholinergic circuits. In Parkinson's disease (PD) imbalanced cholinergic hyperactivity prevails in the striatum. Interruption of acetyl
Externí odkaz:
https://doaj.org/article/28ed22390c56416eabc4625b9a9b4966
Publikováno v:
Toxins, Vol 10, Iss 9, p 368 (2018)
Injection of botulinum neurotoxin-A (BoNT-A) into the striatum of hemiparkinsonian (hemi-PD) rats reduced apomorphine-induced rotation behavior significantly, for at least 3 months. Thereafter, rotation behavior increased again. We injected hemi-PD r
Externí odkaz:
https://doaj.org/article/286d9c8020ea49aa85f44a1a3c18c54b
Autor:
Veronica Antipova, Andreas Wree, Carsten Holzmann, Teresa Mann, Nicola Palomero-Gallagher, Karl Zilles, Oliver Schmitt, Alexander Hawlitschka
Publikováno v:
Toxins, Vol 10, Iss 7, p 295 (2018)
Different morphological changes in the caudate-putamen (CPu) of naïve rats and mice were observed after intrastriatal botulinum neurotoxin-A (BoNT-A) injection. For this purpose we here studied various motor behaviors in mice (n = 46) longitudinally
Externí odkaz:
https://doaj.org/article/f45b555c5e084fb1adad96f1ee328b5a
Autor:
Teresa Mann, Jens Kurth, Alexander Hawlitschka, Jan Stenzel, Tobias Lindner, Stefan Polei, Alexander Hohn, Bernd J. Krause, Andreas Wree
Publikováno v:
Molecules, Vol 23, Iss 3, p 587 (2018)
Intrastriatal injection of botulinum neurotoxin A (BoNT-A) results in improved motor behavior of hemiparkinsonian (hemi-PD) rats, an animal model for Parkinson’s disease. The caudate–putamen (CPu), as the main input nucleus of the basal ganglia l
Externí odkaz:
https://doaj.org/article/bd654c025e1a47128f0203fa80ba22c8
Publikováno v:
Bildverarbeitung in der Automation ISBN: 9783662667682
Research of image recognition allows for improvements in animal welfare compliant and increase in data yield in animal experiments. One application for improvements are the so-called rotational tests with rats in Parkinson research. Here, the Rat Rot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7791cf446176b2ee23a46bf2e660522b
https://doi.org/10.1007/978-3-662-66769-9_5
https://doi.org/10.1007/978-3-662-66769-9_5
Autor:
Elise Vankriekelsvenne, Uta Chrzanowski, Katerina Manzhula, Theresa Greiner, Andreas Wree, Alexander Hawlitschka, Gemma Llovera, Jiangshan Zhan, Sarah Joost, Christoph Schmitz, Peter Ponsaerts, Sandra Amor, Erik Nutma, Markus Kipp, Hannes Kaddatz
Publikováno v:
GLIA, 70(6), 1170-1190. John Wiley and Sons Inc.
Vankriekelsvenne, E, Chrzanowski, U, Manzhula, K, Greiner, T, Wree, A, Hawlitschka, A, Llovera, G, Zhan, J, Joost, S, Schmitz, C, Ponsaerts, P, Amor, S, Nutma, E, Kipp, M & Kaddatz, H 2022, ' Transmembrane protein 119 is neither a specific nor a reliable marker for microglia ', GLIA, vol. 70, no. 6, pp. 1170-1190 . https://doi.org/10.1002/glia.24164
Glia
Vankriekelsvenne, E, Chrzanowski, U, Manzhula, K, Greiner, T, Wree, A, Hawlitschka, A, Llovera, G, Zhan, J, Joost, S, Schmitz, C, Ponsaerts, P, Amor, S, Nutma, E, Kipp, M & Kaddatz, H 2022, ' Transmembrane protein 119 is neither a specific nor a reliable marker for microglia ', GLIA, vol. 70, no. 6, pp. 1170-1190 . https://doi.org/10.1002/glia.24164
Glia
Microglia are the resident innate immune cells of the central nervous system (CNS) parenchyma. To determine the impact of microglia on disease development and progression in neurodegenerative and neuroinflammatory diseases, it is essential to disting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e3ceb3c00e4382794b6ecab59cb511
https://research.vumc.nl/en/publications/6f9c9614-a5c4-4a4d-919d-2c93e46df8c9
https://research.vumc.nl/en/publications/6f9c9614-a5c4-4a4d-919d-2c93e46df8c9