Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Alexander G. Weil"'
Autor:
Augusto Faria Andrade, Alva Annett, Elham Karimi, Danai Georgia Topouza, Morteza Rezanejad, Yitong Liu, Michael McNicholas, Eduardo G. Gonzalez Santiago, Dhana Llivichuzhca-Loja, Arne Gehlhaar, Selin Jessa, Antonella De Cola, Bhavyaa Chandarana, Caterina Russo, Damien Faury, Geoffroy Danieau, Evan Puligandla, Yuhong Wei, Michele Zeinieh, Qing Wu, Steven Hebert, Nikoleta Juretic, Emily M. Nakada, Brian Krug, Valerie Larouche, Alexander G. Weil, Roy W. R. Dudley, Jason Karamchandani, Sameer Agnihotri, Daniela F. Quail, Benjamin Ellezam, Liza Konnikova, Logan A. Walsh, Manav Pathania, Claudia L. Kleinman, Nada Jabado
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Histone H3-mutant gliomas are deadly brain tumors characterized by a dysregulated epigenome and stalled differentiation. In contrast to the extensive datasets available on tumor cells, limited information exists on their tumor microenvironme
Externí odkaz:
https://doaj.org/article/69253d46aa2e495fb76b6cda5b46af80
Autor:
Sami Obaid, Guido I. Guberman, Etienne St-Onge, Emma Campbell, Manon Edde, Layton Lamsam, Alain Bouthillier, Alexander G. Weil, Alessandro Daducci, François Rheault, Dang K. Nguyen, Maxime Descoteaux
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
IntroductionOperculo-insular epilepsy (OIE) is a rare condition amenable to surgery in well-selected cases. Despite the high rate of neurological complications associated with OIE surgery, most postoperative deficits recover fully and rapidly. We pro
Externí odkaz:
https://doaj.org/article/6d84c705977f49c6a2a5cc926c668e49
Autor:
Farbod Niazi, Aline Han, Lauren Stamm, Nathan A. Shlobin, Catherine Korman, Thien S. Hoang, Agnieszka Kielian, Genevieve Du Pont-Thibodeau, Laurence Ducharme Crevier, Philippe Major, Dang K. Nguyen, Alain Bouthillier, George M. Ibrahim, Aria Fallah, Aristides Hadjinicolaou, Alexander G. Weil
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundRefractory (RSE) and super-refractory status epilepticus (SRSE) are serious neurological conditions requiring aggressive management. Beyond anesthetic agents, there is a lack of evidence guiding management in these patients. This systematic
Externí odkaz:
https://doaj.org/article/b248978e221c4841a5efcb0f500c31c0
Autor:
Karim Mithani, Oliver L. Richards, Mark Ebden, Noor Malik, Ladina Greuter, Hrishikesh Suresh, Farbod Niazi, Flavia Venetucci Gouveia, Elysa Widjaja, Shelly Weiss, Elizabeth Donner, Hiroshi Otsubo, Ayako Ochi, Puneet Jain, Ivanna Yau, Elizabeth N. Kerr, James T. Rutka, James M. Drake, Alexander G. Weil, George M Ibrahim
Publikováno v:
NeuroImage: Clinical, Vol 42, Iss , Pp 103613- (2024)
Background and objectives: Gelastic seizures due to hypothalamic hamartomas (HH) are challenging to treat, in part due to an incomplete understanding of seizure propagation pathways. Although magnetic resonance imaging-guided laser interstitial therm
Externí odkaz:
https://doaj.org/article/37bb4c2d8def47998149a8827eab2218
Autor:
Sami Obaid, Jia‐Shu Chen, George M. Ibrahim, Alain Bouthillier, Evan Dimentberg, Werner Surbeck, Elena Guadagno, Tristan Brunette‐Clément, Nathan A. Shlobin, Aidan Shulkin, Andrew T. Hale, Luke D. Tomycz, Marec Von Lehe, Michael Scott Perry, Francine Chassoux, Viviane Bouilleret, Delphine Taussig, Martine Fohlen, Georg Dorfmuller, Koichi Hagiwara, Jean Isnard, Chima O. Oluigbo, Naoki Ikegaya, Dang K. Nguyen, Aria Fallah, Alexander G. Weil
Publikováno v:
Epilepsia Open, Vol 8, Iss 1, Pp 12-31 (2023)
Abstract Insular epilepsy (IE) is an increasingly recognized cause of drug‐resistant epilepsy amenable to surgery. However, concerns of suboptimal seizure control and permanent neurological morbidity hamper widespread adoption of surgery for IE. We
Externí odkaz:
https://doaj.org/article/85bcda8e79194d649aed912b82a55388
Autor:
Daniele C. Wolf, Nathalie T. Sanon, Alexandra O. S. Cunha, Jia-Shu Chen, Tarek Shaker, Abdul-Rahman Elhassan, Antônia Sâmia Fernandes do Nascimento, Graziella Di Cristo, Alexander G. Weil
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Sexual differentiation of the brain is influenced by testosterone and its metabolites during the perinatal period, when many aspects of brain development, including the maturation of GABAergic transmission, occur. Whether and how testosteron
Externí odkaz:
https://doaj.org/article/708a01107ad54f98a88d85ee5edb2f12
Autor:
Rabah Dabouz, Colin W. H. Cheng, Pénélope Abram, Samy Omri, Gael Cagnone, Khushnouma Virah Sawmy, Jean-Sébastien Joyal, Michel Desjarlais, David Olson, Alexander G. Weil, William Lubell, José Carlos Rivera, Sylvain Chemtob
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-19 (2020)
Abstract Background Inflammation and particularly interleukin-1β (IL-1β), a pro-inflammatory cytokine highly secreted by activated immune cells during early AMD pathological events, contribute significantly to retinal neurodegeneration. Here, we id
Externí odkaz:
https://doaj.org/article/506aa30b38074c1d9d6c7c66eb9f544b
Autor:
Gabriel Crevier‐Sorbo, Tristan Brunette‐Clément, Edgar Medawar, Francois Mathieu, Benjamin R. Morgan, Laureen Hachem, Aria Fallah, Alexander G. Weil, George M. Ibrahim
Publikováno v:
Epilepsia Open, Vol 5, Iss 2, Pp 190-197 (2020)
Abstract Objective The global burden of pediatric epilepsy is disproportionately concentrated in low‐ and middle‐income countries (LMICs). However, little is known about the effectiveness of current treatment programs in this setting. We present
Externí odkaz:
https://doaj.org/article/f355703f3bad42dca8c1fd3644246a37
Autor:
Tarek Shaker, Bidisha Chattopadhyaya, Bénédicte Amilhon, Graziella Di Cristo, Alexander G. Weil
Publikováno v:
Neurobiology of Disease, Vol 160, Iss , Pp 105535- (2021)
Background: Recent studies report infiltration of peripheral blood mononuclear cells (PBMCs) into the central nervous system (CNS) in epileptic disorders, suggestive of a potential contribution of PBMC extravasation to the generation of seizures. Nev
Externí odkaz:
https://doaj.org/article/4bdea1475d054ca59f21452b9df59894
Autor:
Daniele C. Wolf, Sébastien Desgent, Nathalie T. Sanon, Jia-Shu Chen, Lior M. Elkaim, Ciprian M. Bosoi, Patricia N. Awad, Alexe Simard, Muhammad T. Salam, Guillaume-Alexandre Bilodeau, Sandra Duss, Mohamad Sawan, Evan C. Lewis, Alexander G. Weil
Publikováno v:
Neurobiology of Disease, Vol 161, Iss , Pp 105546- (2021)
Febrile seizures (FS) are common, affecting 2–5% of children between the ages of 3 months and 6 years. Complex FS occur in 10% of patients with FS and are strongly associated with mesial temporal lobe epilepsy. Current research suggests that predis
Externí odkaz:
https://doaj.org/article/8731fe1d9396495487d22402c263a09b