Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Alexander G, Robling"'
Autor:
Aina He, Songhai Tian, Oded Kopper, Daniel J Horan, Peng Chen, Roderick T Bronson, Ren Sheng, Hao Wu, Lufei Sui, Kun Zhou, Liang Tao, Quan Wu, Yujing Huang, Zan Shen, Sen Han, Xueqing Chen, Hong Chen, Xi He, Alexander G Robling, Rongsheng Jin, Hans Clevers, Dongxi Xiang, Zhe Li, Min Dong
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002353 (2023)
Wnt signaling pathways are transmitted via 10 homologous frizzled receptors (FZD1-10) in humans. Reagents broadly inhibiting Wnt signaling pathways reduce growth and metastasis of many tumors, but their therapeutic development has been hampered by th
Externí odkaz:
https://doaj.org/article/c1f3079f1d4342a0a3d6ba9ffe231f87
Autor:
Matt Prideaux, Alberto Smargiassi, Gang Peng, Marco Brotto, Alexander G Robling, Lynda F Bonewald
Publikováno v:
JBMR Plus, Vol 7, Iss 6, Pp n/a-n/a (2023)
ABSTRACT The L‐enantiomer of β‐aminoisobutyric acid (BAIBA) is secreted by contracted muscle in mice, and exercise increases serum levels in humans. In mice, L‐BAIBA reduces bone loss with unloading, but whether it can have a positive effect w
Externí odkaz:
https://doaj.org/article/d0dfca7e0abd44d88acc13980d9fa125
Autor:
Rafiou Agoro, Intawat Nookaew, Megan L. Noonan, Yamil G. Marambio, Sheng Liu, Wennan Chang, Hongyu Gao, Lainey M. Hibbard, Corinne E. Metzger, Daniel Horan, William R. Thompson, Xiaoling Xuei, Yunlong Liu, Chi Zhang, Alexander G. Robling, Lynda F. Bonewald, Jun Wan, Kenneth E. White
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionDue to a lack of spatial-temporal resolution at the single cell level, the etiologies of the bone dysfunction caused by diseases such as normal aging, osteoporosis, and the metabolic bone disease associated with chronic kidney disease (CK
Externí odkaz:
https://doaj.org/article/80c1a0d4f60f4299bc60171040e9f822
Autor:
Perla C. Reyes Fernandez, Christian S. Wright, Adrianna N. Masterson, Xin Yi, Tristen V. Tellman, Andrei Bonteanu, Katie Rust, Megan L. Noonan, Kenneth E. White, Karl J. Lewis, Uma Sankar, Julia M. Hum, Gregory Bix, Danielle Wu, Alexander G. Robling, Rajesh Sardar, Mary C. Farach-Carson, William R. Thompson
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1857 (2022)
Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified “tethering elements” (TEs) spanning the pericellular space of osteocytes and transmitting mechanical
Externí odkaz:
https://doaj.org/article/a1392b417754406fb1656b6685dd4912
Autor:
Whitney A. Bullock, April M. Hoggatt, Daniel J. Horan, Andrew J. Elmendorf, Amy Y. Sato, Teresita Bellido, Gabriela G. Loots, Fredrick M. Pavalko, Alexander G. Robling
Publikováno v:
iScience, Vol 20, Iss , Pp 205-215 (2019)
Summary: Wnt signaling plays a key role in regulating bone remodeling. In vitro studies suggest that sclerostin's inhibitory action on Lrp5 is facilitated by the membrane-associated receptor Lrp4. We generated an Lrp4 R1170W knockin mouse model (Lrp4
Externí odkaz:
https://doaj.org/article/f7f843d78c6348eabf7967aba03f1a68
Autor:
Roy B Choi, Whitney A Bullock, April M Hoggatt, Gabriela G Loots, Damian C Genetos, Alexander G Robling
Publikováno v:
JBMR Plus, Vol 5, Iss 5, Pp n/a-n/a (2021)
ABSTRACT Sclerostin antibody (romosozumab) was recently approved for clinical use in the United States to treat osteoporosis. We and others have explored Wnt‐based combination therapy to disproportionately improve the anabolic effects of sclerostin
Externí odkaz:
https://doaj.org/article/8bf70de22fa94fbbae843dd1f34ce38c
Autor:
Roy B. Choi, April M. Hoggatt, Daniel J. Horan, Emily Z. Rogers, Gabriela G. Loots, Alexander G. Robling
Publikováno v:
Journal of Bone and Mineral Research. 38:765-774
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::444e49580c18ca17a11da329aa76be98
https://doi.org/10.1002/jbmr.4798
https://doi.org/10.1002/jbmr.4798
The mTORC2 Component Rictor Is Required for Load‐Induced Bone Formation in Late‐Stage Skeletal Cells
Autor:
Karl J Lewis, Xin Yi, Christian S Wright, Emily Z Pemberton, Whitney A Bullock, William R Thompson, Alexander G Robling
Publikováno v:
JBMR Plus, Vol 4, Iss 7, Pp n/a-n/a (2020)
ABSTRACT Bone relies on mechanical cues to build and maintain tissue composition and architecture. Our understanding of bone cell mechanotransduction continues to evolve, with a few key signaling pathways emerging as vital. Wnt/β‐catenin, for exam
Externí odkaz:
https://doaj.org/article/6299d5d7b70041cf8a6f6af606efa486
Autor:
Cassandra R Diegel, Steven Hann, Ugur M Ayturk, Jennifer C W Hu, Kyung-Eun Lim, Casey J Droscha, Zachary B Madaj, Gabrielle E Foxa, Isaac Izaguirre, VAI Vivarium and Transgenics Core, Alexander G Robling, Matthew L Warman, Bart O Williams
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008940 (2020)
Externí odkaz:
https://doaj.org/article/bffc7ee3d83b474a851167a2e1c5ff8b
Autor:
Cassandra R Diegel, Steven Hann, Ugur M Ayturk, Jennifer C W Hu, Kyung-Eun Lim, Casey J Droscha, Zachary B Madaj, Gabrielle E Foxa, Isaac Izaguirre, Vai Vivarium And Transgenics Core, Noorulain Paracha, Bohdan Pidhaynyy, Terry L Dowd, Alexander G Robling, Matthew L Warman, Bart O Williams
Publikováno v:
PLoS Genetics, Vol 16, Iss 5, p e1008361 (2020)
Osteocalcin (OCN), the most abundant noncollagenous protein in the bone matrix, is reported to be a bone-derived endocrine hormone with wide-ranging effects on many aspects of physiology, including glucose metabolism and male fertility. Many of these
Externí odkaz:
https://doaj.org/article/ca11b9a7b5bf43ddac9209d96f14f31a