Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alexander H. Tuttle"'
Publikováno v:
Chemosphere. 218:501-506
Pyraclostrobin is a strobilurin fungicide that inhibits mitochondrial complex III of fungal and mammalian cells. In toxicity studies that were used to estimate the safety factor, pyraclostrobin was added to animal feed or to aqueous vehicles. However
Publikováno v:
Nature Methods. 15:994-996
Inbred mice are preferred over outbred mice with the assumption that they display less trait variability. We compared coefficients of variation and failed to find evidence of greater trait stability in inbred mice. We conclude that contrary to conven
Autor:
Tim Ramsay, Jonathan Kimmelman, Petra Schweinhardt, Sarasa Tohyama, Gary J. Bennett, Alexander H. Tuttle, Jeffrey S. Mogil
Publikováno v:
Pain. 156:2616-2626
Recent failures of clinical trials of novel analgesics designed to treat neuropathic pain have led to much speculation about the underlying reasons. One often discussed possibility is that the placebo response in these trials has increased in recent
Autor:
Alexander H. Tuttle, Kimberly Dossett, Jean-Sebastien Austin, Neil Wu, Shannon N Tansley, Sarasa Tohyama, Jeffrey S. Mogil, Susana G. Sotocinal, Lindsay Gerstein, Boram Ham
Publikováno v:
Genes, brain, and behavior. 18(1)
The potential influence of pain on social behavior in laboratory animals has rarely been evaluated. Using a new assay of social behavior, the tube co-occupancy test (TCOT), we assess propinquity-the tendency to maintain close physical proximity-in mi
Autor:
Alexander H. Tuttle, Mark J. Molinaro, Mark J. Zylka, Jasmine F. Jethwa, Jeffrey S. Mogil, Martin Styner, Juan Prieto, Susana G. Sotocinal
Publikováno v:
Molecular Pain
Grimace scales quantify characteristic facial expressions associated with spontaneous pain in rodents and other mammals. However, these scales have not been widely adopted largely because of the time and effort required for highly trained humans to m
Autor:
Alexander H. Tuttle, Tine Pooters, Kimberly Dossett, Oliver Hardt, Melissa Sukosd, Jean-Sebastien Austin, Hayley Crawhall-Duk, Arkady Khoutorsky, Liane Stein, Christos G. Gkogkas, Lindsey Gerstein, Nahum Sonenberg, Isabelle A. Groves, Sioui Maldonado-Bouchard, Loren J. Martin, Rebecca Pearl, Sarasa Tohyama, Claire M Chan, Philip Leger, Shannon N Tansley, Jeffrey S. Mogil, David Yachnin
Publikováno v:
Tuttle, A H, Tansley, S, Dossett, K, Tohyama, S, Khoutorsky, A, Maldonado-Bouchard, S, Stein, L, Gerstein, L, Crawhall-Duk, H, Pearl, R, Sukosd, M, Leger, P, Hardt, O M, Yachnin, D, Austin, J-S, Chan, C M, Pooters, T, Groves, I, Martin, L J, Sonenberg, N, Gkogkas, C G & Mogil, J S 2017, ' Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes ', Proceedings of the National Academy of Sciences, vol. 114, no. 21, pp. 5515-5520 . https://doi.org/10.1073/pnas.1703477114
Existing assays of social interaction are suboptimal, and none measures propinquity, the tendency of rodents to maintain close physical proximity. These assays are ubiquitously performed using inbred mouse strains and mutations placed on inbred genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa70e8397f90e7c0b890a798fb2edbb9
https://hdl.handle.net/20.500.11820/48515228-1642-4734-8c8c-305b6193eec1
https://hdl.handle.net/20.500.11820/48515228-1642-4734-8c8c-305b6193eec1
Publikováno v:
The Journal of Pain. 20:S31
There is a dire need for new non-opioid analgesics. However, efforts to develop new pain medicines have thus far met with limited success. This failure is partly due to an overreliance on evoked pain measures in preclinical models. Most preclinical m
Autor:
Alexander H. Tuttle, John N. Wood, Jeffrey S. Wieskopf, Ihab Daou, Ariel R. Ase, Philippe Séguéla, Jeffrey S. Mogil, Robert P. Bonin, Geraldine Longo, A. Ribeiro-da-Silva, Y. De Koninck
Publikováno v:
The Journal of Neuroscience. 33:18631-18640
We report a novel model in which remote activation of peripheral nociceptive pathways in transgenic mice is achieved optogenetically, without any external noxious stimulus or injury. Taking advantage of a binary genetic approach, we selectively targe
Publikováno v:
Nature Methods. 16:206-206
In the version of this Comment originally published, the authors omitted a funding source. Grant 5 P50 DA039841 (to E.J.C.) from the US National Institute on Drug Abuse has been added to the Acknowledgements in the HTML and PDF versions of the paper.
Autor:
Jeremy S. Levenstadt, A. Mariette Lenselink, Michel D. Ferrari, Mona Lisa Chanda, Lynn Macrae, Nyrie Israelian, Alexander H. Tuttle, Inna Baran, Georgia Hathaway, Jeffrey S. Mogil, Sabine Spijker, Louise O’Shea, Daniel Low, Cori Atlin, Arn M. J. M. van den Maagdenberg, Elaina Zendegui, Alex Silver, Daniella Guindi
Publikováno v:
Pain, 154(8), 1254-1262. Lippincott Williams & Wilkins
Chanda, M L, Tuttle, A H, Baran, I, Atlin, C, Guindi, D, Hathaway, G, Israelian, N, Levenstadt, J, Low, D, Macrae, L, O'Shea, L, Silver, A, Zendegui, E, Lenselink, A M, Spijker, S, Ferrari, M D & Mogil, J S 2013, ' Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice ', Pain, vol. 154, no. 8, pp. 1254-1262 . https://doi.org/10.1016/j.pain.2013.03.038
PAIN, 154(8), 1254-1262
Chanda, M L, Tuttle, A H, Baran, I, Atlin, C, Guindi, D, Hathaway, G, Israelian, N, Levenstadt, J, Low, D, Macrae, L, O'Shea, L, Silver, A, Zendegui, E, Lenselink, A M, Spijker, S, Ferrari, M D & Mogil, J S 2013, ' Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice ', Pain, vol. 154, no. 8, pp. 1254-1262 . https://doi.org/10.1016/j.pain.2013.03.038
PAIN, 154(8), 1254-1262
Migraine is a highly prevalent, disabling and complex episodic brain disorder whose pathogenesis is poorly understood, due in part to the lack of valid animal models. Here we report behavioral evidence of hallmark migraine features, photophobia and u