Absolute Quantitative Targeted Monitoring of Potential Plasma Protein Biomarkers: A Pilot Study on Healthy Individuals

Autor: Alexey S. Kononikhin, Natalia L. Starodubtseva, Alexander G. Brzhozovskiy, Alisa O. Tokareva, Daria N. Kashirina, Natalia V. Zakharova, Anna E. Bugrova, Maria I. Indeykina, Liudmila Kh. Pastushkova, Irina M. Larina, Vladimir A. Mitkevich, Alexander A. Makarov, Evgeny N. Nikolaev

Publikováno v: Biomedicines, Vol 12, Iss 10, p 2403 (2024)

Background/Objectives: The development of blood tests for the early detection of individual predisposition to socially significant diseases remains a pressing issue. Methods: In this pilot study, multiple reaction monitoring mass spectrometry (MRM-MS

Externí odkaz: https://doaj.org/article/2a40bf520acd4d018a20eac60e822063

Integrating Proteomics and Lipidomics for Evaluating the Risk of Breast Cancer Progression: A Pilot Study

Autor: Natalia L. Starodubtseva, Alisa O. Tokareva, Valeriy V. Rodionov, Alexander G. Brzhozovskiy, Anna E. Bugrova, Vitaliy V. Chagovets, Vlada V. Kometova, Evgenii N. Kukaev, Nelson C. Soares, Grigoriy I. Kovalev, Alexey S. Kononikhin, Vladimir E. Frankevich, Evgeny N. Nikolaev, Gennady T. Sukhikh

Publikováno v: Biomedicines, Vol 11, Iss 7, p 1786 (2023)

Metastasis is a serious and often life-threatening condition, representing the leading cause of death among women with breast cancer (BC). Although the current clinical classification of BC is well-established, the addition of minimally invasive labo

Externí odkaz: https://doaj.org/article/3dcf8ab8750e461597ae801fe02f8154

Proteomic Characterization of Dry Blood Spots of Healthy Women During Simulation the Microgravity Effects Using Dry Immersion

Autor: Daria N. Kashirina, Alexander G. Brzhozovskiy, Wen Sun, Ludmila Kh. Pastushkova, Olga V. Popova, Vasiliy B. Rusanov, Evgeny N. Nikolaev, Irina M. Larina, Alexey S. Kononikhin

Publikováno v: Frontiers in Physiology, Vol 12 (2022)

Externí odkaz: https://doaj.org/article/45379b11e100459692cb8a27b0ef604c

miRNAs and Their Gene Targets—A Clue to Differentiate Pregnancies with Small for Gestational Age Newborns, Intrauterine Growth Restriction, and Preeclampsia

Autor: Angelika V. Timofeeva, Ivan S. Fedorov, Alexander G. Brzhozovskiy, Anna E. Bugrova, Vitaliy V. Chagovets, Maria V. Volochaeva, Natalia L. Starodubtseva, Vladimir E. Frankevich, Evgeny N. Nikolaev, Roman G. Shmakov, Gennady T. Sukhikh

Publikováno v: Diagnostics, Vol 11, Iss 4, p 729 (2021)

Despite the differences in the clinical manifestations of major obstetric syndromes, such as preeclampsia (PE) and intrauterine growth restriction (IUGR), their pathogenesis is based on the dysregulation of proliferation, differentiation, and invasio

Externí odkaz: https://doaj.org/article/964da871bfab4c108370afa03deb0595

The Dynamics of β-Amyloid Proteoforms Accumulation in the Brain of a 5xFAD Mouse Model of Alzheimer’s Disease

Autor: Anna E. Bugrova, Polina A. Strelnikova, Maria I. Indeykina, Alexey S. Kononikhin, Natalia V. Zakharova, Alexander G. Brzhozovskiy, Evgeny P. Barykin, Stanislav I. Pekov, Maria S. Gavrish, Alexey A. Babaev, Anna M. Kosyreva, Anna Y. Morozova, Daniil A. Degterev, Vladimir A. Mitkevich, Igor A. Popov, Alexander A. Makarov, Evgeny N. Nikolaev

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 27, p 27 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 27
International Journal of Molecular Sciences

Alzheimer’s disease (AD) is the leading cause of dementia among the elderly. Neuropathologically, AD is characterized by the deposition of a 39- to 42-amino acid long β-amyloid (Aβ) peptide in the form of senile plaques. Several post-translationa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffe475c8cb636396fca66e715c3f2c5
https://www.mdpi.com/1422-0067/23/1/27