Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Alexander Hawlitschka"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1685 (2023)
In Parkinson’s disease, hypercholinism in the striatum occurs, with the consequence of disturbed motor functions. Direct application of Botulinum neurotoxin-A in the striatum of hemi-Parkinsonian rats might be a promising anticholinergic therapeuti
Externí odkaz:
https://doaj.org/article/80f3897649ca40bcbfb96d104e83d7f7
Autor:
Theo Gabloffsky, Sadaf Gill, Anna Staffeld, Ralf Salomon, Nicole Power Guerra, Sarah Joost, Alexander Hawlitschka, Markus Kipp, Linda Frintrop
Publikováno v:
Nutrients, Vol 14, Iss 24, p 5252 (2022)
Anorexia nervosa (AN) is characterized by emaciation, hyperactivity, and amenorrhea. To what extent AN-related symptoms are due to food restriction or neuronal dysfunction is currently unknown. Thus, we investigated the relevance of food restriction
Externí odkaz:
https://doaj.org/article/7183d2c194284ff89064178457e48dbd
Autor:
Teresa Alberts, Veronica Antipova, Carsten Holzmann, Alexander Hawlitschka, Oliver Schmitt, Jens Kurth, Jan Stenzel, Tobias Lindner, Bernd J. Krause, Andreas Wree, Martin Witt
Publikováno v:
Toxins, Vol 14, Iss 2, p 94 (2022)
Olfactory deficits occur as early non-motor symptoms of idiopathic Parkinson’s disease (PD) in humans. The first central relay of the olfactory pathway, the olfactory bulb (OB), depends, among other things, on an intact, functional crosstalk betwee
Externí odkaz:
https://doaj.org/article/6f9667f8c4da4e5ebae7c0796549d0f8
Publikováno v:
Toxins, Vol 13, Iss 7, p 505 (2021)
Parkinson’s patients often suffer from depression and anxiety, for which there are no optimal treatments. Hemiparkinsonian (hemi-PD) rats were used to test whether intrastriatal Botulinum neurotoxin-A (BoNT-A) application could also have antidepres
Externí odkaz:
https://doaj.org/article/ecb08e5c21b5441dbc5fb871193cf231
Autor:
Teresa Mann, Karl Zilles, Felix Klawitter, Markus Cremer, Alexander Hawlitschka, Nicola Palomero-Gallagher, Oliver Schmitt, Andreas Wree
Publikováno v:
Frontiers in Neuroanatomy, Vol 12 (2018)
Cholinergic neurotransmission has a pivotal function in the caudate-putamen, and is highly associated with the pathophysiology of Parkinson's disease. Here, we investigated long-term changes in the densities of the muscarinic receptor subtypes M1, M2
Externí odkaz:
https://doaj.org/article/fd0b51a3c8134456a8391560cbcec44d
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 11 (2017)
Parkinson’s disease (PD) is one of the most frequent neurodegenerative disorders. The loss of dopaminergic neurons in the substantia nigra leads to a disinhibition of cholinergic interneurons in the striatum. Pharmacotherapeutical strategies of PD-
Externí odkaz:
https://doaj.org/article/7c0c988a303247a4895a043b917c29d4
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 4, p 992 (2019)
Forelimb stepping is a widely used test for the assessment of forelimb akinesia in hemiparkinsonian (hemi-PD) rats. The initiation time (IT) is considered the most sensitive parameter in the stepping test procedure. Here we propose a novel, reliable,
Externí odkaz:
https://doaj.org/article/0c18aa3cb09445c39a11f733b29ebad9
Autor:
Andreas Wree, Eilhard Mix, Alexander Hawlitschka, Veronica Antipova, Martin Witt, Oliver Schmitt, Reiner Benecke
Publikováno v:
Neurobiology of Disease, Vol 41, Iss 2, Pp 291-298 (2011)
Central pathophysiological pathways of basal ganglia dysfunction imply a disturbed interaction of dopaminergic and cholinergic circuits. In Parkinson's disease (PD) imbalanced cholinergic hyperactivity prevails in the striatum. Interruption of acetyl
Externí odkaz:
https://doaj.org/article/28ed22390c56416eabc4625b9a9b4966
Publikováno v:
Toxins, Vol 10, Iss 9, p 368 (2018)
Injection of botulinum neurotoxin-A (BoNT-A) into the striatum of hemiparkinsonian (hemi-PD) rats reduced apomorphine-induced rotation behavior significantly, for at least 3 months. Thereafter, rotation behavior increased again. We injected hemi-PD r
Externí odkaz:
https://doaj.org/article/286d9c8020ea49aa85f44a1a3c18c54b
Autor:
Veronica Antipova, Andreas Wree, Carsten Holzmann, Teresa Mann, Nicola Palomero-Gallagher, Karl Zilles, Oliver Schmitt, Alexander Hawlitschka
Publikováno v:
Toxins, Vol 10, Iss 7, p 295 (2018)
Different morphological changes in the caudate-putamen (CPu) of naïve rats and mice were observed after intrastriatal botulinum neurotoxin-A (BoNT-A) injection. For this purpose we here studied various motor behaviors in mice (n = 46) longitudinally
Externí odkaz:
https://doaj.org/article/f45b555c5e084fb1adad96f1ee328b5a