Anti-SARS-CoV-2 total immunoglobulin and neutralising antibody responses in healthy blood donors throughout the COVID-19 pandemic: a longitudinal observational study

Autor: Yukino Gütlin, Diana Albertos Torres, Alexander Gensch, Ann-Kathrin Schlotterbeck, Laurent Stöger, Stefanie Heller, Laura Infanti, Güliz Tuba Barut, Volker Thiel, Karoline Leuzinger, Hans H. Hirsch, Andreas Buser, Adrian Egli

Publikováno v: Swiss Medical Weekly, Vol 154, Iss 7 (2024)

INTRODUCTION: Quantifying antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and neutralising antibodies may help to understand protection at the individual and population levels. Determination of neutralising antibodies

Externí odkaz: https://doaj.org/article/846c1a70bcfc4b61b9749a677bb5b646

SARS-CoV-2 outbreak in a tri-national urban area is dominated by a B.1 lineage variant linked to a mass gathering event.

Autor: Madlen Stange, Alfredo Mari, Tim Roloff, Helena Mb Seth-Smith, Michael Schweitzer, Myrta Brunner, Karoline Leuzinger, Kirstine K Søgaard, Alexander Gensch, Sarah Tschudin-Sutter, Simon Fuchs, Julia Bielicki, Hans Pargger, Martin Siegemund, Christian H Nickel, Roland Bingisser, Michael Osthoff, Stefano Bassetti, Rita Schneider-Sliwa, Manuel Battegay, Hans H Hirsch, Adrian Egli

Publikováno v: PLoS Pathogens, Vol 17, Iss 3, p e1009374 (2021)

The first case of SARS-CoV-2 in Basel, Switzerland was detected on February 26th 2020. We present a phylogenetic study to explore viral introduction and evolution during the exponential early phase of the local COVID-19 outbreak from February 26th un

Externí odkaz: https://doaj.org/article/39815d5616034132b1e46bb8608521fb

Determinants of SARS-CoV-2 transmission to guide vaccination strategy in an urban area

Autor: Sarah C Brüningk, Juliane Klatt, Madlen Stange, Alfredo Mari, Myrta Brunner, Tim-Christoph Roloff, Helena M B Seth-Smith, Michael Schweitzer, Karoline Leuzinger, Kirstine K Søgaard, Diana Albertos Torres, Alexander Gensch, Ann-Kathrin Schlotterbeck, Christian H Nickel, Nicole Ritz, Ulrich Heininger, Julia Bielicki, Katharina Rentsch, Simon Fuchs, Roland Bingisser, Martin Siegemund, Hans Pargger, Diana Ciardo, Olivier Dubuis, Andreas Buser, Sarah Tschudin-Sutter, Manuel Battegay, Rita Schneider-Sliwa, Karsten M Borgwardt, Hans H Hirsch, Adrian Egli

Publikováno v: medRxiv
Virus Evolution

Background Transmission chains within small urban areas (accommodating∼30% of the European population) greatly contribute to case burden and economic impact during the ongoing COVID-19 pandemic, and should be a focus for preventive measures to achi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::febfd1175c8a148402054adcdc291cac
https://edoc.unibas.ch/95288/

Global Genomic Analysis of SARS-CoV-2 RNA Dependent RNA Polymerase Evolution and Antiviral Drug Resistance

Autor: Helena M. B. Seth-Smith, Stefano Bassetti, Kirstine K. Søgaard, Tim Roloff, Manuel Battegay, Alexander Gensch, Leila Tamara Alexander, Michael Schweitzer, Hans H. Hirsch, Martin Siegemund, Alfredo Mari, Madlen Stange, Roland Bingisser, Julia Bielicki, Catia Marzolini, Adrian Egli, Michael Osthoff, Hans Pargger, Christian H. Nickel, Erblin Asllanaj, Gerardo Tauriello, Karoline Leuzinger, Parham Sendi, Torsten Schwede, Aurélien Emmanuel Martinez

Publikováno v: Microorganisms, Vol 9, Iss 1094, p 1094 (2021)
Microorganisms
Mari, Alfredo; Roloff, Tim; Stange, Madlen; Søgaard, Kirstine K; Asllanaj, Erblin; Tauriello, Gerardo; Alexander, Leila Tamara; Schweitzer, Michael; Leuzinger, Karoline; Gensch, Alexander; Martinez, Aurélien E; Bielicki, Julia; Pargger, Hans; Siegemund, Martin; Nickel, Christian H; Bingisser, Roland; Osthoff, Michael; Bassetti, Stefano; Sendi, Parham; Battegay, Manuel; ... (2021). Global Genomic Analysis of SARS-CoV-2 RNA Dependent RNA Polymerase Evolution and Antiviral Drug Resistance. Microorganisms, 9(5) MDPI 10.3390/microorganisms9051094
Volume 9
Issue 5

A variety of antiviral treatments for COVID-19 have been investigated, involving many repurposed drugs. Currently, the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp, encoded by nsp12-nsp7-nsp8) has been targeted by numerous inhibitors, e.g., remdesiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2620eb5f88821b5638349daa75a2fa
https://www.mdpi.com/2076-2607/9/5/1094

SARS-CoV-2 outbreak in a tri-national urban area is dominated by a B.1 lineage variant linked to a mass gathering event

Autor: Myrta Brunner, Karoline Leuzinger, Alexander Gensch, Madlen Stange, Christian H. Nickel, Kirstine K. Søgaard, Helena M. B. Seth-Smith, Adrian Egli, Julia Bielicki, Hans H. Hirsch, Michael Schweitzer, Manuel Battegay, Sarah Tschudin-Sutter, Martin Siegemund, Alfredo Mari, Roland Bingisser, Simon Fuchs, Stefano Bassetti, Tim Roloff, Hans Pargger, Michael Osthoff, Rita Schneider-Sliwa

Publikováno v: PLoS Pathogens, Vol 17, Iss 3, p e1009374 (2021)
PLoS Pathogens

The first case of SARS-CoV-2 in Basel, Switzerland was detected on February 26th 2020. We present a phylogenetic study to explore viral introduction and evolution during the exponential early phase of the local COVID-19 outbreak from February 26th un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f0d14648cee66babcce812aebe47ea