Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexander F. Shaffer"'
Autor:
John Robert Springer, Gina M. Jerome, Hayes Michael J, Michael T. Baratta, Daniel P. Walker, Graciela B. Arhancet, Alexander F. Shaffer, Jaime L. Masferrer, Ben S. Zweifel, Steven E. Heasley, Darin E. Jones, William M. Moore, Jeffrey S. Carter, Yvette M. Fobian, Michael L. Vazquez, Sue Metz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1114-1119
Inhibition of mPGES-1, the terminal enzyme in the arachidonic acid/COX pathway to regulate the production of pro-inflammatory prostaglandin PGE2, is considered an attractive new therapeutic target for safe and effective anti-inflammatory drugs. The d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b121fd58b89ecf308dd263c517c877ef
https://doi.org/10.1016/j.bmcl.2012.11.109
https://doi.org/10.1016/j.bmcl.2012.11.109
Autor:
Daniel P. Walker, Alexander F. Shaffer, William M. Moore, Michael T. Baratta, Sue Metz, Jeffrey A. Scholten, John Robert Springer, Jeffrey S. Carter, Hwang-Fun Lu, Steven E. Heasley, Yvette M. Fobian, Natasha M. Kablaoui, Francisco M. Franco, Li Xing, Shengtian Yang, Hanau Cathleen E, Michael L. Vazquez, Graciela B. Arhancet, Gina M. Jerome
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1120-1126
Microsomal prostaglandin E(2) synthase-1 (mPGES-1) is a novel therapeutic target for the treatment of inflammation and pain. In the preceding letter, we detailed the discovery of clinical candidate PF-04693627, a potent mPGES-1 inhibitor possessing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d05bf0698be13f2291735a95c4465f
https://doi.org/10.1016/j.bmcl.2012.11.107
https://doi.org/10.1016/j.bmcl.2012.11.107
Autor:
Stephen J. Mnich, Olga V. Nemirovskiy, James K. Gierse, Gabriel Mbalaviele, Adele M. Pauley, Alexander F. Shaffer, William M. Moore, Sumathy Mathialagan, Ben S. Zweifel, Jeffrey S. Carter, Jaime L. Masferrer, Michael L. Vazquez, Jane L. Wang
Publikováno v:
Biochemical Pharmacology. 79:1445-1454
Inflammation-induced microsomal prostaglandin E synthase-1 (mPGES-1) is the terminal enzyme that synthesizes prostaglandin E(2) (PGE(2)) downstream of cyclooxygenase-2 (COX-2). The efficacy of nonsteroidal anti-inflammatory drugs and COX-2 inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f2b47310c2ae7d1f319e11e57535cc
https://doi.org/10.1016/j.bcp.2010.01.003
https://doi.org/10.1016/j.bcp.2010.01.003
Autor:
Julia A. Guzova, Gabriel Mbalaviele, Alexander F. Shaffer, Sheri L. Bonar, John F. Schindler, David C. Thompson, Nandini Kishore, Catherine S. Tripp, Cynthia D. Sommers, Yiding Hu, Sumathy Mathialagan, Po Chang Chiang, Michele A. Melton, Lori Christine
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 329:14-25
Nuclear factor (NF)-kappaB activation has been clearly linked to the pathogenesis of multiple inflammatory diseases including arthritis. The central role that IkappaB kinase-2 (IKK-2) plays in regulating NF-kappaB signaling in response to inflammator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88dfc2562c02b4aed4c1440b261119e
https://doi.org/10.1124/jpet.108.143800
https://doi.org/10.1124/jpet.108.143800
Publikováno v:
Inflammation. 18:187-192
Several lines of evidence document a critical role for mast cells in immune complex-mediated inflammatory models. However, their role in nonimmune models of acute inflammation is largely unknown. In the present investigation, the role of mast cells w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5848e8bc7da58aa3c1e27dd2a19fa74
https://doi.org/10.1007/bf01534559
https://doi.org/10.1007/bf01534559
Publikováno v:
Inflammation. 17:723-741
The effects of topical application of arachidonic acid (AA) or phorbol ester, tetradecanoylphorbol 13-acetate (TPA), on edema response, vascular permeability, MPO, NAG, and generation of eicosanoids were studied in two murine models of cutaneous infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f92f9c916750b0f0851be2630025537
https://doi.org/10.1007/bf00920477
https://doi.org/10.1007/bf00920477
Publikováno v:
Mediators of Inflammation, Vol 2, Iss 5, Pp 357-362 (1993)
Mediators of Inflammation
Mediators of Inflammation
The present investigation characterizes calcium ionophore (A-23187) induced peritoneal eicosanoid biosynthesis in the rat. Intraperitoneal injection of A-23187 (20 mug/rat) stimulated marked biosynthesis of 6-keto-PGF(1alpha) (6-KPA), TxB(2), LTC(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874e5e0c30bbbb0135e0b978b2c22791
https://doi.org/10.1155/s0962935193000493
https://doi.org/10.1155/s0962935193000493
Autor:
Okechukwu Ukairo, Hidenori Ichijo, Gabriel Mbalaviele, Medora M. Hardy, Joseph B. Monahan, Eric A. Welsh, Alexander F. Shaffer, Chad E. Storer, Liangbiao G. Hu, Patrick M. Blanner, Fernando A. Happa, Stephen J. Mnich, Shawn P. O'Neil, Hiroyuki Eda, Dave Weiss
Publikováno v:
International immunopharmacology. 10(10)
In this report, we show that apoptosis signal-regulating kinase 1(-/-) (ASK1 KO) mice were resistant to inflammatory arthritis induced in the K/BxN serum transfer model of rheumatoid arthritis (RA). The p38 inhibitor, SD-0006 was administered to wild
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4ba34623e701bb193e08847c7c09d5
https://pubmed.ncbi.nlm.nih.gov/20609399
https://pubmed.ncbi.nlm.nih.gov/20609399
Publikováno v:
Life sciences. 53(9)
Intrapleural injection of A-23187 (10 micrograms), a calcium ionophore, elicited rapid increase in biosynthesis of prostaglandins and leukotrienes in a time-dependent manner. 6-Keto-prostaglandin-F1 alpha (6-KPA) was the principal cyclooxygenase prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a82bc78f7c1c9c43757c367f20ee9a
https://pubmed.ncbi.nlm.nih.gov/8394967
https://pubmed.ncbi.nlm.nih.gov/8394967