Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexander H. Williams"'
Autor:
Alexander H. Williams, Chang-Guo Zhan
The Omicron variant (BA.1) and its sub-variants of the SARS-CoV-2 virus which causes the COVID-19 disease continues to spread across the United States and the World at large. As new sub-variants of SARS-CoV-2 continue to proliferate, a reliable compu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0c70460b2298ae8d444b02f0532f6bb
https://doi.org/10.1101/2022.10.14.512203
https://doi.org/10.1101/2022.10.14.512203
Autor:
Alexander H. Williams, Chang-Guo Zhan
Publikováno v:
The journal of physical chemistry. B. 126(28)
Since the introduction of the novel SARS-CoV-2 virus (COVID-19) in late 2019, various new variants have appeared with mutations that confer resistance to the vaccines and monoclonal antibodies that were developed in response to the wild-type virus. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4e49917134adf794f7ba78ac9d964a
https://pubmed.ncbi.nlm.nih.gov/35817617
https://pubmed.ncbi.nlm.nih.gov/35817617
Autor:
Chang-Guo Zhan, Alexander H. Williams
Publikováno v:
The Journal of Physical Chemistry. B
A recently identified variant of SARS-CoV-2 virus, known as the United Kingdom (UK) variant (lineage B.1.1.7), has an N501Y mutation on its spike protein. SARS-CoV-2 spike protein binds with angiotensin-converting enzyme 2 (ACE2), a key protein for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc5cabf13a83f2daf3891f3abc5ff3c
https://doi.org/10.1021/acs.jpcb.1c00869
https://doi.org/10.1021/acs.jpcb.1c00869
Autor:
Narsimha Reddy Penthala, Peter A. Crooks, Paul L. Prather, Alexander H. Williams, Chang-Guo Zhan, Jing-Fang Yang
Publikováno v:
ACS Chem Neurosci
The cannabinoid (CB) receptors (CB(1)R and CB(2)R) represent a promising therapeutic target for several indications such as nociception and obesity. The ligands with non-selectivity can be traced to the high similarity in the binding sites of both ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d0d1f828ec772eaac24d36d4b40282
https://doi.org/10.1021/acschemneuro.0c00551
https://doi.org/10.1021/acschemneuro.0c00551
Autor:
Kristin L. Begley, Liliia M. Kril, Sean Parkin, Michael V. Fiandalo, Alexander H. Williams, Vivekanandan Subramanian, James L. Mohler, David S. Watt, Chang-Guo Zhan, Chunming Liu, Andrii G Balia, Przemyslaw Wyrebek, Xi Chen, Vitaliy M. Sviripa
Publikováno v:
New J Chem
Androgen-deprivation therapy (ADT) is only a palliative measure, and prostate cancer invariably recurs in a lethal, castration-resistant form (CRPC). Prostate cancer resists ADT by metabolizing weak, adrenal androgens to growth-promoting 5α-dihydrot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8b6e13307eb2233f1368ad6808131b
https://doi.org/10.1039/d0nj02664f
https://doi.org/10.1039/d0nj02664f
Autor:
Alexander H. Williams, Chang-Guo Zhan
Publikováno v:
The journal of physical chemistry. B. 126(12)
Variants of the SARS-CoV-2 virus continue to remain a threat 2 years from the beginning of the pandemic. As more variants arise, and the B.1.1.529 (Omicron) variant threatens to create another wave of infections, a method is needed to predict the bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85dbff32e35d9d1f5c8d52895523ba7a
https://pubmed.ncbi.nlm.nih.gov/35315274
https://pubmed.ncbi.nlm.nih.gov/35315274
Autor:
Dongliang Guan, Md Toufiqur Rahman, Elaine A. Gay, Vineetha Vasukuttan, Kelly M. Mathews, Ann M. Decker, Alexander H. Williams, Chang-Guo Zhan, Chunyang Jin
Publikováno v:
J Med Chem
The central relaxin-3/RXFP3 system plays important roles in stress responses, feeding, and motivation for reward. However, exploration of its therapeutic applications has been hampered by the lack of small molecule ligands and the cross-activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38667039a19d540c8c657d1c4caaaf13
https://pubmed.ncbi.nlm.nih.gov/34855388
https://pubmed.ncbi.nlm.nih.gov/34855388
Autor:
Amal Shoeib, Chang-Guo Zhan, Harvey F. Fulo, Gregory B. Dudley, Christian V. Cabanlong, Alexander H. Williams, Paul L. Prather
Publikováno v:
J Med Chem
Synthetic indole cannabinoids characterized by a 2′,2′-dimethylindan-5′-oyl group at the indole C3 position constitute a new class of ligands possessing high affinity for human CB(2) receptors at a nanomolar concentration and a good selectivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cebac10a71da063017424b59880b91e
https://pubmed.ncbi.nlm.nih.gov/33887913
https://pubmed.ncbi.nlm.nih.gov/33887913
Publikováno v:
Bioorg Med Chem Lett
Cholinesterase inhibitors have long been used in the treatment of Alzheimer’s Disease (AD) via the protection of acetylcholine levels. However, recent research has shown that the specific inhibition of butyrylcholinesterase (BChE) could better amel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45451b17c3627612d0c897d76a82b3f0
https://doi.org/10.1016/j.bmcl.2019.126754
https://doi.org/10.1016/j.bmcl.2019.126754