Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Alexander Goncearenco"'
Publikováno v:
Current Research in Structural Biology, Vol 7, Iss , Pp 100142- (2024)
Binding of nucleotides and their derivatives is one of the most ancient elementary functions dating back to the Origin of Life. We review here the works considering one of the key elements in binding of (di)nucleotide-containing ligands – phosphate
Externí odkaz:
https://doaj.org/article/6d225fb39eab47c59ab5526adbc3bd5d
Autor:
Noelia Ferruz, Michael Heinzinger, Mehmet Akdel, Alexander Goncearenco, Luca Naef, Christian Dallago
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 238-250 (2023)
The process of designing biomolecules, in particular proteins, is witnessing a rapid change in available tooling and approaches, moving from design through physicochemical force fields, to producing plausible, complex sequences fast via end-to-end di
Externí odkaz:
https://doaj.org/article/551fa6fbd7244da18697eddc83db91c5
Autor:
Alexander Goncearenco, Brenna A. LaBarre, Hanna M. Petrykowska, Weerachai Jaratlerdsiri, M. S. Riana Bornman, Stephen D. Turner, Vanessa M. Hayes, Laura Elnitski
Publikováno v:
Epigenetics, Vol 16, Iss 5, Pp 537-553 (2021)
Genomes of KhoeSan individuals of the Kalahari Desert provide the greatest understanding of single nucleotide diversity in the human genome. Compared with individuals in industrialized environments, the KhoeSan have a unique foraging and hunting life
Externí odkaz:
https://doaj.org/article/8ea6c26cf29140dfbaa31bd98de06e80
Autor:
Brenna A. LaBarre, Alexander Goncearenco, Hanna M. Petrykowska, Weerachai Jaratlerdsiri, M. S. Riana Bornman, Vanessa M. Hayes, Laura Elnitski
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-14 (2019)
Abstract Background Current array-based methods for the measurement of DNA methylation rely on the process of sodium bisulfite conversion to differentiate between methylated and unmethylated cytosine bases in DNA. In the absence of genotype data this
Externí odkaz:
https://doaj.org/article/ff97df7ff145451ba20a0e893fa63c77
Publikováno v:
Data in Brief, Vol 33, Iss , Pp 106555- (2020)
Here, we present the data of human histone interactomes generated and analysed in the research article by Peng et al., 2020 [1]. The histone interactome data provide a comprehensive mapping of human histone/nucleosome interaction networks by using di
Externí odkaz:
https://doaj.org/article/aea71f0f0f8246cf9c0736ef059f8952
Autor:
Ning Zhang, Yuting Chen, Haoyu Lu, Feiyang Zhao, Roberto Vera Alvarez, Alexander Goncearenco, Anna R. Panchenko, Minghui Li
Publikováno v:
iScience, Vol 23, Iss 3, Pp - (2020)
Summary: Missense mutations may affect proteostasis by destabilizing or over-stabilizing protein complexes and changing the pathway flux. Predicting the effects of stabilizing mutations on protein-protein interactions is notoriously difficult because
Externí odkaz:
https://doaj.org/article/a8375d63c2394331adf0d18d1fe73984
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006981 (2019)
Identifying driver mutations in cancer is notoriously difficult. To date, recurrence of a mutation in patients remains one of the most reliable markers of mutation driver status. However, some mutations are more likely to occur than others due to dif
Externí odkaz:
https://doaj.org/article/3cc3aef3a3fa45d79cf59e94c0aa86af
Autor:
Nitin Roper, Shaojian Gao, Tapan K. Maity, A. Rouf Banday, Xu Zhang, Abhilash Venugopalan, Constance M. Cultraro, Rajesh Patidar, Sivasish Sindiri, Anna-Leigh Brown, Alexander Goncearenco, Anna R. Panchenko, Romi Biswas, Anish Thomas, Arun Rajan, Corey A. Carter, David E. Kleiner, Stephen M. Hewitt, Javed Khan, Ludmila Prokunina-Olsson, Udayan Guha
Publikováno v:
Cell Reports, Vol 26, Iss 10, Pp 2651-2666.e6 (2019)
Summary: Intratumor mutational heterogeneity has been documented in primary non-small-cell lung cancer. Here, we elucidate mechanisms of tumor evolution and heterogeneity in metastatic thoracic tumors (lung adenocarcinoma and thymic carcinoma) using
Externí odkaz:
https://doaj.org/article/a89fb160e8244d76991306067b2f929e
Autor:
Alexey K. Shaytan, Grigoriy A. Armeev, Alexander Goncearenco, Victor B. Zhurkin, David Landsman, Anna R. Panchenko
Publikováno v:
Data in Brief, Vol 7, Iss , Pp 1678-1681 (2016)
We present here raw trajectories of molecular dynamics simulations for nucleosome with linker DNA strands as well as minimalistic nucleosome core particle model. The simulations were done in explicit solvent using CHARMM36 force field. We used this d
Externí odkaz:
https://doaj.org/article/9cd12f03b7364e189d44451bc7c562c1
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 7, p 2113 (2018)
Cancer is a complex disease that is driven by genetic alterations. There has been a rapid development of genome-wide techniques during the last decade along with a significant lowering of the cost of gene sequencing, which has generated widely availa
Externí odkaz:
https://doaj.org/article/72c63a8d23c54853ab3ebc8d7c51bbb5