Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alexander Höing"'
Autor:
Neda Rafieiolhosseini, Matthias Killa, Thorben Neumann, Niklas Tötsch, Jean-Noël Grad, Alexander Höing, Thies Dirksmeyer, Jochen Niemeyer, Christian Ottmann, Shirley K. Knauer, Michael Giese, Jens Voskuhl, Daniel Hoffmann
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 1322-1331 (2022)
The 14-3-3 protein family, one of the first discovered phosphoserine/phosphothreonine binding proteins, has attracted interest not only because of its important role in the cell regulatory processes but also due to its enormous number of interactions
Externí odkaz:
https://doaj.org/article/d60fc9a2fd0f4a07b702ee811fd82535
Autor:
Tim Rick, Vanessa Kreiling, Alexander Höing, Svenja Fiedler, Timo Glatter, Wieland Steinchen, Georg Hochberg, Heike Bähre, Roland Seifert, Gert Bange, Shirley K. Knauer, Peter L. Graumann, Kai M. Thormann
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-14 (2022)
Abstract In bacteria, the monopolar localization of enzymes and protein complexes can result in a bimodal distribution of enzyme activity between the dividing cells and heterogeneity of cellular behaviors. In Shewanella putrefaciens, the multidomain
Externí odkaz:
https://doaj.org/article/b0a30200274b4b3fb7c321c53bb06cbe
Autor:
Astrid Hensel, Paul Stahl, Lisa Moews, Lena König, Rutuja Patwardhan, Alexander Höing, Nina Schulze, Perihan Nalbant, Roland H. Stauber, Shirley K. Knauer
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104355- (2022)
Summary: The unique threonine protease Tasp1 impacts not only ordered development and cell proliferation but also pathologies. However, its substrates and the underlying molecular mechanisms remain poorly understood. We demonstrate that the unconvent
Externí odkaz:
https://doaj.org/article/aa24896ee8034a1982f47721b9ec1424
Autor:
Alexander Höing, Abbna Kirupakaran, Christine Beuck, Marius Pörschke, Felix C. Niemeyer, Theresa Seiler, Laura Hartmann, Peter Bayer, Thomas Schrader, Shirley K. Knauer
Publikováno v:
Biomacromolecules. 23:4504-4518
Many natural proteins contain flexible loops utilizing well-defined complementary surface regions of their interacting partners and usually undergo major structural rearrangements to allow perfect binding. The molecular recognition of such flexible s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6bc95bf4c4daf08569e6a0ea873c0f1
https://doi.org/10.1021/acs.biomac.2c00652
https://doi.org/10.1021/acs.biomac.2c00652
Autor:
Alexander Höing, Robin Struth, Christine Beuck, Neda Rafieiolhosseini, Daniel Hoffmann, Roland H. Stauber, Peter Bayer, Jochen Niemeyer, Shirley K. Knauer
Publikováno v:
RSC Advances. 12:34176-34184
Therapy resistance remains a challenge for the clinics. Here, dual-active chemicals that simultaneously inhibit independent functions in disease-relevant proteins are desired though highly challenging. As a model, we here addressed the unique proteas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1de2807b6a319e7cdfedcf5cd95efc
https://doi.org/10.1039/d2ra06019a
https://doi.org/10.1039/d2ra06019a
Autor:
Justin Dubbert, Alexander Höing, Nadine Graupner, Ľubomír Rajter, Micah Dunthorn, Shirley K. Knauer, Anzhela Galstyan, Fabio Rizzo, Jens Voskuhl
A library of eight different cationic emitters with emission properties in solution and in solid-state (solution and solid-state emitters – SSSE) is presented. These compounds, bearing either ammonium or pyridinium groups, have been investigated re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7155e4829963994086120ac15eae1257
https://www.ncbi.nlm.nih.gov/pubmed/37042483
https://www.ncbi.nlm.nih.gov/pubmed/37042483
Autor:
Alexander Höing, Andrea Sowa, Jens Voskuhl, Shirley K. Knauer, Anzhela Galstyan, Ulrich Dobrindt
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
In this contribution we report on the synthesis, characterization and application of water‐soluble zinc(II) phthalocyanines, which are decorated with four or eight umbelliferone moieties for photodynamic therapy (PDT). These compounds are linked pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509ccf41c28ecb933a973add8688859d
https://doi.org/10.1002/chem.202102255
https://doi.org/10.1002/chem.202102255
Autor:
Alexander Höing, Laura Hartmann, Serap Ueclue, Matthias Killa, Shirley K. Knauer, Peter Pasch, Jens Voskuhl
Publikováno v:
Chemical Communications. 57:3091-3094
A novel strategy to inhibit the oncologically relevant protease Taspase1 is explored by developing PEGylated macromolecular ligands presenting the supramolecular binding motif guanidiniocarbonylpyrrole (GCP). Taspase1 requires interaction of its nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa3b3bb410ef3be0de35142199db88f
https://doi.org/10.1039/d0cc07139k
https://doi.org/10.1039/d0cc07139k
Publikováno v:
Chemical Communications. 56:7653-7656
In this communication we report on the synthesis and application of axially functionalized boron-subphthalocyanines (SubPC) which are able to form host-guest complexes with cyclodextrins. Here, a tert-butylphenyl substituted SubPC was investigated co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e255027a0fcb6107939a046c445f712
https://doi.org/10.1039/d0cc03065a
https://doi.org/10.1039/d0cc03065a
Autor:
Jens Voskuhl, Astrid Hensel, Shirley K. Knauer, Alexander Höing, Matthias Killa, Marius Heimann, Lisa Moews, Alexander Zimmermann
Publikováno v:
ChemMedChem. 17(1)
Taspase1 is a unique protease not only pivotal for embryonic development but also implicated in leukemia as well as solid tumors. As such, it is a promising target in cancer therapy, although only a limited number of Taspase1 inhibitors lacking gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c16e01967ca9a73e007a473a0738e09
https://pubmed.ncbi.nlm.nih.gov/34623765
https://pubmed.ncbi.nlm.nih.gov/34623765