Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Alexander G. Myasnikov"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The 26S proteasome is a protein degradation machine composed of a 20S core particle (CP) flanked at one or both ends by a 19S ATPase regulatory particle (RP). Here the authors reconstitute asymmetric archaeal proteasomes and reveal allosteric couplin
Externí odkaz:
https://doaj.org/article/30380c212df8404498d4bb7e427838f4
Autor:
Elena M. Maksimova, Alexey P. Korepanov, Olesya V. Kravchenko, Timur N. Baymukhametov, Alexander G. Myasnikov, Konstantin S. Vassilenko, Zhanna A. Afonina, Elena A. Stolboushkina
Publikováno v:
International Journal of Biomedicine, Vol 11, Iss Suppl_1, Pp 23-24 (2021)
Background: Ribosome biogenesis is a complicated multi-stage process. In the cell, 30S ribosomal subunit assembly is fast and efficient, proceeding with the help of numerous assembly protein factors. The exact role of most assembly factors and mechan
Externí odkaz:
https://doaj.org/article/c52af8f11e6942f7a6289987546b4025
Autor:
Grigory Sharov, Karine Voltz, Alexandre Durand, Olga Kolesnikova, Gabor Papai, Alexander G. Myasnikov, Annick Dejaegere, Adam Ben Shem, Patrick Schultz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
The transcription co-activator complex SAGA is recruited to promoters by transcriptional activators and promotes the formation of the pre-initiation complex. Here, the authors present the cryo-EM structure of the SAGA complex and resolve the major ta
Externí odkaz:
https://doaj.org/article/9840b937571446d3924b256fc336f3ee
Autor:
Elena M. Maksimova, Alexey P. Korepanov, Olesya V. Kravchenko, Timur N. Baymukhametov, Alexander G. Myasnikov, Konstantin S. Vassilenko, Zhanna A. Afonina, Elena A. Stolboushkina
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 6140 (2021)
Ribosome biogenesis is a highly coordinated and complex process that requires numerous assembly factors that ensure prompt and flawless maturation of ribosomal subunits. Despite the increasing amount of data collected, the exact role of most assembly
Externí odkaz:
https://doaj.org/article/ac7aa0198ad34feeb4370e72ded63c5a
Autor:
Alexander G. Myasnikov, S. Kundhavai Natchiar, Marielle Nebout, Isabelle Hazemann, Véronique Imbert, Heena Khatter, Jean-François Peyron, Bruno P. Klaholz
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
The ribosome of bacteria and other unicellular pathogens is a common target for antibiotic drugs. Here the authors determine a structure of the human ribosome bound to the translation inhibitor cycloheximide, and provide evidence that targeting the r
Externí odkaz:
https://doaj.org/article/5c015c0b3ce04e609d082a4c3d51b4f2
Autor:
Franck Martin, Jean-François Ménétret, Angelita Simonetti, Alexander G. Myasnikov, Quentin Vicens, Lydia Prongidi-Fix, S. Kundhavai Natchiar, Bruno P. Klaholz, Gilbert Eriani
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Prokaryotic translation initiation involves mRNA-ribosomal RNA base pairing interactions. Here, the authors provide evidence for a similar base pairing interactions occurring between the human h4 mRNA and helix 16 of the small subunit rRNA to positio
Externí odkaz:
https://doaj.org/article/13bf703b19f34a32b972880d5c0ed24e
Publikováno v:
Biomolecules, Vol 8, Iss 4, p 125 (2018)
Chemical modifications of RNA have recently gained new attention in biological sciences. They occur notably on messenger RNA (mRNA) and ribosomal RNA (rRNA) and are important for various cellular functions, but their molecular mechanism of action is
Externí odkaz:
https://doaj.org/article/24e8706a4f684455bf1ea7b76cc377e1
Autor:
Mikael Holm, S. Kundhavai Natchiar, Emily J. Rundlet, Alexander G. Myasnikov, Zoe L. Watson, Roger B. Altman, Hao-Yuan Wang, Jack Taunton, Scott C. Blanchard
Publikováno v:
Nature. 617:200-207
In all species, ribosomes synthesize proteins by faithfully decoding messenger RNA (mRNA) nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the decoding mechanism derives principally from studies on bacterial systems1. Althou
Autor:
Ray Yu-Ruei Wang, Chari M. Noddings, Elaine Kirschke, Alexander G. Myasnikov, Jill L. Johnson, David A. Agard
Publikováno v:
Nature
Maintaining a healthy proteome is fundamental for the survival of all organisms(1). Integral to this are Hsp90 and Hsp70, molecular chaperones that together facilitate the folding, remodelling and maturation of the many’client proteins’ of Hsp90(
Autor:
Hongtu Zhao, Alexander G. Myasnikov, Teresa M. Dunn, Sita D. Gupta, Chia-Hsueh Lee, Gongshe Han, Niranjanakumari Somashekarappa, Ravi C. Kalathur, Zhe Zhang, Kenneth Gable, Yingdi Wang, Yiming Niu
Publikováno v:
Nat Struct Mol Biol
Sphingolipids are essential lipids in eukaryotic membranes. In humans, the first and rate-limiting step of sphingolipid synthesis is catalyzed by the serine palmitoyltransferase holocomplex, which consists of catalytic components (SPTLC1 and SPTLC2)