Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alexander G.S. Teague"'
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Colorectal cancers carry multiple mutations. Here, the authors use Drosophilaas a model organism and assess multiple combinations of mutations and their response to various drugs, providing further insight into drug resistance mechanisms.
Externí odkaz:
https://doaj.org/article/e59e5a0467fd4abfb5f65e06e4a7d710
Autor:
Sara Kim, Aye S. Moe, Alexander G.S. Teague, Sindhura Gopinath, Krzysztof Misiukiewicz, Eric E. Schadt, Kendra Yum, Yevgeniy Antipin, John Mascarenhas, Chana Hecht, Patricia Taik, Huan Wang, Jorge Gomez, Robert Sebra, Chetanya Pandya, Michael J. Donovan, Andrew V. Uzilov, Erdem Bangi, Celina Ang, Marshall R. Posner, Isaiah Selkridge, Max Sung, Denis A. Malyshev, Nelson Gruszczynski, Wesley J. Yon, Ross L. Cagan, Chun Yee Lau, Denise Laspina, Peter Smibert, Rong Chen
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102212-(2021)
iScience
iScience
Summary Adenoid cystic carcinoma (ACC) is a rare cancer type that originates in the salivary glands. Tumors commonly invade along nerve tracks in the head and neck, making surgery challenging. Follow-up treatments for recurrence or metastasis includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60174fe7fb0dffeb3dc84c2eea2b6885
http://www.sciencedirect.com/science/article/pii/S2589004221001802
http://www.sciencedirect.com/science/article/pii/S2589004221001802
Autor:
Ross L. Cagan, Chun Yee Lau, Andrew V. Uzilov, Isaiah Selkridge, Nelson Gruszczynski, Denis A. Malyshev, Peter Smibert, Robert Sebra, Kendra Yum, Erdem Bangi, Denise Laspina, Rong Chen, Max Sung, Hope Rainey, Marshall R. Posner, Sara Kim, Alexander G.S. Teague, Michael J. Donovan, Krzysztof Misiukiewicz, Eric E. Schadt, Yevgeniy Antipin, Chana Hecht, Wesley J. Yon, Aye S. Moe, Eric J. Wilck, Aarti Sonia Bhardwaj, Patricia Taik, Celina Ang
Publikováno v:
Science Advances
A novel Drosophila-based approach resulted in a significant response by a patient with KRAS-mutant colorectal cancer.
Colorectal cancer remains a leading source of cancer mortality worldwide. Initial response is often followed by emergent resist
Colorectal cancer remains a leading source of cancer mortality worldwide. Initial response is often followed by emergent resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24982330746ab7ef59a567ed5be1757e
http://europepmc.org/articles/PMC6531007
http://europepmc.org/articles/PMC6531007
Publikováno v:
Cancer Research. 80:B11-B11
Colorectal cancer (CRC) is an extremely complex and genetically diverse disease with few available models that recapitulate the key features of heterogeneity. The Cancer Genome Atlas has identified 30 recurrent mutated genes as drivers of CRC. Indivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37bf4ba826062762438aec2cd2012573
https://doi.org/10.1158/1538-7445.camodels2020-b11
https://doi.org/10.1158/1538-7445.camodels2020-b11
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
The multigenic nature of human tumours presents a fundamental challenge for cancer drug discovery. Here we use Drosophila to generate 32 multigenic models of colon cancer using patient data from The Cancer Genome Atlas. These models recapitulate key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27f16f494a2381bd37dfd0170b23a10
https://pubmed.ncbi.nlm.nih.gov/27897178
https://pubmed.ncbi.nlm.nih.gov/27897178
Autor:
Christene A. Huang, Alexander G.S. Teague, Jay A. Fishman, R. Crepeau, Abraham J. Matar, Vimukthi Pathiraja, Roderick T. Bronson, Thomas R. Spitzer, Raimon Duran-Struuck, Benjamin M. Horner, David H. Sachs
Publikováno v:
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 22(11)
We previously described successful hematopoietic stem cell engraftment across MHC barriers in miniature swine without graft-versus-host disease (GVHD) using novel reduced-intensity conditioning regimens consisting of partial transient recipient T cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe80cdc8bcd21dd14467f80271326407
https://pubmed.ncbi.nlm.nih.gov/27543159
https://pubmed.ncbi.nlm.nih.gov/27543159
Autor:
Isabel M. McMorrow, Ben Horner, Alexander G.S. Teague, Susan V. Westmoreland, John S. Hanekamp, J. Scott Arn, Brian Fishman, Bob Billiter, David H. Sachs, S. Moran, Patricia S. Cho, Beow Y. Yeap, Stuart L. Houser, Raimon Duran-Struuck, Krzysztof J. Wikiel, Diana P. Lo, Aaron S. Fishman, Michael Duggan, Christene A. Huang, Roderick T. Bronson, Kelly K. Ferguson, Thomas R. Spitzer
Publikováno v:
Veterinary Immunology and Immunopathology. 135:243-256
This manuscript reports on five cases of spontaneous myelogenous leukemia, similar to human disease, occurring within highly inbred, histocompatible sublines of Massachusetts General Hospital (MGH) MHC-defined miniature swine. In cases where a neopla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22378387513a499755893a9dfa1c1c8
https://doi.org/10.1016/j.vetimm.2009.12.005
https://doi.org/10.1016/j.vetimm.2009.12.005
Autor:
Benjamin M. Horner, Kelly K. Ferguson, Erica L. Hirsh, Alexander G.S. Teague, Christene A. Huang, Mark A. Randolph, Peter E. M. Butler, Raimon Duran-Struuck
Publikováno v:
Transplantation Proceedings. 41:539-541
Clinical composite tissue allotransplantation can adequately reconstruct defects that are not possible by other means. However, immunosuppressant toxicity limits the use of these techniques. Clinical attempts to reduce the amount of immunosuppression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7254be729a5a360d4b528562efd1af7a
https://doi.org/10.1016/j.transproceed.2009.01.015
https://doi.org/10.1016/j.transproceed.2009.01.015
Autor:
Claudio Murgia, Jessica Esernio, Ross L. Cagan, Owen J. Sansom, Alexander G.S. Teague, Peter Smibert, Nelson Gruszczynski, Erdem Bangi, Caitlyn Yeykal
Publikováno v:
Clinical Cancer Research. 22:34-34
Personalized cancer genomics is providing unprecedented access into the genetic complexity and diversity of human tumors. The next challenge is to utilize this information to establish effective therapeutics. Functional interrogation of cancer genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5aa5a8934a9d3d2b983087709509aa2
https://doi.org/10.1158/1557-3265.pmsclingen15-34
https://doi.org/10.1158/1557-3265.pmsclingen15-34
Autor:
Alexander G.S. Teague, Bram V. Lutton, Stuart L. Houser, Kelly K. Ferguson, Nina Chi, Christene A. Huang, Stephanie N. Goldman, Patricia S. Cho, Sicco H. Popma, David H. Sachs, Beow Y. Yeap, Erica L. Hirsh, John S. Hanekamp, Darin J. Messina
Publikováno v:
Transplantation. 90(5)
Umbilical cord tissue-derived cells (UTC) were targeted as a source of multipotent progenitor cells due to the immune-privileged nature of the maternal-fetal interface (1). UTC have been believed to have a low immunogenic profile because they lack ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00816464ff8bc851e0b5c2b030ccad0
https://pubmed.ncbi.nlm.nih.gov/21451445
https://pubmed.ncbi.nlm.nih.gov/21451445