Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexander F.A. Keszei"'
Autor:
Apurva A. Govande, Sichen Shao, Rotem Sorek, Alexander F.A. Keszei, Gal Ofir, Adi Millman, B.R. Morehouse, Philip J. Kranzusch, B. Lowey
Publikováno v:
Nature
Stimulator of interferon genes (STING) is a receptor in human cells that senses foreign cyclic dinucleotides that are released during bacterial infection and in endogenous cyclic GMP-AMP signalling during viral infection and anti-tumour immunity1-5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2890a005c85eec007fce74149cee4e62
http://europepmc.org/articles/PMC7572726
http://europepmc.org/articles/PMC7572726
Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation
Autor:
Jason Murray, Brian B. Liau, Sichen Shao, Yumi Koga, Yongho Park, Eileen M Hoang, Alexander F.A. Keszei
Publikováno v:
J Am Chem Soc
Employed for over half a century to study protein synthesis, cycloheximide (CHX, 1) is a small molecule natural product that reversibly inhibits translation elongation. More recently, CHX has been applied to ribosome profiling, a method for mapping r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d1e2aed01a92ff958bddfd9ac70104
https://europepmc.org/articles/PMC9482341/
https://europepmc.org/articles/PMC9482341/
Autor:
Matthew C.J. Yip, Qing Feng, Michael J. McKenna, Sichen Shao, Vincent Chu, Alexander F.A. Keszei
Publikováno v:
Nature Structural & Molecular Biology. 26:343-349
Aberrantly stalled ribosomes initiate the ribosome-associated quality control (RQC) and mRNA surveillance pathways for the degradation of potentially toxic peptides and faulty mRNAs. During RQC, ANKZF1 (yeast Vms1p) releases ubiquitinated nascent pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5612d77d1e26f5c273d6ff40b956c75b
https://doi.org/10.1038/s41594-019-0211-4
https://doi.org/10.1038/s41594-019-0211-4
Autor:
Sadie P. Antine, Amy S. Lee, Ian T. Mathews, B. Lowey, Mohit Jain, Victor J. Cabrera, John J. Mekalanos, Alexander F.A. Keszei, Frank Schwede, Aaron T. Whiteley, Sichen Shao, B.R. Morehouse, Percy Niemann, Dmitry Kashin, Philip J. Kranzusch
Publikováno v:
Cell. 182(1)
cGAS/DncV-like nucleotidyltransferase (CD-NTase) enzymes are immune sensors that synthesize nucleotide second messengers and initiate antiviral responses in bacterial and animal cells. Here, we discover Enterobacter cloacae CD-NTase-associated protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8ab97e1d92ad665006d37beb0a54fa
https://pubmed.ncbi.nlm.nih.gov/32649879
https://pubmed.ncbi.nlm.nih.gov/32649879
Autor:
Alexander F.A. Keszei, Carmel Avraham, Tevie Mehlman, B.R. Morehouse, Avigail Stokar-Avihail, Sichen Shao, Taya Fedorenko, Erez Yirmiya, Adi Millman, Rotem Sorek, Yaara Oppenheimer-Shaanan, Philip J. Kranzusch, Gil Amitai, Nitzan Tal, Alexander Brandis, Ehud Herbst
Publikováno v:
Cell
The cyclic pyrimidines 3',5'-cyclic cytidine monophosphate (cCMP) and 3',5'-cyclic uridine monophosphate (cUMP) have been reported in multiple organisms and cell types. As opposed to the cyclic nucleotides 3',5'-cyclic adenosine monophosphate (cAMP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::978c7331714ea37ca279c08e98502157
https://doi.org/10.1038/s41579-021-00658-w
https://doi.org/10.1038/s41579-021-00658-w
Autor:
Alexander F.A. Keszei, Pankaj Garg, Frank Sicheri, Sachdev S. Sidhu, Derek F. Ceccarelli, Igor Kurinov
Publikováno v:
J Mol Biol
Ubiquitin-conjugating E2 enzymes are central to the ubiquitination cascade and have been implicated in cancer and other diseases. Despite strong interest in developing specific E2 inhibitors, the shallow and exposed active site has proven recalcitran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a25031e816365e22dc4ed085e523c7b
https://pubmed.ncbi.nlm.nih.gov/31634471
https://pubmed.ncbi.nlm.nih.gov/31634471
Autor:
Frank Sicheri, Alexander F.A. Keszei
IpaH enzymes are secreted bacterial effectors that function within host cells as E3 ubiquitin (Ub) ligases. Catalytic activity is imparted by a conserved novel E3 ligase (NEL) domain that is unique to Gram-negative pathogens and whose activity is rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0798b134653a7d22c9c49be7c7a24c7c
https://europepmc.org/articles/PMC5307447/
https://europepmc.org/articles/PMC5307447/
Autor:
Xiaojing Tang, Mike Tyers, Craig McCormick, Elton Zeqiraj, Alexander F.A. Keszei, Frank Sicheri, John R. Rohde
Publikováno v:
Molecular and Cellular Biology. 34:362-373
IpaH proteins are bacterium-specific E3 enzymes that function as type three secretion system (T3SS) effectors in Salmonella, Shigella, and other Gram-negative bacteria. IpaH enzymes recruit host substrates for ubiquitination via a leucine-rich repeat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd89531639f31568566d78a8bd1d158
https://doi.org/10.1128/mcb.01360-13
https://doi.org/10.1128/mcb.01360-13
Publikováno v:
The Journal of biological chemistry. 287(1)
The IpaH family of novel E3 ligase (NEL) enzymes occur in a variety of pathogenic and commensal bacteria that interact with eukaryotic hosts. We demonstrate that the leucine-rich repeat (LRR) substrate recognition domains of different IpaH enzymes au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b21ab1e5d91825cd5ee987e20723828
https://pubmed.ncbi.nlm.nih.gov/22065585
https://pubmed.ncbi.nlm.nih.gov/22065585