Výsledky vyhledávání - "Alexander Hümmer"

The Chiptip: A Novel Tool for Automated Patch Clamp

Autor: Uwe Czubayko, Dirck Lassen, Alexander Hümmer, Andjelko Golubovic, Martina Knirsch, Albrecht Lepple-Wienhues

Publikováno v: Combinatorial Chemistry & High Throughput Screening. 12:73-77

To facilitate automated patch clamp measurements of ion channels in cells, the development of an all-glass Chiptip pipette is reported that may be combined with the previously described Flip-the-Tip technology. A single measurement requires less than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8ff1c7434035d9383493b64b4fac76
https://doi.org/10.2174/138620709787047984

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G Protein β2 Subunit-derived Peptides for Inhibition and Induction of G Protein Pathways

Autor: Jing Han, Matthias Buck, Mian Xie, Rosa L. Moreno, Stefan Herlitze, Xiang Li, Alexander Hümmer, Katya Verushka Melnik-Martinez, Melanie D. Mark

Publikováno v: Journal of Biological Chemistry. 280:23945-23959

Voltage-gated Ca2+ channels of the N-, P/Q-, and R-type and G protein inwardly rectifying K+ channels (GIRK) are modulated via direct binding of G proteins. The modulation is mediated by G protein βγ subunits. By using electrophysiological recordin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::839eb86f2554168b2772dc946c0ba785
https://doi.org/10.1074/jbc.m414078200

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Competitive and Synergistic Interactions of G Protein β2 and Ca2+ Channel β1b Subunits with Cav2.1 Channels, Revealed by Mammalian Two-hybrid and Fluorescence Resonance Energy Transfer Measurements

Autor: Rosa L. Moreno, Stefan Herlitze, Melanie D. Mark, Alexander Hümmer, Oliver Delzeith, Shannon R. Gomez

Publikováno v: Journal of Biological Chemistry. 278:49386-49400

Presynaptic Ca2+ channels are inhibited by metabotropic receptors. A possible mechanism for this inhibition is that G protein betagamma subunits modulate the binding of the Ca2+ channel beta subunit on the Ca2+ channel complex and induce a conformati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2225ff6d8ddac7a8596ac61cf768431
https://doi.org/10.1074/jbc.m306645200

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Targeting Mechanisms of High Voltage-Activated Ca2+Channels

Autor: Jing Han, Rosa L. Moreno, Mian Xie, Alexander Hümmer, Melanie D. Mark, Katya Verushka Melnik-Martinez, Stefan Herlitze

Publikováno v: Journal of Bioenergetics and Biomembranes. 35:621-637

Functional voltage-dependent Ca2+ channel complexes are assembled by three to four subunits: alpha1, beta, alpha2delta subunits (C. Leveque et al., 1994, J. Biol Chem. 269, 6306-6312; M. W. McEnery et al., 1991, Proc. Natl. Acad. Sci. U.S.A. 88, 1109

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb6bf702db79d458b2cd8e1ceb16900
https://doi.org/10.1023/b:jobb.0000008027.19384.c0

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Dynamic ventricular overdrive stimulation in atrial fibrillation: effects on ventricular rate irregularity, ventricular pacing, and fusion beats

Autor: Guido Ritscher, Peter Boileau, Harald Marschang, Johannes Brachmann, Michael Benser, Klaus-Jürgen Gutleben, Georg Nölker, Benoit Hallier, Stefan Asbach, Anil M. Sinha, Alexander Hümmer

Publikováno v: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 13(12)

Aims In pacemaker patients with preserved atrio-ventricular (AV) conduction, atrial fibrillation (AF) can lead to symptomatic ventricular rate irregularity and loss of ventricular stimulation. We tested if dynamic ventricular overdrive (DVO) as a pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a12ed3bec1e7fde172d886f7bd2763
https://pubmed.ncbi.nlm.nih.gov/21873626

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Flip-the-tip: automated patch clamping based on glass electrodes

Autor: Michael, Fejtl, Uwe, Czubayko, Alexander, Hümmer, Tobias, Krauter, Albrecht, Lepple-Wienhues

Publikováno v: Methods in molecular biology (Clifton, N.J.). 403

A conventional borosilicate glass patch pipette is glued into a plastic jacket, forming the entity of a FlipTip. One or two three-channel modules of recording tip sockets are mounted on a liquid handler platform to take up FlipTips. The tip sockets a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::20dd189fb84d7d17a3095347c8eee876
https://pubmed.ncbi.nlm.nih.gov/18827988

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