Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Alexander G, Tonevitsky"'
Publikováno v:
Toxins, Vol 16, Iss 6, p 248 (2024)
α-Latrotoxin (α-LTX) was found to form two-dimensional (2D) monolayer arrays in solution at relatively low concentrations (0.1 mg/mL), with the toxin tetramer constituting a unit cell. The crystals were imaged using cryogenic electron microscopy (c
Externí odkaz:
https://doaj.org/article/811db7b37d7441be8e8fab2b656efc0d
Autor:
Pierre Sabatier, Christian M. Beusch, Amir A. Saei, Mike Aoun, Noah Moruzzi, Ana Coelho, Niels Leijten, Magnus Nordenskjöld, Patrick Micke, Diana Maltseva, Alexander G. Tonevitsky, Vincent Millischer, J. Carlos Villaescusa, Sandeep Kadekar, Massimiliano Gaetani, Kamilya Altynbekova, Alexander Kel, Per-Olof Berggren, Oscar Simonson, Karl-Henrik Grinnemo, Rikard Holmdahl, Sergey Rodin, Roman A. Zubarev
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
To characterize molecular changes during cell type transitions, the authors develop a method to simultaneously measure protein expression and thermal stability changes. They apply this approach to study differences between human pluripotent stem cell
Externí odkaz:
https://doaj.org/article/ea00b3040ab748c68e25909b2a8c2546
Autor:
Xuemei Zhong, Guoqing Wang, Fu Li, Sixian Fang, Siai Zhou, Akihiro Ishiwata, Alexander G. Tonevitsky, Maxim Shkurnikov, Hui Cai, Feiqing Ding
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1615 (2023)
β-glucan, one of the homopolysaccharides composed of D-glucose, exists widely in cereals and microorganisms and possesses various biological activities, including anti-inflammatory, antioxidant, and anti-tumor properties. More recently, there has be
Externí odkaz:
https://doaj.org/article/bf846677193d41028d26f24326baa142
Autor:
Andrey A. Poloznikov, Stepan A. Nersisyan, Dmitry M. Hushpulian, Eliot H. Kazakov, Alexander G. Tonevitsky, Sergey V. Kazakov, Valery I. Vechorko, Sergey V. Nikulin, Julia A. Makarova, Irina G. Gazaryan
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
The review analyzes the potential advantages and problems associated with using HIF prolyl hydroxylase inhibitors as a treatment for COVID-19. HIF prolyl hydroxylase inhibitors are known to boost endogenous erythropoietin (Epo) and activate erythropo
Externí odkaz:
https://doaj.org/article/861906911e074ab98b8dd5ba057316b3
Autor:
Vladimir V. Galatenko, Diana V. Maltseva, Alexey V. Galatenko, Sergey Rodin, Alexander G. Tonevitsky
Publikováno v:
BMC Medical Genomics, Vol 11, Iss S1, Pp 77-81 (2018)
Abstract Background Laminins are a major family of extracellular matrix proteins and the main component of basement membranes. Laminins are involved in many if not all stages of cancer progression, and expression of laminin genes has prognostic value
Externí odkaz:
https://doaj.org/article/1cdc0423efc6400a9cb3511a4d2fbe4c
Autor:
Alexander S. Paramonov, Ekaterina N. Lyukmanova, Alexander G. Tonevitsky, Alexander S. Arseniev, Zakhar O. Shenkarev
Publikováno v:
Biochemical and Biophysical Research Communications. 585:22-28
Thionins are the family of small (∼5 kDa) cationic cysteine-rich peptides involved in the immune response in plants. Viscotoxin A3 (VtA3) is the thionin from mistletoe (Viscum album) demonstrating antimicrobial and cytotoxic activity against cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765d2befb0a2ab0b3b6e78763bb6d971
https://doi.org/10.1016/j.bbrc.2021.11.022
https://doi.org/10.1016/j.bbrc.2021.11.022
Autor:
Nickolai V Vysokov, John-Paul Silva, Vera G Lelianova, Jason Suckling, John Cassidy, Jennifer K Blackburn, Natalia Yankova, Mustafa BA Djamgoz, Serguei V Kozlov, Alexander G Tonevitsky, Yuri A Ushkaryov
Publikováno v:
eLife, Vol 7 (2018)
A presynaptic adhesion G-protein-coupled receptor, latrophilin-1, and a postsynaptic transmembrane protein, Lasso/teneurin-2, are implicated in trans-synaptic interaction that contributes to synapse formation. Surprisingly, during neuronal developmen
Externí odkaz:
https://doaj.org/article/e3ab38e5ab3145c8b2d8316c81bfd8a3
Autor:
Ann-Kathrin Ernst, Annika Putscher, Timur R Samatov, Anna Suling, Vladimir V Galatenko, Maxim Yu Shkurnikov, Evgeny N Knyazev, Alexander G Tonevitsky, Thomas Haalck, Tobias Lange, Hanna Maar, Jennifer Schröder-Schwarz, Kristoffer Riecken, Udo Schumacher, Daniel Wicklein
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192525 (2018)
Finding additional functional targets for combination therapy could improve the outcome for melanoma patients. In a spontaneous metastasis xenograft model of human melanoma a shRNA mediated knockdown of L1CAM more than sevenfold reduced the number of
Externí odkaz:
https://doaj.org/article/35f4bb6c08f24b1ea2f9c87854f2c513
Autor:
Stepan Nersisyan, Sabrina Arnold, Alexander G. Tonevitsky, Christine Stürken, Susanne Lezius, Udo Schumacher, Timur R. Samatov, D. V. Maltseva, Jan Kortland, Daniel Wicklein, Karin Milde-Langosch
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 148:1525-1542
PurposeThe transcription factor Fra-2 affects the invasive potential of breast cancer cells by dysregulating adhesion molecules in vitro. Previous results suggested that it upregulates the expression of E- and P-selectin ligands. Such selectin ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09586e4f8cdc28cb9fc76b952300f8c7
https://doi.org/10.1007/s00432-021-03812-2
https://doi.org/10.1007/s00432-021-03812-2
Publikováno v:
Trends in Biochemical Sciences. 46:640-651
miRNAs are short RNA molecules regulating multiple cellular processes through post-transcriptional gene silencing. Over the past decade, miRNAs have been found in the extracellular space and have been consistently shown to mediate functional communic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f46bc398cce64329a0a93e6f3adc7e
https://doi.org/10.1016/j.tibs.2021.01.007
https://doi.org/10.1016/j.tibs.2021.01.007