Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Alexander G Bick"'
Autor:
Anurag Verma, Noah L Tsao, Lauren O Thomann, Yuk-Lam Ho, Sudha K Iyengar, Shiuh-Wen Luoh, Rotonya Carr, Dana C Crawford, Jimmy T Efird, Jennifer E Huffman, Adriana Hung, Kerry L Ivey, Michael G Levin, Julie Lynch, Pradeep Natarajan, Saiju Pyarajan, Alexander G Bick, Lauren Costa, Giulio Genovese, Richard Hauger, Ravi Madduri, Gita A Pathak, Renato Polimanti, Benjamin Voight, Marijana Vujkovic, Seyedeh Maryam Zekavat, Hongyu Zhao, Marylyn D Ritchie, VA Million Veteran Program COVID-19 Science Initiative, Kyong-Mi Chang, Kelly Cho, Juan P Casas, Philip S Tsao, J Michael Gaziano, Christopher O'Donnell, Scott M Damrauer, Katherine P Liao
Publikováno v:
PLoS Genetics, Vol 18, Iss 4, p e1010113 (2022)
The study aims to determine the shared genetic architecture between COVID-19 severity with existing medical conditions using electronic health record (EHR) data. We conducted a Phenome-Wide Association Study (PheWAS) of genetic variants associated wi
Externí odkaz:
https://doaj.org/article/ffdb9e4bf94d4c729a4428cb28eaf0c9
Autor:
Ulrike Esslinger, Sophie Garnier, Agathe Korniat, Carole Proust, Georgios Kararigas, Martina Müller-Nurasyid, Jean-Philippe Empana, Michael P Morley, Claire Perret, Klaus Stark, Alexander G Bick, Sanjay K Prasad, Jennifer Kriebel, Jin Li, Laurence Tiret, Konstantin Strauch, Declan P O'Regan, Kenneth B Marguiles, Jonathan G Seidman, Pierre Boutouyrie, Patrick Lacolley, Xavier Jouven, Christian Hengstenberg, Michel Komajda, Hakon Hakonarson, Richard Isnard, Eloisa Arbustini, Harald Grallert, Stuart A Cook, Christine E Seidman, Vera Regitz-Zagrosek, Thomas P Cappola, Philippe Charron, François Cambien, Eric Villard
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229472 (2020)
[This corrects the article DOI: 10.1371/journal.pone.0172995.].
Externí odkaz:
https://doaj.org/article/8972f4d73bdb419c948a6bd6736188a5
Autor:
Md Mesbah Uddin, Seyedmohammad Saadatagah, Abhishek Niroula, Bing Yu, Whitney E. Hornsby, Shriienidhie Ganesh, Kim Lannery, Art Schuermans, Michael C. Honigberg, Alexander G. Bick, Peter Libby, Benjamin L. Ebert, Christie M. Ballantyne, Pradeep Natarajan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Clonal hematopoiesis of indeterminate potential (CHIP) is linked to diverse aging-related diseases, including hematologic malignancy and atherosclerotic cardiovascular disease (ASCVD). While CHIP is common among older adults, the underlying
Externí odkaz:
https://doaj.org/article/a84fedff581f4998bacccb1b7ef8aab7
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract T-cells play a critical role in multiple aspects of human health and disease. However, to date the genetic determinants of human T-cell abundance have not been studied at scale because assays quantifying T-cell abundance are not widely used
Externí odkaz:
https://doaj.org/article/8233ecb9947c464eb85a3b85ea6e22ad
Autor:
Ulrike Esslinger, Sophie Garnier, Agathe Korniat, Carole Proust, Georgios Kararigas, Martina Müller-Nurasyid, Jean-Philippe Empana, Michael P Morley, Claire Perret, Klaus Stark, Alexander G Bick, Sanjay K Prasad, Jennifer Kriebel, Jin Li, Laurence Tiret, Konstantin Strauch, Declan P O'Regan, Kenneth B Marguiles, Jonathan G Seidman, Pierre Boutouyrie, Patrick Lacolley, Xavier Jouven, Christian Hengstenberg, Michel Komajda, Hakon Hakonarson, Richard Isnard, Eloisa Arbustini, Harald Grallert, Stuart A Cook, Christine E Seidman, Vera Regitz-Zagrosek, Thomas P Cappola, Philippe Charron, François Cambien, Eric Villard
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172995 (2017)
AimsDilated cardiomyopathy (DCM) is an important cause of heart failure with a strong familial component. We performed an exome-wide array-based association study (EWAS) to assess the contribution of missense variants to sporadic DCM.Methods and resu
Externí odkaz:
https://doaj.org/article/57cc136b5b6b488385fb35ea7dfd896e
Autor:
Yash Pershad, Taralynn Mack, Hannah Poisner, Yasminka A. Jakubek, Adrienne M. Stilp, Braxton D. Mitchell, Joshua P. Lewis, Eric Boerwinkle, Ruth J. F. Loos, Nathalie Chami, Zhe Wang, Kathleen Barnes, Nathan Pankratz, Myriam Fornage, Susan Redline, Bruce M. Psaty, Joshua C. Bis, Ali Shojaie, Edwin K. Silverman, Michael H. Cho, Jeong H. Yun, Dawn DeMeo, Daniel Levy, Andrew D. Johnson, Rasika A. Mathias, Margaret A. Taub, Donna Arnett, Kari E. North, Laura M. Raffield, April P. Carson, Margaret F. Doyle, Stephen S. Rich, Jerome I. Rotter, Xiuqing Guo, Nancy J. Cox, Dan M. Roden, Nora Franceschini, Pinkal Desai, Alex P. Reiner, Paul L. Auer, Paul A. Scheet, Siddhartha Jaiswal, Joshua S. Weinstock, Alexander G. Bick
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger st
Externí odkaz:
https://doaj.org/article/1250c0a2d37c41cbad1c671a34d1b82b
Driver mutation zygosity is a critical factor in predicting clonal hematopoiesis transformation risk
Autor:
Ashwin Kishtagari, M. A. Wasay Khan, Yajing Li, Caitlyn Vlasschaert, Naimisha Marneni, Alexander J. Silver, Kelly von Beck, Travis Spaulding, Shannon Stockton, Christina Snider, Andrew Sochacki, Dixon Dorand, Taralynn M. Mack, P. Brent Ferrell, Yaomin Xu, Cosmin A. Bejan, Michael R. Savona, Alexander G. Bick
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-6 (2024)
Abstract Clonal hematopoiesis (CH) can be caused by either single gene mutations (eg point mutations in JAK2 causing CHIP) or mosaic chromosomal alterations (e.g., loss of heterozygosity at chromosome 9p). CH is associated with a significantly increa
Externí odkaz:
https://doaj.org/article/8eae0d4d2063482883822364b8d4b942
Autor:
M.A. Wasay Khan, Alexander G. Bick
Publikováno v:
Haematologica, Vol 107, Iss 8 (2021)
Externí odkaz:
https://doaj.org/article/6bac38bd136f4b528396327fb3f617c1
Autor:
Christopher J. Gibson, Geoffrey Fell, Tal Sella, Adam S. Sperling, Craig Snow, Shoshana M. Rosenberg, Greg Kirkner, Ashka Patel, Deborah Dillon, Alexander G. Bick, Donna Neuberg, Ann H. Partridge, Peter G. Miller
Publikováno v:
Clinical Cancer Research. :OF1-OF8
Background: Young women treated for breast cancer with cytotoxic therapies are at risk for clonal hematopoiesis of indeterminate potential (CHIP), a condition in which blood cells carrying a somatic mutation associated with hematologic malignancy com
Autor:
Esra D. Gumuser, Art Schuermans, So Mi Jemma Cho, Zachary A. Sporn, Md Mesbah Uddin, Kaavya Paruchuri, Tetsushi Nakao, Zhi Yu, Sara Haidermota, Whitney Hornsby, Lachelle D. Weeks, Abhishek Niroula, Siddhartha Jaiswal, Peter Libby, Benjamin L. Ebert, Alexander G. Bick, Pradeep Natarajan, Michael C. Honigberg
Publikováno v:
J Am Coll Cardiol
BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP)–the age-related clonal expansion of blood stem cells with leukemia-associated mutations–is a novel cardiovascular risk factor. Whether CHIP remains prognostic in individuals with