Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Alexander G Fletcher"'
Autor:
Christian Cammarota, Nicole S Dawney, Philip M Bellomio, Maren Jüng, Alexander G Fletcher, Tara M Finegan, Dan T Bergstralh
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 4, p e1012001 (2024)
Epithelial tissues are the most abundant tissue type in animals, lining body cavities and generating compartment barriers. The function of a monolayered epithelial tissue-whether protective, secretory, absorptive, or filtrative-relies on the side-by-
Externí odkaz:
https://doaj.org/article/c4e1ec2af1c44925ac01768b342d6c4e
Autor:
Sandra Montes-Olivas, Danny Legge, Abbie Lund, Alexander G Fletcher, Ann C Williams, Lucia Marucci, Martin Homer
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 8, p e1011386 (2023)
Organoids offer a powerful model to study cellular self-organisation, the growth of specific tissue morphologies in-vitro, and to assess potential medical therapies. However, the intrinsic mechanisms of these systems are not entirely understood yet,
Externí odkaz:
https://doaj.org/article/bc64428b884d4479a8b56223f15161f1
Autor:
Alexander Nestor-Bergmann, Guy B Blanchard, Nathan Hervieux, Alexander G Fletcher, Jocelyn Étienne, Bénédicte Sanson
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 1, p e1009812 (2022)
Cell intercalation is a key cell behaviour of morphogenesis and wound healing, where local cell neighbour exchanges can cause dramatic tissue deformations such as body axis extension. Substantial experimental work has identified the key molecular pla
Externí odkaz:
https://doaj.org/article/81f438ab32524d5bb27422fc2d304c9a
Publikováno v:
eLife, Vol 10 (2021)
Bacteria inhibit and kill one another with a diverse array of compounds, including bacteriocins and antibiotics. These attacks are highly regulated, but we lack a clear understanding of the evolutionary logic underlying this regulation. Here, we comb
Externí odkaz:
https://doaj.org/article/10158f84fd7d40dbadb3350330b1b257
Autor:
Tara M Finegan, Nathan Hervieux, Alexander Nestor-Bergmann, Alexander G Fletcher, Guy B Blanchard, Bénédicte Sanson
Publikováno v:
PLoS Biology, Vol 17, Iss 12, p e3000522 (2019)
In epithelia, tricellular vertices are emerging as important sites for the regulation of epithelial integrity and function. Compared to bicellular contacts, however, much less is known. In particular, resident proteins at tricellular vertices were id
Externí odkaz:
https://doaj.org/article/56b7944966854d2db5beb4c880c2e140
Autor:
Oliver J Maclaren, Aimée Parker, Carmen Pin, Simon R Carding, Alastair J M Watson, Alexander G Fletcher, Helen M Byrne, Philip K Maini
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 7, p e1005688 (2017)
Our work addresses two key challenges, one biological and one methodological. First, we aim to understand how proliferation and cell migration rates in the intestinal epithelium are related under healthy, damaged (Ara-C treated) and recovering condit
Externí odkaz:
https://doaj.org/article/c51090bb4d624b438d20bf4f061ad52c
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 2, p e1005387 (2017)
The coordinated behaviour of populations of cells plays a central role in tissue growth and renewal. Cells react to their microenvironment by modulating processes such as movement, growth and proliferation, and signalling. Alongside experimental stud
Externí odkaz:
https://doaj.org/article/314e23be8a3946a9a3817c5eb1e1e26f
Publikováno v:
eLife, Vol 5 (2016)
Convergence and extension movements elongate tissues during development. Drosophila germ-band extension (GBE) is one example, which requires active cell rearrangements driven by Myosin II planar polarisation. Here, we develop novel computational meth
Externí odkaz:
https://doaj.org/article/b88c802c2f244fa188c9de67549c4e6f
Spatial Metrics of Tumour Vascular Organisation Predict Radiation Efficacy in a Computational Model.
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 1, p e1004712 (2016)
Intratumoural heterogeneity is known to contribute to poor therapeutic response. Variations in oxygen tension in particular have been correlated with changes in radiation response in vitro and at the clinical scale with overall survival. Heterogeneit
Externí odkaz:
https://doaj.org/article/5076b210985a4f40822e6c0ea5639281
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 12, p e1004679 (2015)
Embryogenesis is an extraordinarily robust process, exhibiting the ability to control tissue size and repair patterning defects in the face of environmental and genetic perturbations. The size and shape of a developing tissue is a function of the num
Externí odkaz:
https://doaj.org/article/01ae5eef01db4482a9e0ddf43154a441