Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Alexander Fuhrmann"'
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102424 (2014)
Single-molecule experiments indicate that integrin affinity is cation-type-dependent, but in spread cells integrins are engaged in complex focal adhesions (FAs), which can also regulate affinity. To better understand cation-type-dependent adhesion in
Externí odkaz:
https://doaj.org/article/f4836c5d7aea4f48af9ee1c7870eb55e
Autor:
Yu Suk Choi, Ludovic G. Vincent, Alexander Fuhrmann, Hermes Taylor-Weiner, Shaochen Chen, Jessica H. Wen, Kolin C. Hribar, Adam J. Engler
Publikováno v:
Nature materials
Stem cells regulate their fate by binding to, and contracting against, the extracellular matrix. Recently, it has been proposed that in addition to matrix stiffness and ligand type, the degree of coupling of fibrous protein to the surface of the unde
Publikováno v:
Biomaterials Surface Science
Cells have the amazing ability not only to sense how stiff their surrounding is but also to physically respond to changes in stiffness. Examples of this cellular response include migration following a stiffness gradient [1–3] and differentiation to
Publikováno v:
Fuhrmann, A; Banisadr, A; Beri, P; Tlsty, TD; & Engler, AJ. (2017). Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength. BIOPHYSICAL JOURNAL, 112(4), 736-745. doi: 10.1016/j.bpj.2016.12.038. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/9qh2p3sg
Biophysical journal, vol 112, iss 4
Biophysical journal, vol 112, iss 4
Cancer cells within a tumor are heterogeneous and only a small fraction are able to form secondary tumors. Universal biological markers that clearly identify potentially metastatic cells are limited, which complicates isolation and further study. How
Autor:
Zongming Fu, Jeremy Tuler, Vidya Venkatraman, Jennifer E. Van Eyk, Alexander Fuhrmann, Edward G. Lakatta, Mingyi Wang, Adriana S. Trujillo, Adam J. Engler, Rolf Bodmer, Alice Spenlehauer, Ayla O Sessions, Karen Ocorr, Anthony Cammarato, Gaurav Kaushik, Danielle Pohl, Sanford I. Bernstein
Publikováno v:
Circulation Research. 119
The human heart is capable of functioning for decades despite minimal cell turnover or regeneration, suggesting that molecular alterations help sustain heart function with age. However, identification of compensatory remodeling events in the aging he
Autor:
Alexander C. Zambon, Adam J. Engler, Alexander Fuhrmann, Anthony Cammarato, Rolf Bodmer, Gaurav Kaushik, Sanford I. Bernstein
Publikováno v:
Journal of Cellular and Molecular Medicine
Aging is marked by a decline in LV diastolic function, which encompasses abnormalities in diastolic relaxation, chamber filling and/or passive myocardial stiffness. Genetic tractability and short life span make Drosophila melanogaster an ideal organi
Autor:
Adah Almutairi, Alexander Fuhrmann, Jerome V. Karpiak, Jessica H. Wen, Hermes Taylor-Weiner, Onkiu Choi, Adam J. Engler
Publikováno v:
Cellular and molecular bioengineering. 8(4)
Motile cells navigate through tissue by relying on tactile cues from gradients provided by extracellular matrix (ECM) such as ligand density or stiffness. Mesenchymal stem cells (MSCs) and fibroblasts encounter adhesive or ‘haptotactic’ gradients
Autor:
Stanislav P. Oshkadyerov, Tatiana P. Ugarova, Ivan S. Yermolenko, Valeryi K. Lishko, Robert Ros, Alexander Fuhrmann, Sergei Magonov
Publikováno v:
Langmuir. 26:17269-17277
The deposition of a multilayered fibrinogen matrix on various surfaces results in a dramatic reduction of integrin-mediated cell adhesion and outside-in signaling in platelets and leukocytes. The conversion of a highly adhesive, low-density fibrinoge
Autor:
Dario Anselmetti, Alexander Fuhrmann, Anke Becker, Frank Wilco Bartels, Matthew McIntosh, Patrik Plattner, Christoph Metzendorf, Norbert Sewald, Robert Ros
Publikováno v:
Biophysical Journal. 92(12):4391-4400
Intercellular communication by means of small signal molecules coordinates gene expression among bacteria. This population density-dependent regulation is known as quorum sensing. The symbiotic nitrogen-fixing bacterium Sinorhizobium meliloti Rm1021
Autor:
Alexander Fuhrmann
Dynamic single-molecule force spectroscopy is often used to distort bonds. The resulting responses, in the form of rupture forces, work applied, and trajectories of displacements, are used to reconstruct bond potentials. Such approaches often rely on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57cf2c16f55463abb01a78a2ad38a22
https://europepmc.org/articles/PMC4564686/
https://europepmc.org/articles/PMC4564686/