Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alexander F. Howie"'
Autor:
Sergio Rodriguez-Cuenca, Gary A. Churchill, Antonio Vidal-Puig, Maximilian Zeyda, Nicholas M. Morton, Annalisa Gastaldello, Jasmina Beltram, Scott P. Webster, Gregor Gorjanc, Aila Saari, Thomas M. Stulnig, Simon Horvat, Vilmundur Gudnason, Roderick N. Carter, Matthew T G Gibbins, José Manuel Fernández-Real, Jonathan R. Seckl, Steven C. Munger, Clare McFadden, Gregorio Naredo, Martin E. Barrios-Llerena, Donald R. Dunbar, Christopher J Kenyon, Zhao V. Wang, Alexander F. Howie, Lynne Ramage, José María Moreno-Navarrete, Karen L. Svenson, Brian R. Walker, Valur Emilsson, Petra Sipilä, Zoi Michailidou, Rhona Aird
Publikováno v:
Morton, N M, Beltram, J, Carter, R N, Michailidou, Z, Gorjanc, G, McFadden, C, Barrios-Llerena, M E, Rodriguez-Cuenca, S, Gibbins, M T G, Aird, R E, Moreno-Navarrete, J M, Munger, S C, Svenson, K L, Gastaldello, A, Ramage, L, Naredo, G, Zeyda, M, Wang, Z V, Howie, A F, Saari, A, Sipilä, P, Stulnig, T M, Gudnason, V, Kenyon, C J, Seckl, J R, Walker, B R, Webster, S P, Dunbar, D R, Churchill, G A, Vidal-Puig, A, Fernandez-Real, J M, Emilsson, V & Horvat, S 2016, ' Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness ', Nature Medicine, vol. 22, no. 7, pp. 771-779 . https://doi.org/10.1038/nm.4115
Nature medicine
© Nature Medicine, 2016, vol. 22, p. 771-779
Articles publicats (D-CM)
DUGiDocs – Universitat de Girona
instname
Nature medicine
© Nature Medicine, 2016, vol. 22, p. 771-779
Articles publicats (D-CM)
DUGiDocs – Universitat de Girona
instname
The discovery of genetic mechanisms for resistance to obesity and diabetes may illuminate new therapeutic strategies for the treatment of this global health challenge. We used the polygenic 'lean' mouse model, which has been selected for low adiposit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d97883a5e7915270071cddd2f0f72e6
https://hdl.handle.net/2072/372198
https://hdl.handle.net/2072/372198
Autor:
Rebecca M. Reynolds, Alexander F. Howie, Simon C. Riley, Ruth Andrew, Sarah M. Barr, Shareen Forbes, John G. Lewis, Jane E. Norman, Laura I Stirrat, Maria Bowman, Jonathan R. Seckl, Brian R. Walker, Fiona C. Denison, James R. O'Reilly, Roger Smith
Publikováno v:
Psychoneuroendocrinology. 63:135-143
Background The maternal hypothalamic-pituitary-adrenal-axis (HPAA) undergoes dramatic activation during pregnancy. Increased cortisol and corticotrophin-releasing-hormone (CRH) associate with low birthweight and preterm labor. In non-pregnant obesity
Autor:
Martin E. Barrios-Llerena, Petra Sipilä, Annalisa Gastaldello, Sergio Rodriguez-Cuenca, José Manuel Fernández-Real, Rhona Aird, Gregor Gorjanc, Jasmina Beltram, Zoi Michailidou, Thomas M. Stulnig, Gary A. Churchill, Zhao V. Wang, Nicholas M. Morton, Clare McFadden, Aila Saari, Maximilian Zeyda, Vilmundur Gudnason, Donald R. Dunbar, Simon Horvat, Christopher J. Kenyon, José María Moreno-Navarrete, Antonio Vidal-Puig, Brian R. Walker, Valur Emilsson, Jonathan R. Seckl, Steven C. Munger, Karen L. Svenson, Lynne Ramage, Roderick N. Carter, Matthew T G Gibbins, Gregorio Naredo, Alexander F. Howie, Scott P. Webster
Publikováno v:
Nature Medicine. 24:525-525
Nat. Med. 22, 771–779 (2016); published online 6 June 2016; corrected after print 7 March 2018 In the version of this article initially published, the colors of the lines were switched in the graph that shows the glucose infusion rates for wild-typ
Autor:
Catherine Méplan, Graham W. Horgan, Fergus Nicol, John C. Mathers, Geoffrey J. Beckett, Alexander F. Howie, Kristina E. Hill, Lynne K. Crosley, John E. Hesketh, John R. Arthur
Publikováno v:
The FASEB Journal. 21:3063-3074
Selenium (Se), a micronutrient essential for human health, is incorporated into at least 25 selenoproteins including selenoprotein P (SePP), which transports Se within the body. This research identified two single nucleotide polymorphisms (SNPs) in t
Autor:
Fergus Nicol, Alexander F. Howie, Geoffrey J. Beckett, S W Walker, John R. Arthur, S. M. Anema
Publikováno v:
Biochemical Journal. 342:111-117
Damage to the endothelium by reactive oxygen species favours atherogenesis. Such damage can be prevented by selenium, which is thought to exert its actions through the expression of selenoproteins. The family of glutathione peroxidases (GPXs) may hav
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 83:2052-2058
Human thyrocytes incubated with the phorbol ester, phorbol 12-myristate 13-acetate (PMA; 10−5–10−8 mol/L) and the calcium ionophore A23187 (10−5–10−8 mol/L) showed a marked increase in the expression of a 57-kDa selenoprotein identified a
Autor:
R. C. Mckenzie, Fergus Nicol, John R. Arthur, Teresa S. Rafferty, Alexander F. Howie, G J Beckett, John A. A. Hunter
Publikováno v:
Biochemical Journal. 332:231-236
The generation of reactive oxygen species has been implicated as part of the mechanism responsible for UVB-radiation-induced skin damage. In mice, evidence suggests that increased dietary selenium intake may protect skin from many of the harmful effe
Autor:
Geoffrey J. Beckett, Yongping Bao, Lawrence N. Barrera, Kun Wu, Dan Li, Wei Wang, Alexander F. Howie, Yujuan Shan
Publikováno v:
Food chemistry. 133(2)
Dietary isothiocyanates and selenium are chemopreventive agents and potent inducers of antioxidant enzymes. It has been previously shown that sulforaphane and selenium have a synergistic effect on the upregulation of thioredoxin reductase-1 (TrxR-1)
Autor:
Alexander F. Howie, Catriona Clarke, Hussam Baghdadi, J. Ian Mason, Geoffrey J. Beckett, S W Walker
Publikováno v:
Biochimica et biophysica acta. 1800(6)
Background Non-alcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance and hepatic steatosis. Non-alcoholic steatohepatitis (NASH) is a serious consequence of NAFLD where chronic tissue damage and inflammation result in f
Autor:
Bernd Hoffmann, Steven D. Morley, Mariusz P. Kowalewski, Gerhard Schuler, Alexander F. Howie, JI Mason
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 101(4-5)
3beta-Hydroxysteroid dehydrogenase (3betaHSD) is a key enzyme in the synthesis of bioactive steroid hormones. Objectives of the present study were to clone canine 3betaHSD and to investigate its expression in dog corpora lutea (CL) covering the perio