Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Alexander G. Marneros"'
Autor:
Joseph O. Lamontagne, Hui Zhang, Alia M. Zeid, Karin Strittmatter, Alicia D. Rocha, Trevor Williams, Sheryl Zhang, Alexander G. Marneros
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
How the distal nephron is patterned during kidney development has been difficult to study. Here they show that AP-2β is required for the formation and postnatal function of distal convoluted tubules, whereas AP-2α has a role in maintaining the stru
Externí odkaz:
https://doaj.org/article/09580c4613c64e9d94e3ad0c783bf184
Autor:
Lizhi He, Jhih-Hua Jhong, Qi Chen, Kai-Yao Huang, Karin Strittmatter, Johannes Kreuzer, Michael DeRan, Xu Wu, Tzong-Yi Lee, Nikolai Slavov, Wilhelm Haas, Alexander G. Marneros
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109955- (2021)
Summary: Macrophages undergoing M1- versus M2-type polarization differ significantly in their cell metabolism and cellular functions. Here, global quantitative time-course proteomics and phosphoproteomics paired with transcriptomics provide a compreh
Externí odkaz:
https://doaj.org/article/f157ca1578fa466bb58ec28d74dce0d4
Autor:
Alexander G. Marneros
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108616- (2021)
Summary: Magnesium (Mg2+) homeostasis depends on active transcellular Mg2+ reuptake from urine in distal convoluted tubules (DCTs) via the Mg2+ channel TRPM6, whose activity has been proposed to be regulated by EGF. Calcium (Ca2+) homeostasis depends
Externí odkaz:
https://doaj.org/article/3b28a447b2574bdbad3f95c9afb206e2
Autor:
Alexander G. Marneros
Publikováno v:
Cell Reports, Vol 4, Iss 5, Pp 945-958 (2013)
The NLRP3 inflammasome is activated in age-related macular degeneration (AMD), but it remains unknown whether its activation contributes to AMD pathologies. VEGF-A is increased in neovascular (“wet”) AMD, but it is not known whether it plays a ro
Externí odkaz:
https://doaj.org/article/d882d9f1d2f74c80a8f22431c887d1ce
Autor:
Jakob Malsy, Andrea C Alvarado, Joseph O Lamontagne, Karin Strittmatter, Alexander G Marneros
Publikováno v:
eLife, Vol 9 (2020)
NLRP3 inflammasome activation and complement-mediated inflammation have been implicated in promoting choroidal neovascularization (CNV) in age-related macular degeneration (AMD), but central questions regarding their contributions to AMD pathogenesis
Externí odkaz:
https://doaj.org/article/e99e330bb6c54b80a21d14269dc1b98b
Increased VEGF‐A promotes multiple distinct aging diseases of the eye through shared pathomechanisms
Autor:
Alexander G Marneros
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 3, Pp 208-231 (2016)
Abstract While increased VEGF‐A has been associated with neovascular age‐related macular degeneration (AMD), it is not known whether VEGF‐A may also promote other age‐related eye diseases. Here, we show that an increase in VEGF‐A is suffici
Externí odkaz:
https://doaj.org/article/0449a96e380a4dfc8a1e73e202dc9844
Autor:
Alexander G. Marneros, Michael K. Yoon, Hillary R. Kelly, Diane G. Brackett, Suzanne K. Freitag, Miriam B Barshak
Publikováno v:
New England Journal of Medicine. 384:1553-1562
A Man with a Rash on the Scalp and Face A 78-year-old man was admitted with a forehead and scalp rash and eyelid edema on the left side. The rash spread to the right side, with lesions appearing as...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2435aafad9595f1e48f5ac7c29215590
https://doi.org/10.1056/nejmcpc2100276
https://doi.org/10.1056/nejmcpc2100276
Publikováno v:
FASEB J
Epidermal growth factor (EGF) is produced in the kidney by thick ascending limbs of the loop of Henle and by distal convoluted tubules (DCTs). Reduced urinary EGF levels have been associated with chronic kidney disease but it is not known whether phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455f092ffe376a6332f6dbb019418464
https://doi.org/10.1096/fj.202101837r
https://doi.org/10.1096/fj.202101837r
Autor:
Alexander G. Marneros
Publikováno v:
FEBS J
Current anti-VEGF-A therapies inhibit choroidal neovascularization (CNV) in a subset of patients with neovascular age-related macular degeneration (NV-AMD). However, long-term treatment with such anti-VEGF-A therapies may impair physiological functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4fbf5b3908498697491e06388e5c83
https://pubmed.ncbi.nlm.nih.gov/34767301
https://pubmed.ncbi.nlm.nih.gov/34767301
Autor:
Young H. Kwon, S. Scott Whitmore, Edwin M. Stone, Grefachew Workalemahu, Michael D. Abràmoff, Miles J. Flamme-Wiese, Robert F. Mullins, Alexander G. Marneros, Kai Wang, Erin A. Boese, Budd A. Tucker, Elliott H. Sohn
Publikováno v:
Am J Pathol
Early age-related macular degeneration (AMD) is characterized by degeneration of the choriocapillaris, the vascular supply of retinal photoreceptor cells. We assessed vascular loss during disease progression in the choriocapillaris and larger vessels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25bc5d9f7421891067fe52f326482478
https://doi.org/10.1016/j.ajpath.2019.04.005
https://doi.org/10.1016/j.ajpath.2019.04.005