Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Alexander Giannaras"'
Publikováno v:
European Journal of Pharmacology. 506:265-271
Leukotrienes and histamine are thought to play important roles in the development of dermatitis. This study evaluated the in vivo efficacy of 5-{4-[(aminocarbonyl)(hydroxy)amino]but-1-ynyl}-2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}e
Autor:
Alexander Giannaras, Nathalie Van houtvin, Dorin Preda, Dong Zou, Maggi Burton, Frédéric Denonne, Patrick Pasau, Jean-Marie Nicolas, Alan J. Dipesa, Andrew Volosov, Sophie Binet, Philippe Collart, Seema Kumar, Sabine Defays, Maria Eckert, Cecile Pegurier, Beth Levine
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(12)
The synthesis and structure-activity relationships against the C3a receptor of a series of substituted aminopiperidine derivatives are reported. DMPK properties and functional activities of selected compounds are described. The compounds obtained are
Autor:
Alexander Volosov, Tamsin Mansley, Patrick Pasau, Frédéric Denonne, Sophie Binet, Jean-Marie Nicolas, Philippe Collart, Alan J. Dipesa, Seema Kumar, Alexander Giannaras, Maggi Burton, Dong Zou, Dorin Preda, Tanmoy Ganguly, Karin J. Stebbins, Florence Maounis, Timothy A. Lewis
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(12)
The synthesis and in vitro binding of several new arginine-containing C3aR ligands are reported. DMPK properties and functional activities of selected compounds have been evaluated. One compound is shown to be active in an in vivo model of airway inf