Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Alexander H Stegh"'
Autor:
Amy B Heimberger, David M Ashley, Charles David James, Alexander H Stegh, Michael A Curran, Peng Zhang, Justin T Low, Hinda Najem, Akanksha Sanjay Mahajan, Shashwat Tripathi
Publikováno v:
F1000Research, Vol 11 (2022)
Median survival of patients with glioblastoma (GBM) treated with standard of care which consists of maximal safe resection of the contrast-enhancing portion of the tumor followed by radiation therapy with concomitant adjuvant temozolomide (TMZ) remai
Externí odkaz:
https://doaj.org/article/087941a9a6a140c686f1b957e6d06943
Autor:
Andrea E. Calvert, Alexandra Chalastanis, Yongfei Wu, Lisa A. Hurley, Fotini M. Kouri, Yingtao Bi, Maureen Kachman, Jasmine L. May, Elizabeth Bartom, Youjia Hua, Rama K. Mishra, Gary E. Schiltz, Oleksii Dubrovskyi, Andrew P. Mazar, Marcus E. Peter, Hongwu Zheng, C. David James, Charles F. Burant, Navdeep S. Chandel, Ramana V. Davuluri, Craig Horbinski, Alexander H. Stegh
Publikováno v:
Cell Reports, Vol 19, Iss 9, Pp 1858-1873 (2017)
Oncogenic mutations in two isocitrate dehydrogenase (IDH)-encoding genes (IDH1 and IDH2) have been identified in acute myelogenous leukemia, low-grade glioma, and secondary glioblastoma (GBM). Our in silico and wet-bench analyses indicate that non-mu
Externí odkaz:
https://doaj.org/article/f4d292ac8f8346f8ab26ed8e258f99d4
Publikováno v:
Antioxidants & Redox Signaling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c64ea01bad3853580df1c1763a0e5d0
https://doi.org/10.1089/ars.2023.0262
https://doi.org/10.1089/ars.2023.0262
Autor:
C. David James, Theodore Nicolaides, Nicholas Butowski, Jann N. Sarkaria, Francis J. Giles, Andrew P. Mazar, Alexander H. Stegh, Shi-Yuan Cheng, Jeffrey J. Raizer, Andrew T. Parsa, Dennis Brown, Wang Shen, Tsun-Wen Yao, Tomoko Ozawa, Yasuyuki Yoshida
Supplementary Figure 1: NT113 Chemical Structure; Supplementary Figure 2: A) Relative expression of endogenous wild-type EGFR in parental U87 cells (U87p) vs. U87 cells transduced with EGFRvIII retrovirus (U87vIII). B) Relative expression of EGFRwt,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bbd5bea4202ddc0551d890169f635ab
https://doi.org/10.1158/1535-7163.22502070
https://doi.org/10.1158/1535-7163.22502070
Autor:
C. David James, Theodore Nicolaides, Nicholas Butowski, Jann N. Sarkaria, Francis J. Giles, Andrew P. Mazar, Alexander H. Stegh, Shi-Yuan Cheng, Jeffrey J. Raizer, Andrew T. Parsa, Dennis Brown, Wang Shen, Tsun-Wen Yao, Tomoko Ozawa, Yasuyuki Yoshida
Supplementary Table 1: Selected IC50 results from NT113 screen of 130 tyrosine kinases; Supplementary Table 2: Inhibitor Tissue Concentrations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581846e2123c3161713fb0930ac87d58
https://doi.org/10.1158/1535-7163.22502067
https://doi.org/10.1158/1535-7163.22502067
Autor:
C. David James, Theodore Nicolaides, Nicholas Butowski, Jann N. Sarkaria, Francis J. Giles, Andrew P. Mazar, Alexander H. Stegh, Shi-Yuan Cheng, Jeffrey J. Raizer, Andrew T. Parsa, Dennis Brown, Wang Shen, Tsun-Wen Yao, Tomoko Ozawa, Yasuyuki Yoshida
Supplementary Figure 4: Plasma PK results associated with oral administration of 5 mg/kg NT113 in rats.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8801e63758f8f13981fc9107533858
https://doi.org/10.1158/1535-7163.22502073
https://doi.org/10.1158/1535-7163.22502073
Autor:
C. David James, Theodore Nicolaides, Nicholas Butowski, Jann N. Sarkaria, Francis J. Giles, Andrew P. Mazar, Alexander H. Stegh, Shi-Yuan Cheng, Jeffrey J. Raizer, Andrew T. Parsa, Dennis Brown, Wang Shen, Tsun-Wen Yao, Tomoko Ozawa, Yasuyuki Yoshida
Supplementary Figure 3: Comparison of U87 and U87vIII viability response to increasing concentrations of NT113
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed144dbc6af49e096061e3489047509
https://doi.org/10.1158/1535-7163.22502076
https://doi.org/10.1158/1535-7163.22502076
Autor:
Alexander H. Stegh, Serena Tommasini-Ghelfi, Kevin Murnan, Daniel Wahl, Lisa A. Hurley, Corey Dussold
Publikováno v:
Neuro Oncol
Increased de novo synthesis, mobilization and uptake of fatty acids are required to provide sufficient lipids for membrane biogenesis in support of rapid tumor cell division and growth. In addition to their structural roles as components of the plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a4be238cbc3dacb57b4e841f7ce8c0
https://europepmc.org/articles/PMC8598688/
https://europepmc.org/articles/PMC8598688/
Autor:
Sean Sachdev, Lisa A. Hurley, Roger Stupp, Alexander H. Stegh, Timothy L. Sita, Corey Dussold, Michael Drumm, Craig Horbinski, Kevin Murnan, Akanksha Mahajan, Serena Tommasini-Ghelfi
Publikováno v:
Neuro Oncol
PURPOSE Growing evidence indicates that the neurotransmitters dysregulated in psychiatric disorders are similarly dysregulated in glioblastoma (GBM) biology. GBM cells are dependent on bountiful neuronal glutamate, utilize elevated dopamine receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f7c7f762f62b6a426889e63e63976d
https://europepmc.org/articles/PMC8598562/
https://europepmc.org/articles/PMC8598562/
Autor:
Shashwat Tripathi, Hinda Najem, Akanksha Sanjay Mahajan, Peng Zhang, Justin T Low, Alexander H Stegh, Michael A Curran, David M Ashley, Charles David James, Amy B Heimberger
Publikováno v:
F1000Research. 11:1010
Median survival of patients with glioblastoma (GBM) treated with standard of care which consists of maximal safe resection of the contrast-enhancing portion of the tumor followed by radiation therapy with concomitant adjuvant temozolomide (TMZ) remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0a7c5d184c0add841ba8b180253df0
https://doi.org/10.12688/f1000research.125163.1
https://doi.org/10.12688/f1000research.125163.1