Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Alexander Granick"'
Autor:
Alexander Medvedev, Matt Moeser, Liubov Medvedeva, Elena Martsen, Alexander Granick, Lydia Raines, Kristen Gorman, Benjamin Lin, Ming Zeng, Keith A. Houck, Sergei S. Makarov
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Nuclear receptors (NR) are ligand-modulated transcription factors that regulate multiple cell functions and thus represent excellent drug targets. However, due to a considerable NR structural homology, NR ligands often interact with multiple
Externí odkaz:
https://doaj.org/article/7b4fcb73a0c54a51a995d71c913737bf
Autor:
Alexander Medvedev, Ming Zeng, Kristen L Gorman, Alexander Granick, Sergei S. Makarov, Benjamin Lin, Lydia Raines, Keith A. Houck, Elena Martsen, Matthew Moeser, Liubov Medvedeva
Nuclear receptors (NR) are ligand-modulated transcription factors that regulate multiple cell functions and thus represent excellent drug targets. However, due to a considerable NR structural homology, NR ligands often interact with multiple receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf091b36876badb30b5f1f020b69d6b
https://doi.org/10.21203/rs.3.rs-478112/v1
https://doi.org/10.21203/rs.3.rs-478112/v1
Autor:
Alexander Medvedev, Keith A. Houck, Alexander Granick, Sergei Makarov, Ming Zeng, Lydia Raines, Elena Martsen, Sergei S. Makarov, Liubov Medvedeva, Matt Moeser
Publikováno v:
Science Advances. 4
Assessing the biological activity of compounds is an essential objective of biomedical research. We show that one can infer the bioactivity of compounds by assessing the activity of transcription factors (TFs) that regulate gene expression. Using a m