Výsledky vyhledávání - "Alexander H. Lucas"

Akademický článek

Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp

Autor: Jacinto López-Sagaseta, Peter T. Beernink, Federica Bianchi, Laura Santini, Elisabetta Frigimelica, Alexander H. Lucas, Mariagrazia Pizza, Matthew J. Bottomley

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Factor H binding protein (fHbp) is a meningococcal virulence factor and a component of vaccines against serogroup B Neisseria meningitidis. Here, the authors characterize the vaccine-elicited human antibody Fab 1A12 and present both the free and the

Externí odkaz: https://doaj.org/article/45a02285ed024573983982388854fecb

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Akademický článek

Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein

Autor: Peter T. Beernink, Serena Giuntini, Isabella Costa, Alexander H. Lucas, Dan M. Granoff

Publikováno v: mBio, Vol 6, Iss 3 (2015)

ABSTRACT Two licensed serogroup B meningococcal vaccines contain factor H binding protein (FHbp). The antigen specifically binds human FH, which downregulates complement. In wild-type mice whose mouse FH does not bind to FHbp vaccines, the serum anti

Externí odkaz: https://doaj.org/article/5ab94d1bfd9a40c8ad446477965f1842

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Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp

Autor: Matthew J. Bottomley, Alexander H. Lucas, Jacinto López-Sagaseta, Laura Santini, Peter T. Beernink, Mariagrazia Pizza, Elisabetta Frigimelica, Federica Bianchi

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
'Nature Communications ', vol: 9, pages: 528-1-528-12 (2018)

Data obtained recently in the United Kingdom following a nationwide infant immunization program against serogroup B Neisseria meningitidis (MenB) reported >80% 4CMenB vaccine-mediated protection. Factor H-binding protein (fHbp) is a meningococcal vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87328b03f44554d93a10ed6f93079468
http://link.springer.com/article/10.1038/s41467-018-02827-7

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Differential Idiotype Utilization for the In Vivo Type 14 Capsular Polysaccharide-Specific Ig Responses to Intact Streptococcus pneumoniae versus a Pneumococcal Conjugate Vaccine

Autor: Jesus Colino, Clifford M. Snapper, Leyu Liu, Leah Duke, Quanyi Chen, Alexander H. Lucas, Swadhinya Arjunaraja

Publikováno v: The Journal of Immunology. 189:575-586

Murine IgG responses specific for the capsular polysaccharide (pneumococcal capsular polysaccharide serotype 14; PPS14) of Streptococcus pneumoniae type 14 (Pn14), induced in response to intact Pn14 or a PPS14–protein conjugate, are both dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266c6c326ffec35e5b8b299546f178b1
https://doi.org/10.4049/jimmunol.1200599

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Carbohydrate moieties as vaccine candidates: Meeting summary

Autor: M. Kronenberg, Kate Rittenhouse-Olson, Alexander H. Lucas, Christopher E. Taylor, D. Wang, John R. Schreiber, Michael A. Apicella

Publikováno v: Vaccine. 28:1121-1131

In September 2007, a meeting entitled 'Carbohydrate Moieties as Vaccine Candidates' was held at the National Institutes of Health (Bethesda, MD). This meeting brought together scientists from a number of disciplines to address issues concerning carbo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2aafd97738bd9e9c9d75725112efbdbc
https://doi.org/10.1016/j.vaccine.2008.05.055

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Genome-based identification and characterization of a putative mucin-binding protein from the surface of Streptococcus pneumoniae

Autor: James E. Littlejohn, Alexander H. Lucas, Michael Y. Galperin, Hannah Nayakanti, Daniel J. Rigden, Daniela Bumbaca, Mark J. Jedrzejas

Publikováno v: Proteins: Structure, Function, and Bioinformatics. 66:547-558

Streptococcus pneumoniae open reading frame SP1492 encodes a surface protein that contains a novel conserved domain similar to the repeated fragments of mucin-binding proteins from lactobacilli and lactococci. To investigate the functional role(s) of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7078b505d903e7076d12857899c86ff6
https://doi.org/10.1002/prot.21205

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Potential for Autoimmune Pathogenesis of Rift Valley Fever Virus Retinitis

Autor: Alexander H. Lucas, Angelle Desiree LaBeaud, Clarence J. Peters, Samuel Muiruri, John C. Morrill, Eric Muchiri, Charles H. King, James W. Kazura, Shoshana Newman-Gerhardt

Publikováno v: The American Journal of Tropical Medicine and Hygiene. 89:495-497

Rift Valley Fever (RVF) is a significant threat to human health because it can progress to retinitis, encepha- litis, and hemorrhagic fever. The timing of onset of Rift Valley Fever virus (RVFV) retinitis suggests an autoimmune origin. To determine w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d9cdbbc5e6b0641dc7967fe694fd5a
https://doi.org/10.4269/ajtmh.12-0562

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The Capsule of Bacillus anthracis Behaves as a Thymus-Independent Type 2 Antigen

Autor: Taia T. Wang, Alexander H. Lucas

Publikováno v: Infection and Immunity. 72:5460-5463

Bacillus anthracis is an encapsulated, endospore-forming, gram-positive rod and is the causative agent of anthrax (1, 8). Pathogenicity of B. anthracis depends upon elaboration of both toxins and capsule. The capsule, a homopolymer of d-glutamic acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb1a0605ed75a4fb553a65656010560
https://doi.org/10.1128/iai.72.9.5460-5463.2004

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